Efficacy of Enrofloxacin in the Treatment of Canine Bacterial Pyoderma   总被引：1，自引：0，他引：1  

MANON PARADIS  SUZIE LEMAY  DANNY W. SCOTT  WILLIAM H. MILLER  JOCELYN WELLINGTON  RADA PANICH 《Veterinary dermatology》1990,1(3):123-127

Abstract— Bacterial pyoderma was diagnosed in 30 dogs which were subsequently treated with enrofloxacin administered orally at 2.5 mg.kg^-1 of body weight every 12 h, for 2 to 14 weeks. Dogs were re-examined at the conclusion of antibiotic treatment and 28 (93.3 per cent) were found to have an excellent response. Relapses were seen in 25 per cent of these dogs after follow up periods of 1 to 4 months. Minor side effects were seen in only 1 dog. On the basis of this study, enrofloxacin is an excellent antibiotic for the treatment of canine bacterial pyoderma but must be administered well beyond the manufacturer's maximum recommendation for duration of therapy. Résumé— Une pyodermite bactérienne a été diagnostiquée chez 30 chiens qui furent traités avec de l'enrofloxacine administrée par voie orale à la dose de 2.5 mg/Kg toutes les 12 heures, pour une durée allant de 2.5 à 14 semaines. Les chiens furent réexaminés à la fin de l'antibiothérapie et 28 d'entre eux (93.3%) présentaient une excellente réponse au traitement. Des rechutes furent observées chez 25% des chiens lors de suivis portant sur des périodes de 1 à 4 mois. Des effets secondaires mineurs furent observés chez l'un des chiens. Cette étude montre que l'enrofloxacine est un excellent antibiotique pour le traitement des pyodermites canines mais, qu'il doit être administré pendant des délais beaucoup plus longs que ceux qui sont indiqués par le fabricant. Zusammenfassung— 30 Hunde mit bakteríellen Pyodermien wurden zweieinhalb bis vierzehn Wochen lang oral mit Enrofloxacin behandelt (2 täglich 2.5 mg/kg KGW). Nach Abschluß der Behandlung wurden die Tiere erneut untersucht. Bei 28 Patienten (93.3%) wurden hervorragende Ergebnisse erzielt. Bei 25% kam as nach 1 bis 4 Monaten zu Rezidiven. Geringe Nebenwirkungen wurden nur in einem Fall beobachtet. Die vorliegende Untersuchung zeigt, daß Enrofloxacin ein hervorragendes Antibiotikum für die Behandlung von Pyodermien ist, aber wesentlich länger als vom Hersteller angegeben verabreicht werden muß. Resumen Treinta perros, a los cuales se había diagnosticado una epiderma bacteriana, fueron tratado con Enrofloxacina via oral a una dosis de 2,5 mg/kg de peso corporal cada 12 horas durante un período de tiempo que oscíló entre las 2,5 semanas y las 14 semanas. Los perros se examinaron clínicamente de nuevo cuando acabó el tratamiento antibiótico y se observó en 28 (93,3%) una respuesta excelente. En un 25% de estos perros se observaron recidivas en un período comprendido entre uno y cuatro meses. Efectos colaterales de poca importancia se observaron úicamente en un animal. Según estos resultados puede concluirse que la Enrofloxacina es un antibiótico excelente para el tratamiento de las piodermas bacterianas del perro, aunque debe administrarse durante un período de tiempo superior al que recomiendan los productores.  相似文献   

Antimicrobial Resistance and Virulence Genes of Campylobacter spp. Isolated from Chicken and Swine Farms in Jiangsu Province     

TANG Mengjun  ZHOU Qian  ZHANG Xiaoyan  ZHANG Jing  TANG Xiujun  LU Junxian  ZHOU Sheng  PU Junhua  GAO Yushi 《畜牧兽医学报》1956,51(9):2284-2292

