Caudal epidural co-administration of methadone and morphine in horses: An evaluation of analgesic properties and effects on locomotor function,mentation and physical examination parameters     

L. N. Rønnow Kjærulff  N. J. Dorch Lauritsen  C. Thorn Ekstrøm  S. Østergaard  E. Olsen  S. Hyldahl Laursen  C. Lindegaard 《Equine Veterinary Education》2021,33(7):360-367

Caudal epidural analgesia is a well-established therapeutic modality for pain alleviation in horses. Additionally, epidural analgesia could potentially be a complementary diagnostic tool for confirmation of pain-related conditions in horses presenting with nonspecific signs of poor performance or rideability issues. To use the epidural as a diagnostic tool, the administered medications should provide efficient analgesia without accompanying adverse effects. Therefore, the objectives of the current study were to evaluate the analgesic properties and effects on locomotor function, mentation and physical examination parameters of caudal epidural co-administration of methadone and morphine in horses. Five mares received a caudal epidural injection of 0.1 mg/kg bwt methadone and 0.1 mg/kg bwt morphine diluted to a total volume of 4.4 mL/100 kg. Before and several times thereafter, horses were subjected to mechanical nociceptive threshold evaluation, physical examination, assessment of mentation and locomotor function examination. Horses were assigned ataxia scores (0–4) by a group of inexperienced raters (three senior-year veterinary students) and a group of experienced raters (two board-certified internal medicine specialists) that assessed the locomotor examinations either live or video-based. The epidural co-administration of methadone and morphine resulted in clinically relevant and statistically significant increases of horses’ tolerance to mechanical noxious stimuli at the coccygeal, perineal, sacral, lumbar and thoracic regions. Analgesia was evident after 4.4 h and lasted at least 5 h. Regional differences in the onset of analgesia reflected a cranial spread of the analgesic solution. No horses showed signs of gait disturbances; the overall median ataxia score was 0 at all times; and the average difference in scores between two randomly selected raters for a random horse at a random time point was 0.377 indicating high inter-rater agreement. There were no adverse changes of mentation and physical examination parameters. Observed side effects included signs of decreased frequency of defaecation, generalised sweating, and pruritus.  相似文献   

Relationship between calving difficulty and fertility traits in first‐parity Iranian Holsteins under standard and recursive models          下载免费PDF全文

M.S. Mokhtari  M. Moradi Shahrbabak  A. Nejati Javaremi  G.J.M. Rosa 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2016,133(6):513-522

The main objective of this study was to estimate the genetic and phenotypic relationships between calving difficulty (CD) and fertility traits, including success at first service (SF), number of inseminations to conception (INS), interval from calving to first service (CTFS), interval between first and last service (IFL) and days open (DO), in first‐parity Iranian Holsteins under standard (SMMs) and recursive (RMMs) mixed models. The data analysed in this paper included 29 950 records on CD and fertility traits, collected in the time period from 1995 to 2014 by the Animal Breeding and Improvement Center of Iran. Under all observed SMMs and RMMs, five bivariate sire‐maternal grandsire models (ten bivariate analyses in total) were used for the analyses. Recursive models were applied with a view to consider that CD influences the fertility traits in the subsequent reproductive cycle and the genetic determination of CD and fertility traits by fitting CD as covariate for any of the fertility traits studied. The existence of such cause‐and‐effect is considered in RMMs but not in SMMs. Our results implied a statistically non‐zero magnitude of the causal relationships between CD and all the fertility traits studied, with the former influencing the latter. The causal effects of CD on SF (on the observed scale, %), INS, CTFS, IFL and DO were ?2.23%, 0.10 services, 1.93 days, 3.76 days and 5.61 days, respectively. Direct genetic correlations between CD and the fertility traits under both models were not statistically different from zero (95% HPD interval included zero), except for the correlation between CD and CTFS, which were 0.197 and 0.134 under SMM and RMM, respectively, indicating that genes associated with difficult births also increase intervals between calving and the first insemination afterwards. Comparison of both models by the deviance information criterion (DIC) demonstrated the plausibility of RMMs over SMMs.  相似文献   

