大叶斑鸠菊药效学初探     

林洁  杨敏  刘娟  崔大棚  吕雪  杜林林 《中兽医医药杂志》2011,13(6):16-19

目的：初探大叶斑鸠菊的药效。方法：将大叶斑鸠菊制成浓度为1 g生药/mL的提取液,通过抑菌试验、利尿试验及对鸡肾肿的治疗试验,考察其药效。结果：大叶斑鸠菊提取液对大肠杆菌、沙门氏菌、巴氏杆菌有一定抑制作用,最小抑菌浓度均为0.25 g/mL,对金黄色葡萄球菌无抑制效果;有一定利尿作用;饲喂0.4、0.5、0.6 g/mL不同剂量大叶斑鸠菊提取液,2次/d,鸡肾肿明显减轻,鸡的存活率提高,分别为42.86%、71.43%和85.71%。结论：大叶斑鸠菊具有一定抑菌作用、利尿作用,对鸡肾肿有较好的治疗效果。  相似文献   

Paraneoplastic leukocytosis in a dog with a renal carcinoma     

Petterino C  Luzio E  Baracchini L  Ferrari A  Ratto A 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2011,40(1):89-94

A 7-year-old male German Shepherd dog in poor body condition had a 3-month history of intermittent hematuria. Nonregenerative anemia, mild leukocytosis, marked hypoalbuminemia, and hematuria were observed. Subsequently, marked neutrophilia and moderate monocytosis were noted; anemia, hypoalbuminemia, and hematuria persisted; and the dog developed disseminated intravascular coagulation. Ultrasonographic examination of the abdomen revealed the presence of an enlarged and irregularly shaped right kidney with a large area of cavitation, and a nephrectomy was performed 30 days after initial examination. Cytologic examination of fine-needle aspirates and imprints of the right kidney revealed a neoplastic cell population suggestive of renal carcinoma. The histopathologic diagnosis was chromophobic cystic-papillary renal carcinoma. The tumor cells expressed granulocytic/macrophage-colony-stimulating factor (GM-CSF), detected by immunohistochemical staining, and elaboration of GM-CSF by the tumor may have mediated the leukocytosis in this dog. Following excision of the tumor, neutrophil and monocyte counts were only mildly increased. The dog died 135 days after initial presentation, and a necropsy was not permitted. Paraneoplastic neutrophilic leukocytosis is an uncommon finding and may be caused by elaboration of CSF by neoplastic cells.  相似文献   

高钙日粮对青年蛋鸡肾脏中XOD基因mRNA表达的影响     

郭小权  曹华斌  黄克和  胡国良  雷鹏  田山  国鑫 《中国兽医学报》2011,31(11)

选择35日龄伊沙蛋鸡100羽,随机均分为对照组（含钙1.00％）和高钙组（含钙3．78％）。于试验30d每组选取体质量相近的试验蛋鸡5羽,取肾脏样品,应用半定量逆转录聚合酶链式反应技术测定XODmRNA在肾脏中的表达水平。结果显示：高钙组肾脏中XODmRNA对β-actinmRNA的相对丰度显著高于对照组。说明高钙日粮可促进鸡肾脏的XODmRNA的表达。  相似文献   

The intra‐ and intertester repeatability of radiographic elbow incongruity grading is high in chondrodystrophic dog breeds     

Hanna S. M. Pulkkinen  Vilma L. J. Reunanen  Heli K. Hyytiinen  Jouni J. T. Junnila  Outi M. Laitinen‐Vapaavuori  Anu K. Lappalainen 《Veterinary radiology & ultrasound》2020,61(3):329-335

Elbow incongruity is a form of elbow dysplasia that causes osteoarthritis, pain, and lameness, and it is common in chondrodystrophic dog breeds. The objective of this retrospective secondary analysis study was to evaluate the intra‐ and interobserver repeatability of a novel radiographic incongruity grading system for assessing elbow incongruity in three chondrodystrophic dog breeds—the dachshund, Skye Terrier, and Glen of Imaal Terrier. We conducted an observer agreement study that included 220 mediolateral antebrachial radiographs from 110 dogs with the elbow in 90° flexion. The radiographs were independently assessed by three observers at three time points, using a four‐stepped grading scale. The proportion of agreement and Kappa coefficient were calculated. Both the intra‐ and interobserver proportions of agreement were substantial when three grades were required to be identical (.705‐.777 and .609, respectively), and almost perfect for two identical grades (.991‐1.000 and .991, respectively). Some differences in repeatability between breeds were noted; specifically, the intraobserver repeatability was higher in the dachshund, and the interobserver repeatability was lower in the Glen of Imaal Terrier. Our study showed that the radiographic imaging protocol and incongruity grading system have high repeatability when assessing elbow incongruity in chondrodystrophic dog breeds.  相似文献   

Anaplastic nephroblastoma with peritoneal metastasis in an adult female Sprague Dawley rat     

