鲤竖鳞病组织病理研究     

何幽峰  刘淑范 《大连水产学院学报》1997,12(1):59-63

鲤竖鳞病的组织病理变化主要表现为溶血，水肿，变性坏死和炎症，病鱼的皮肤，鳞囊，鳍、鳃、肾、肝、脾和肠都显出不同程度的病理变化，尤其是肾，锶和皮肤更严重。  相似文献   

裸小鼠繁殖群自发性肿瘤发病情况的研究     

黄培根  沈淑静  莫梅英  李飞虹 《湛江医学院学报》1993,(Z1)

对本室六年中饲养于SPF条件下的466只NC系裸鼠繁殖群动物的自发性肿瘤发病情况进行了观察研究,其中纯合子鼠(雄nu/nu)164只,杂合子鼠(雌,un/+)302只。每只动物平均观察时间均达7个月以上,淘汰时均经详细解剖学检查,检出病变者进行病理组织学及透射电镜观察确诊。多数肿瘤病例结合裸鼠间可移植性鉴定.共检出自发性肿瘤7例,发生于纯合子裸鼠5例,杂合子鼠2例。结果表明,在相同饲养环境下,裸鼠(雄,nu/nu)的自发性肿瘤发病率(3.04％)比其同系有胸腺杂合子鼠(雌,nu/+)(0.66％)明显增高(P<0.05),且前者的平均发瘤鼠龄比后者为短,其自发瘤以恶性上皮性肿瘤为主。结果支持了免疫功能缺陷的裸鼠比其同系免疫功能正常鼠有更高的自发性肿瘤的观点。作者还提出了评价裸鼠群体自发性肿瘤发病率的方法.  相似文献   

兔出血症病毒人工感染幼兔的病理学研究     

黄吉风  徐福南 《南京农业大学学报》1997,20(2):77-81

用兔出血症病毒（ＲＨＤＶ）分别感染５，１５和２５日龄家兔，接种后７２ｈ扑杀，对其肝，脾，肺，肾，胸腺，骨髓等作组织病理学和超微结构观察，发现幼兔感染ＲＨＤＶ与成年兔病毒性出血症不同，其主要病变是血管内皮细胞，网状细胞的增生和肝，肾等脏器实质细胞的变性，ＲＨＤＶ对一月龄以内幼兔抗亦具有感染性，并对其肝，肾等造成一定程度的病理损伤，病理损伤程度随年龄的增长而加重。  相似文献   

Comparison of whole blood and plasma colloid osmotic pressure in healthy dogs     

Adesola Odunayo DVM  MS  DACVECC  Marie E. Kerl DVM  MPH  DACVIM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2011,21(3):236-241

Objective – To determine the difference between colloid osmotic pressure (COP) values determined from plasma versus those determined from whole blood. Design – Prospective observational study. Settings – University veterinary teaching hospital. Animals – Fifty‐three healthy dogs. Interventions – None. Measurements and Main Results – Whole blood and plasma COP, CBC, plasma biochemistry. In all dogs, plasma COP values were significantly lower (P=0.02) than whole blood COP, with a mean of difference of 0.5 mm Hg. The mean and median whole blood COP was 21.75 and 21.4 mm Hg, respectively, with a range of 17.9–27.1 mm Hg. The mean and median plasma COP was 21.2 and 20.9 mm Hg with a range of 16.7–28.9 mm Hg. Conclusions – While significant difference exists between plasma and whole blood COP, the individual values are within expected reference intervals for dogs (21–25 mm Hg). Using either sample appears to provide the same information in clinically healthy dog; however, it is recommended that clinicians utilize the same sample type for comparison in an individual patient.  相似文献   

Angiofibroma of the nasal cavity in 13 dogs     

Burgess KE  Green EM  Wood RD  Dubielzig RR 《Veterinary and comparative oncology》2011,9(4):304-309

This case series describes a rare entity, nasal angiofibroma, in 13 dogs that were presented to the University of Wisconsin, School of Veterinary Medicine from 1988 to 2000. All dogs in this case series presented with clinical signs and radiographic changes that were strongly suggestive of a locally invasive neoplasm. However, histopathology completed on transnostral core biopsy samples revealed benign appearing vascular proliferation with secondary lymphosuppurative inflammation was established despite cytologic criteria of malignancy present in five dogs. On the basis of the outcomes in this case series, nasal angiofibroma should be considered a differential for dogs presenting with clinical signs consistent with a malignant nasal tumour.  相似文献   

Influenza A pandemic (H1N1) 2009 virus outbreak in a cat colony in Italy     

Fiorentini L  Taddei R  Moreno A  Gelmetti D  Barbieri I  De Marco MA  Tosi G  Cordioli P  Massi P 《Zoonoses and public health》2011,58(8):573-581

  相似文献   

硒中毒奶山羊组织化学检查与病理变化研究     

李国勤  王建华 《畜牧兽医学报》1995,26(1):71-75

采用Ｄａｎｓｃｈｅｒ氏组织学技术测定了口服不同剂量亚硒酸钠中毒奶山羊的心脏、肝脏、脾脏、肺脏、肾脏和大脑硒含量与分布状态；探讨了各组织器官局部病变程度与硒分布密度之间的内在联系。结果表明，中毒羊各组织器官，尤其是发生病理变化的局部组织均蓄积不同密度的反应产物；各组织局部病变程度与硒的分布密度有关，Ｄａｎｓｃｈｅｒ组织化学技术将组织硒含量与病理变化程度联系起来，为研究动物中毒病的一个实用手段。  相似文献   