Sublethal effects of nine insecticides on Drosophila suzukii and its major pupal parasitoid Trichopria drosophilae     

Fabrizio Lisi  Ramzi Mansour  Carmelo Cavallaro  Tuğcan Alınç  Emanuele Porcu  Michele Ricupero  Lucia Zappalà  Nicolas Desneux  Antonio Biondi 《Pest management science》2023,79(12):5003-5014

Background

Although the pupal parasitoid Trichopria drosophilae is used in conservative and augmentative biocontrol of Drosophila suzukii infestations, current pest management strategies mostly rely on multiple insecticide applications. In this context, the aim of the study was to investigate the baseline toxicity of nine insecticides on D. suzukii larvae and their multiple sublethal effects (LC₁₀) on immature stages of the pest feeding on contaminated diet and T. drosophilae developing within the intoxicated host.

Results

Chlorpyriphos and azadirachtin showed the lowest and the highest LC₁₀, the values of which were 9.78 × 10¹³ and 1.46 × 10³ times lower than their recommended label field rate, respectively. Among tested insecticides, imidacloprid, malathion and dimethoate were the only treatments that did not affect the juvenile development time of D. suzukii, while spinosad and the organophosphates chlorpyriphos and dimethoate did not influence fly pupal size. No sublethal effects were recorded on T. drosophilae degree of infestation (DI) and juvenile development time. On the contrary, cyazypyr and dimethoate negatively affected the success of parasitism (SP) and the number of progeny of the pupal parasitoid, in association with malathion for the first parameter and spinosad for the fertility. Compared to the untreated control, more female progeny emerged following azadirachtin exposure, while dimethoate caused the opposite effect. Imidacloprid, lambda-cyhalothrin and spinetoram decreased hind tibia length of emerged parasitoids.

Conclusion

This study provides new insights on the (eco)toxicological profile of nine insecticides and new information needed to support the deployment of T. drosophilae in the field within the sustainable management techniques against D. suzukii. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.  相似文献   

对Bt毒蛋白不同抗性水平棉铃虫品系的生物学研究   总被引：1，自引：0，他引：1  

崔学芬  夏敬源 《棉花学报》2003,15(3):163-165

用对Bt毒蛋白(Cry1Ac)具有一定抗性水平的安阳品系和相对敏感的新疆品系棉铃虫进行Bt毒蛋白(Cry1Ac)的室内毒力测定结果表明,两品系的LC50值分别为8.7645g·L 1和0.2547g·L 1,前者是后者的34.4倍。用转Bt基因抗虫棉中棉所29和常规棉花品种中棉所35蕾期的倒3叶饲养安阳品系和新疆品系棉铃虫的初孵幼虫(孵化后24h),结果表明:两个棉铃虫品系在取食抗虫棉后的累计校正死亡率在1～2d内差异不明显;新疆品系棉铃虫在转Bt基因抗虫棉上发育的最高龄期为4龄,其比率为6.7%;而安阳品系部分棉铃虫能够在转Bt基因抗虫棉上完成生长发育,其4龄幼虫的比率为45.5%,5、6龄幼虫的比率分别为12.6%和3.8%,有1.6%的幼虫能够正常化蛹;用常规棉棉叶饲养的安阳品系和新疆品系棉铃虫各龄幼虫的发育历期差异不显著,而用转Bt基因抗虫棉棉叶饲养的安阳品系棉铃虫幼虫的发育历期与新疆品系虽然差异不显著,但前者的发育历期均短于后者。  相似文献   

The Biological Effects of Low Frequency Electromagnetic Fields on Cells     

LIU Xin~  ZHU Jian~  ZHONG Ji-kang~ 《保鲜与加工》2004,(1):112-115

The biological effects of ELFMES including proliferation and apoptosis of cells as well as the damage of DNA are initially evaluated with the treatment of plant cells and human pulmonary fibroblasts in low frequency magnetic fields with certain intensity and different time intervals in vitro. Cell culture, counting in vitro, fluorescent dyeing analysis and single cell gel electrophoresis are adopted. The results demonstrate that the electromagnetic field with the intensity of 3mT can affect the proliferation and apoptosis of cells significantly.  相似文献   