The aim of this study was to investigate the antimicrobial resistance, virulence genes of Campylobacter spp. isolated from chicken and swine farms in Jiangsu Province. Campylobacter spp. were isolated and identified from two hundred and fifty fecal samples collected from twenty-five animal farms in Jiangsu Province. Campylobacter strains were tested for the antimicrobial susceptibility against to 9 kinds of antimicrobial agents by using an agar dilution method. Eight virulence genes (cdtB, cadF, htrB, clpP, csrA, wlaN, cstⅡ, and cgtB) were detected by polymerase chain reaction. Ninety-three Campylobacter strains were isolated and identified from 250 samples, including 45 C. jejuni strains and 48 C. coli strains. The highest percentage of antimicrobial resistance was found for nalidixic acid (80.0%), tetracycline (71.1%) and ciprofloxacin (66.7%) in C. jejuni isolates. The C. coli isolates were most frequently resistant to erythromycin (87.5%), nalidixic acid (79.2%) and azithromycin (72.9%). Moreover, the multi-drug resistance (resistance to three or more antimicrobial classes) was common among Campylobacter isolates with a rate of 67.7%. On the other hand, the 93 Campylobacter strains showed a wide variation for the presence of the 8 virulence genes, cdtB and cadF were positive for all isolates,while htrB, clpP, csrA, wlaN, cstⅡ and cgtB was 97.8%, 76.3%, 18.3%, 5.4%, 2.2%, and 0%, respectively. The results indicated that the multiple drug resistance of Campylobacter strains from animal origin was relatively serious. In addition, the virulence-associated genes were detected widely among Campylobacter strains.  相似文献   

猪、禽安全生产中主要病原菌耐药性检测及控制技术研究进展   总被引：1，自引：0，他引：1  

王红宁 《四川畜牧兽医》2003,30(Z1):59-60

国内外研究及本课题组的调查表明,猪、禽养殖中主要病原菌的耐药性日趋严重,细菌产生耐药性的机理复杂多样.而药性的检测技术在常规药敏试验的基础上,国内外学者及本课题组已将质粒指纹图谱,PCR,SSCP,核酯探针等分子生物学技术用于耐药性检测.本文还综述和提出了加强兽药管理、制定用药规范、研究质粒消除技术、开发出针对性疫苗、益生素、噬菌体制剂等一系列耐药性的控制技术.  相似文献   

Transcriptome Analysis of Microbiome and Parasites in Feces of Giant Pandas     

DENG Wenwen  LI Caiwu  JIN Lei  LI Guo  WU Honglin  ZHANG Guiquan  WEI Rongping  CHEN Rui  WANG Minglei  HE Yongguo  LI Ti  LI Desheng  ZHANG Hemin  HUANG Yan  ZOU Likou 《畜牧兽医学报》1956,51(11):2812-2824

  相似文献   

广东省某猪场链球菌的分离与鉴定     

郭慧霞  米政实  梁曼怡  王怡飞  徐晓娟  张良  黄永亮 《现代农业科技》2012,(18):269-270,278

为了解广东省茂名某猪场暴发猪链球菌病的详细情况及制作灭活疫苗给猪群接种免疫。该研究通过分离细菌、PCR鉴定、生化试验等方法分离、鉴定细菌,并通过动物试验了解该分离菌的致病性。最后通过药敏试验找出高敏药物用于临床治疗及了解该猪场细菌病的耐药性,指导临床合理用药。  相似文献   

核磁共振技术在枯草芽孢杆菌的抗菌物质结构鉴定中的应用     

商伟伟  蔡良  罗磊  沈加彬  施碧红 《台湾农业探索》2012,(1):67-70

核磁共振(NMR)技术是化合物结构鉴定的一种重要的方法。该文简单介绍了NMR技术的基本原理,及NMR技术在枯草芽孢杆菌所产的多肽、脂肽类抗菌物质结构鉴定中的运用概况,进一步阐述了NMR联用技术的发展现状,展望了其在枯草芽孢杆菌抗菌物的结构鉴定方面的应用前景。  相似文献   

Assessment of yeast cell wall as replacements for antibiotic growth promoters in broiler diets: effects on performance, intestinal histo-morphology and humoral immune responses     

Ghosh TK  Haldar S  Bedford MR  Muthusami N  Samanta I 《Journal of animal physiology and animal nutrition》2012,96(2):275-284