Lisa Quinn  James G Fox  Joanna Joy  Sureshkumar Muthupalani  Sebastian E Carrasco 《Journal of toxicologic pathology》2020,33(4):297

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高铜对大鼠肾细胞炎性因子和细胞增殖的影响   总被引：1，自引：1，他引：0  

于晴晴  钟高龙  万方  宁芷君  伍少峰  蒋璇璇  唐兆新  何颖  胡莲美 《畜牧兽医学报》2020,51(11):2849-2857

旨在探讨铜中毒对大鼠肾组织炎性因子的表达和细胞增殖功能的影响。本研究选用32只20日龄健康大鼠随机分为4组,每组8只,其中,对照组日粮的铜（Cu）浓度为15 mg·kg^-1;高铜Ⅰ组日粮Cu浓度为30 mg·kg^-1;高铜Ⅱ组日粮Cu浓度为60 mg·kg^-1;高铜Ⅲ组日粮Cu浓度为120 mg· kg^-1。连续饲喂6个月,检测肾组织Ki-67、PCNA、IL-1β、IL-2、IL-6、IL-18、NF-κB、TNF-α的mRNA及其蛋白的表达。随着日粮中铜含量增高,肾组织中Ki-67、PCNA mRNA及其蛋白表达量显著降低（P<0.05）。炎性因子IL-1β、IL-2、IL-6、IL-18、NF-κB、TNF-α mRNA的表达水平显著升高（P<0.05）,IL-1β蛋白的表达水平呈剂量依赖性上升,IL-6和IL-18蛋白表达水平先上升,后下降。结果表明,日粮铜含量高于30 mg·kg^-1时,将不同程度地抑制大鼠肾组织的细胞增殖,促进炎性因子的表达,造成炎性损伤。  相似文献   

Relationship between serum iohexol clearance,serum SDMA concentration,and serum creatinine concentration in non-azotemic dogs     

Myles McKenna  Ludovic Pelligand  Jonathan Elliott  Daniel Cotter  Rosanne Jepson 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2020,34(1):186-194

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绿茶抗大鼠肾间质纤维化作用的实验研究     

姜岳  邱模炎  孙慧  李葆青 《茶叶科学》2008,28(5)

采用"单肾切除加腺嘌呤灌胃法"建立大鼠慢性肾衰竭模型。治疗组予绿茶液灌胃治疗,对照组予尿毒清溶液灌胃治疗,连续治疗28天。取大鼠肾脏石蜡切片分别进行HE染色、PASM染色、Masson染色、Sirius Red染色、Mallory染色,光镜下观察大鼠肾组织5种染色的病理形态学改变,PASM染色、Masson染色、Sirius Red染色随机选择进行肾脏组织病理学图像分析。绿茶组在肾间质纤维化面积、肾小球系膜积分光密度值、肾间质中I、Ⅲ型胶原分布面积等方面的作用与模型组对比,P<0.05。说明绿茶能够减轻腺嘌呤对大鼠肾间质的病理损害,绿茶有抗肾间质纤维化的作用,并且能抑制I、Ⅲ型胶原纤维的增生,这可能是绿茶防治肾间质纤维化、延缓慢性肾衰竭发展进程的机制之一。  相似文献   

双峰驼肾动脉分布     

陈秋生  刘仪 《中国兽医学报》2000,20(6):565-568

应用大体解剖学和血管铸型方法,研究了12峰双峰驼肾动脉的分支分布。结果显示,肾脏的肾动脉在进入肾门之前均分成一背干和一腹干,在肾窦内,背干分为一前支,再由前、后支分别发出背部贤脏的各肾段动脉。腹干不分前、后支,而由主干直接发出腹部肾脏的各肾段动脉。不仅各肾段动脉之间未见吻合,背干及其分支与腹干及其分支之间也无吻合。左肾肾段动脉共13条,右肾肾段动脉12条。表明,双峰驼不仅左、右肾的肾动脉与肾段动脉不尽相同,各肾的背部和腹部的动脉供应也存在差异。肾动脉的背干和腹干是相对独立的。  相似文献   

USE OF ^99mTc-MERCAPTOACETYLTRIGLYCINE TO EVALUATE RENAL FUNCTION IN HORSES     

Philip R.  Woods  DVM  PhD  Wm. Tod  Drost  DVM  Cyril R.  Clarke  BVSc  PhD  Carolyn J.  Rodebush  RT 《Veterinary radiology & ultrasound》2000,41(1):85-88

Ten healthy horses were injected intravenously with 99mTc-MAG3 and the disappearance of radioactivity from the blood was measured. The total body clearance (Cl(B)) and elimination half-life (t1/2(beta)) were 7.9 +/- 1.5 ml/kg/minute and 32.8 +/- 4.1 minutes, respectively. The disappearance of 99mTc-MAG3 from the blood of 2 horses with compromised renal function was also measured. The data suggest that 99mTc-MAG3 is a useful and clinically applicable radiopharmaceutical for measurement of effective renal blood flow in the horse.  相似文献