The lesional changes and pathogenesis in the kidney in african swine fever     

J. Hervás  J. C. Gómez-Villamandos  A. Méndez  L. Carrasco  M. A. Sierra 《Veterinary research communications》1996,20(3):285-299

African swine fever is a viral haemorrhagic disease of pigs which has been used as a model for the study of viral haemorrhagic diseases in man. The acute course of the disease is characterized by acute proliferative glomerulonephritis, with viral replication in mesangial cells and occasional focal necrosis of the renal tubular system; hyperplasia of the collecting ducts is associated with evident virus replication. Haemorrhages have been attributed to endothelial dysfunction, aggravated by virus replication in endothelial cells in the final stages of the disease. The renal interstitium displays intense oedema and an infiltrate largely composed of macrophages. Virus replication has also been observed in fibroblasts and in the smooth0muscle cells of arterioles and venules.In subacute-chronic forms of the disease, various types of glomerulonephritis are observed, ranging from mesangial proliferative glomerulonephritis to focal and segmental hyalinosis associated with immune-mediated phenomena. No striking changes are reported in the renal tubular system. Interstitial haemorrhages are associated with diapedesis due to immunologically mediated events. The interstitium has also been found to contain a lymphohistiocytic infiltrate with abundant plasma cells. No evidence has been reported of viral replication in any cell population.Abbreviations ASF African swine fever - ASFV African swine fever virus - C complement component - DNA deoxyribonucleic acid - HAD₅₀ 50% haemoadsorbing doses - Ig immunoglobulin - MPS mononuclear phagocytic system - PAS periodic acid-Schiff reagent  相似文献   

Induced Acute Ruminai Acidosis in Goats Treated with Yeast (Saccharomyces cerevisiae) and Bicarbonate     

V. Aslan  S. M. Thamsborg  R. J. Jrgensen  A. Basse 《Acta veterinaria Scandinavica》1995,36(1):65

Ruminai acidosis was induced in twenty-one 10-month-old West African Dwarf Goats by feeding a suspension of 80 g wheat flour per kg body-weight (day 0) through a stomach tube. Ruminai and systemic acidosis was diagnosed on day 1 in all goats. Clinical signs included loss of rumination and appetite, trembling, and watery diarrhoea. The detection of acidic faeces during the first 24h was considered of diagnostic importance. Subgroups were treated orally on days 1,2, and 3 either with 1 g of sodium bicarbonate per kg bodyweight, with 1 g of baking yeast per kg, or with a combination of these treatments at 0.5 g of each per kg. A fourth group served as untreated controls.Peroral bicarbonate neutralization was highly effective in the treatment of rumen acidosis, whereas the use of yeast was found ineffective. The combined treatment had a moderate effect probably due to the bicarbonate.Three fatal cases (60%) occurred in the untreated group compared with none in the bicarbonate group, and 2 in each of the remaining groups. This corresponded to 33% of the yeast treated group and 40% of the combined treated group. Details were given on post mortem examinations performed on all survivors on day 11. Lesions included subacute rumenitis and abomasal ulcers. No lesions were found in 3 of the bicarbonate treated goats and in 2 of the animals receiving combined treatment.  相似文献   

SNOMED representation of explanatory knowledge in veterinary clinical pathology     

Zimmerman KL  Wilcke JR  Robertson JL  Feldman BF  Kaur T  Rees LR  Spackman KA 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2005,34(1):7-16

BACKGROUND: The Systematized Nomenclature of Medicine (SNOMED) is an established standard nomenclature for the expression of human and veterinary medical concepts. Nomenclature standards ease sharing of medical information, create common points of understanding, and improve data aggregation and analysis. OBJECTIVES: The objective of this study was to determine whether SNOMED adequately represented concepts relevant to veterinary clinical pathology. METHODS: Concepts were isolated from 3 different types of clinical pathology documents: 1) a textbook (Textbook), 2) the Results sections of industry pathology reports (Findings), and Discussion sections from industry pathology reports (Discussion). Concepts were matched (mapped) by 2 reviewers to semantically-equivalent SNOMED concepts. A quality score of 3 (good match), 2 (problem match), or 1 (no match) was recorded along with the SNOMED hierarchical location of each mapped concept. Results were analyzed using Cohen's Kappa statistic to assess reviewer agreement and chi-square tests to evaluate association between document type and quality score. RESULTS: The percentage of good matches was 48.3% for the Textbook, 45.4% for Findings, and 47.5% for Discussion documents, with no significant difference among documents. Of remaining concepts, 40% were partially expressed by SNOMED and 14% did not match. Mean reviewer agreement on quality score assignments was 76.8%. CONCLUSIONS: Although SNOMED representation of veterinary clinical pathology content was limited, missing and problem concepts were confined to a relatively small area of terminology. This limitation should be addressed in revisions of SNOMED to optimize SNOMED for veterinary clinical pathology applications.  相似文献