The study compared the effects of an antibiotic growth promoter (AGP), yeast (Saccharomyces cerevisiae) and yeast cell wall (YCW) on performance, microbiology and histo-morphology of the small intestine and humoral immune responses in Ross 308 broilers. The treatments (eight replicates/treatment, n = 12/replicate) were negative control (NC, without AGP), positive control (PC, supplemented with bacitracin methylene disalicylate, 400 mg/kg), Y and YCW (supplemented with yeast and YCW, respectively, 1000 mg/kg). Live weight at 42 days improved (p = 0.086) in the PC, Y and YCW groups. Feed conversion ratio was better (p = 0.039) in the YCW group compared with the other groups. Antibiotic growth promoter in the PC group shortened the villi in duodenum (p = 0.044). Mucosal Escherichia coli number was higher in the PC group (p < 0.001), whereas in the digesta E. coli number was lower (p = 0.001) in the PC, Y and YCW groups in relation to the NC. Mucosal Salmonella populations increased (p = 0.0001) in the PC group, whereas in the digesta, all treatments reduced the Salmonella (p = 0.0001). Following oral challenge with Salmonella pullorum, YCW increased E. coli numbers on the mucosa (p < 0.001) whereas in the digesta the Y group had lower (p < 0.0001) number of E. coli. In the digesta, Salmonella count was lower in the YCW group compared with the other treatments (p < 0.01). Yeast cell wall -treated birds exhibited better (p < 0.05) humoral immune response against Newcastle disease which was far more persistent over time than in any other treatments. It was concluded that the yeast and the yeast cell wall may have effects identical to BMD on performance of broilers and thus may constitute an effective replacement strategy in the dietary regimens for broiler chickens.  相似文献   

Antibiotic use and resistance in animal farming: a quantitative and qualitative study on knowledge and practices among farmers in Khartoum, Sudan     

Eltayb A  Barakat S  Marrone G  Shaddad S  Stålsby Lundborg C 《Zoonoses and public health》2012,59(5):330-338

Antibiotic resistance is a major emerging global public health threat. Farmers in the Khartoum state are believed to misuse antibiotics in animal farming leading to daily exposure to resistant bacteria and antibiotic residues. Hence, farmers are at potential risk exposure to bacteria, zoonotic infection and toxicity. We hypothesized that farmers' misuse of antibiotics could be due to their ignorance of the importance of optimal use of antibiotics, the potential health hazards and the economical waste associated with antibiotic misuse practices. In the present study, we investigated knowledge and practices among farmers regarding antibiotic use and resistance. For this purpose, a cross-sectional study was conducted in Khartoum state where data were collected from 81 farmers using structured interviews. Data were analysed both quantitatively and qualitatively. Fifty-two per cent of farmers were uneducated or had studied for < 6 years. The majority reported antibiotic use for treatment and prevention while only 5% stated use for growth promotion. Antibiotic group treatment for both sick and healthy animals was commonly practiced among most farmers. The most commonly used group of antibiotics was the quinolones, which was reported by one-third. Only 30% of the farmers had heard of antibiotic resistance and provided their definition. Almost half were not aware of the commonly transferred zoonotic infections between humans and animals. The farmers consume 1-2 meals/day from their own farm products. A significant association between low education, poor knowledge of farmers on antibiotic use, antibiotic resistance and zoonotic infections was found. This association may play a vital role in the present practiced misuse of antibiotics. Our findings on farmers' practices could be used as baseline information in defining the gaps related to antibiotic use and resistance in animal farming in Sudan. It can thus serve as a foundation for future interventions.  相似文献   

嗜热链球菌的分离鉴定及牛乳样中抗菌药物残留的检测     

李增魁  黄文明  卓玛 《动物医学进展》2012,33(8):127-130

通过对TTC法中指示菌株嗜热链球菌的分离及分离菌抗生素敏感性的分析,对57份不同来源、不同品牌的牛乳样中抗生素残留进行了检测。结果表明,分离菌对氨苄西林(AMP)耐药;12份牛乳样有抗生素残留,2份乳样可疑;指示菌的耐药性对牛乳中抗生素残留的检测有影响。  相似文献   

蚯蚓抗菌的免疫生态学机制   总被引：1，自引：0，他引：1       下载免费PDF全文

蒋重合  王冲  高凤仙  孙振钧 《家畜生态学报》2012,33(3):7-12

 蚯蚓具有独特的抗菌免疫防御体系,论文从蚯蚓的防御屏障、蚯蚓的细胞免疫和蚯蚓的体液免疫三个方面对蚯蚓的免疫防御体系进行了综述。  相似文献