Optimum Planting System for Energy Saving and Healthy Demanded     

BAI Xue lian 《保鲜与加工》2002,(8):77

It is proved that planting is effective to improve environment both indoor and outdoor resulted from the functions of plants to clean air and save energy. So the contradiction between saving energy and comfort,healthy demanded by people can be solved by planting. The planting have being emphasized and expanded during recent years,but in the planting plan,just the function of beautifying the environment is concerned and the function of ecological and saving energy are neglected. The analysis on the ooptimum system of planting is to make the planting system as an organic composition in the effectiveness structure and space layout of the city. Based on the study on equivalent relation of different effects on environment, the optimum system of planting structure will be determined in order to achieve the integrated effects of planting on environment.  相似文献   

高产优质商品玉米生产模式：—三种遗传效应集成利用（TEU）   总被引：3，自引：0，他引：3  

段民孝  宋同明等 《种子》2001,(2):3-6

通过大量详实资料，对玉米杂种优势、雄性不育，油分基因花粉直感等3种遗传效应的研究现状作了详细概述，根据相关的遗传理论与实践，提出了将三种遗传效应进行技术集成的可能性，从而形成一种高产高油玉米生产模式，有可能是未来玉米生产的发展方向。  相似文献   

人民公社阶段的农地产权制度变迁及其绩效     

吴玲  王晓为  梁学庆 《中国农学通报》2006,22(11):480-480

研究人民公社阶段的农地产权制度变迁与绩效，是为了分析人民公社制度得以长期维持的原因，以期为新时期农村经济体制改革提供启示与借鉴。文章在相关文献资料的基础上，采用实证描述与规范研究分析方法，探讨人民公社阶段的农地产权制度的演进、特征、变迁的原因、内在缺陷以及制度绩效，研究表明，人民公社阶段农地产权严重残缺、缺少激励机制、组织管理费用高昂，这种制度安排实际上一开始就处于非均衡状态，依靠国家主流的意识形态和超经济强制来维持，致使人民公社阶段农地产权制度效率低下。改革开放后，中国社会政治和意识形态方面的约束放松，获取存在于人民公社制度之外的巨大外部利润，推动了农地产权制度创新。  相似文献   

Agricultural practice changes with cultivating genetically modified herbicide-tolerant oilseed rape     

F. Graef  U. Stachow  A. Werner  G. Schütte 《Agricultural Systems》2007

To facilitate weed suppression, oilseed rape or canola (Brassica napus) has been genetically modified (GM) over the last two decades to incorporate herbicide tolerance (HT). The introduction of oilseed rape in commercial agriculture raises concerns about potential adverse agronomic and environmental effects linked to both the genetic modification and altered agricultural practice. How will this new crop modify the existing cropping practice? What are the potential agro-environmental implications of its introduction? This paper analyses and schematises recorded and conceivable agricultural practice changes with GMHT oilseed rape introduction and its likely agro-environmental effects. It develops a conceptual systematics of influencing factors, subsequent practice changes and likely agro-environmental effects. The results can be used to design the mandatory monitoring of adverse GM crop effects.  相似文献   

节水灌溉综合效应评价研究进展   总被引：7，自引：0，他引：7  

吴景社  康绍忠  王景雷  黄修桥 《灌溉排水学报》2003,22(5):42-46

综述了20世纪80年代以来节水灌溉综合效应评价领域的研究进展。分析了目前存在的主要问题:缺乏较为完善的基础数据平台、评价方法亟待实用化、亟需建立符合不同层次评价需求的指标体系、规划缺乏科学性,与生产实践脱节等。提出应加强节水灌溉基础理论与节水潜力分析、完善现有节水灌溉技术标准、重视节水灌溉项目综合效应评价方法及评价体系研究和已建节水示范区综合效应的评价等。  相似文献