In situ detection and significance of hTERT in giant cell tumor of bone     

SHEN Hui-yong  TANG Yong  LIU Shang-li  LI Hai-gang 《园艺学报》2003,19(9):1224-1226

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A REVIEW OF NONCONVENTIONAL ULTRASOUND TECHNIQUES AND CONTRAST-ENHANCED ULTRASONOGRAPHY OF NONCARDIAC CANINE DISORDERS     

Viktor  Szatmári  DVM  Zoltán  Harkaanyi  MD  PhD  Károly  Vöaröas  DVM  PhD 《Veterinary radiology & ultrasound》2003,44(4):380-391

Modern ultrasound contrast media are gas-containing stabilized microbubbles that remain intact in the circulating blood for several minutes after intravenous injection and increase the intensity of the backscattered ultrasound. When the microbubbles disappear from the blood, they can be detected in the parenchyma of the liver and the spleen for about 30 more minutes (late liver- and spleen-specific phase). The insonated microbubbles produce second harmonic ultrasound frequencies, whose detection requires nonconventional ultrasound modalities such as pulsed inversion imaging. Nonconventional ultrasound techniques can also be used without microbubbles because second harmonics can be generated by ultrasound in tissues as well. The physical principles and advantages of nonconventional ultrasound techniques are described. The circulating microbubbles can be used not only to enhance weak Doppler signals, but also to perform dynamic contrast studies. Contrast-enhanced dynamic ultrasound studies--similar to contrast-enhanced CT and MRI examinations--have been used in humans to characterize lesions noninvasively (i.e., without biopsies) found during conventional ultrasound examinations. To map the distribution of contrast medium in a nodule or in an organ, specific scanning techniques such as stimulated acoustic emission have been developed. Stimulated acoustic emission occurs when high acoustic pressure ultrasonic waves disrupt the stationary or slowly moving microbubbles. This results in the release of a large amount of harmonic ultrasound frequencies. When the stimulated acoustic emission technique is used for dynamic studies, scanning must be interrupted several times to allow the microvasculature of the lesion to refill with microbubbles (interval delay imaging). The contrast patterns of malignant and benign hepatic nodules in humans have been the most intensively studied. Another type of dynamic study in humans measures the transit time of the contrast medium; that is, how fast the peripherally injected microbubbles reach the hepatic veins. Hepatic cirrhosis can be differentiated from other diffuse parenchymal liver diseases by a shorter transit time. Introducing nonconventional ultrasound techniques and ultrasound contrast media in veterinary diagnostic imaging may have potential value; however, intensive research should be carried out before ultrasound contrast agents can routinely be used in clinical practice.  相似文献   

Progress of ELMO family on malignant tumor invasion and metastasis     

GUO Cheng-ming  PENG Hui-yun  LUO Wen  YU Qiong-fang  GAO Dian 《园艺学报》2015,31(12):2296-2300

It is one of the main characters of malignant tumors that malignant tumor cells invade surrounding tissues and metastasize to distant tissues. Multiple factors are involved in this complicated dynamic process. Metastasis is the major factor influencing recurrence and prognosis. Therefore, it is important to explore the mechanism of invasion and metastasis for reducing recurrence rate and mortality of malignant tumors. Engulfment and cell mobility (ELMO) family is one kind of conserved protein in evolutional process. It includes 3 members, ELMO1, ELMO2 and ELMO3. The members of ELMO family play an important role in cell phagocytosis and cell migration, and they also have close correlation with malignant tumor cell invasion and metastasis. In this paper, we review the progress of the relationship between ELMO family and malignant tumor invasion and metastasis.  相似文献   

Research Progress of the Cure Effect of Eelectrochemotherapy on Tumor     

XIONG Lan  SUN Cai xin  LI Da qiang  LIAO Rui jin  HU Li na 《保鲜与加工》2002,(5):70-72

Electrochemotherapy is a new therapy on curing tumor, and it consists of two therapies, which are direct current electrochemotherapy and electric pulse aided antitumor medicine electrochemotherapy. Its widely application prospect is being taken on. Researchers home and overseas study deeply in the wide field of its cure mechanism, ways and means, animal tests and clinical application. Medical studies have shown that electrochemotherapy is an easily operated therapy with excellent curative effect and security. On the basis of these studies, a new therapy is put forward, that is, energy-controllable steep pulse therapy, electric pulse' killing effect on cell membrane is called as irreversible breakdown, and the first-stage study results of this new therapy are introduced.  相似文献   

Reserarch advance on mechanism of arsenic trioxide on tumor     

GUO Li-xi  WANG Yuan-liang  XIN Juan nistry of Education  College of Bioengineering  Chongqing University  Chongqing  Chin 《保鲜与加工》2004,(8):47-51

The article demonstrates the relative concepts of apoptosis and summarizes the effect of arsenic trioxide to the carcinoma, its possible principle included. Recent development of the reports about arsenic trioxide-induced apoptosis is referred and reviewed. Apoptosis is a natural mechanism and a common physiological death of cell, and its abnormity has great effect on cancer. Arsenic trioxide can induce apoptosis in APL cell and other cancer cells, and has been used in treating the patient with other kinds of malignant cancers. The mechanisms of arsenic trioxide-induced apoptosis are gradually becoming a hotspot, but still not lucid. With intensive study of arsenic trioxide, it can be a useful ways in treating cancer patients in the future.  相似文献   

羟基喜树碱(HCPT)对乳腺癌细胞中TIMP-3表达及细胞侵袭能力的影响     

周萍  汪洋  付利娟 《西南大学学报(自然科学版)》2011,33(4)

目的:探索羟基喜树碱对乳腺癌细胞MCF-7细胞信号转导相关基因金属蛋白酶组织抑制剂-3(TIMP-3)表达的影响,寻找羟基喜树碱(HCPT)在乳腺癌治疗中的潜在新靶点.方法:分别采用Q-PCR,Western-blot和免疫细胞化学等方法验证不同剂量组HCPT诱导MCF-7细胞的TIMP-3表达特征.结果:不同质量浓度的HCPT均可在mRNA水平和蛋白水平诱导MCF-7细胞的TIMP-3表达上调,且具有统计学意义,与前期的基因芯片研究结果相符合;实验同时观察了HCPT对细胞侵袭迁移能力的影响,结果亦显示HCPT可在TIMP-3表达上调的同时抑制细胞侵袭迁移能力.结论:HCPT可诱导乳腺癌细胞的TIMP-3上调表达,抑制细胞侵袭能力.  相似文献   

经鼻小柱,鼻中隔,蝶窦入路行脑垂体瘤切除术     

赵革灵  罗学忠 《湛江医学院学报》1996,14(3):214-215

经鼻小柱、鼻中隔、蝶窦入路行鞍内肿瘤切除术６例的结果表明：经鼻小柱、鼻中隔、蝶窦入路不但可避免唇下入路的某些并发症，且手术疗效一致。指出磁共振成像在垂体微腺瘤的定位诊断与指导肿瘤切除中具有重要价值，倡导神经外科与鼻喉科密切合作。  相似文献   

樱桃砧木根癌病敏感性评价方法   总被引：5，自引：0，他引：5  

赵玉辉  周宇  张开春  李作轩  王力华 《沈阳农业大学学报》2005,36(5):609-611

建立了樱桃砧木对农杆菌敏感性的评价方法,在5种樱桃砧木,对樱桃(Prunus.pseudocerasus)、CAB(P.cerasus)、Gisela5、Gisela6(P.cerasus×P.canescens)、colt(P.avium×P.pseudocerasus)的组培苗茎上接种野生型农杆菌(C58),40d后调查结瘤百分率和瘤重,基于结瘤百分率和病情指数评价了供试材料的敏感性,结果表明:该方法能反映不同砧木的抗性水平,可作为樱桃砧木根癌病敏感性评价、筛选抗性种质的一种有效的方法。  相似文献   

保留畜禽脑脊髓附韧带骨架标本制作技术   总被引：1，自引：0，他引：1  

张书松  张玉龙 《河南农业大学学报》1995,29(1):88-90

用“保留畜禽脑脊髓附韧带”技术制作的整体骨架标本保留脑脊髓和关节韧带，不需脱脂、漂白，不必用铁丝穿制，较传统的沤制，煮制方法省时省力，节省资金，即能显著畜禽生态姿势，又能体现骨，关节，韧带标本的完整性。用该技术制作的畜禽整体骨架标本１５ａ未见虫蛀，霉变，散架，变形，无损无缺，色泽逼真，是解剖学骨骼标本制作的１种新方法。  相似文献   

鸡卵巢传入神经元在脊神经节内的节段性分布     

董常生  郭和以  刘为民  马仲华 《山西农业大学学报(自然科学版)》1991,(2)

将CB—HRP(霍乱毒素B亚单位结合态的辣根过氧化物酶)溶液注入母鸡卵巢内,逆行追踪研究了分布于卵巢的感觉神经元的定位及其规律性。结果表明:①分布于鸡卵巢,经交感途径传入的感觉神经元胞体位于T_1—L_3节段的脊神经节内,峰值在T_6节段。说明鸡卵巢经交感途径传入的感觉神经元的分布具有相对的集中性和弥散性。②脊神经节内的标记细胞以小细胞居多,推测鸡卵巢内可能含感受损伤性刺激的纤维占绝对优势。  相似文献