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Nezu Y Nezu Y Shigihara K Harada Y Yogo T Hara Y Tagawa M 《American journal of veterinary research》2008,69(4):512-518
OBJECTIVE: To determine the effects of intestinal ischemia and reperfusion on the expression of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 mRNAs in the jejunum, liver, and lungs of dogs. ANIMALS: 8 healthy adult Beagles. PROCEDURES: In each dog, the cranial mesenteric artery was occluded for 0 (control group; n=4) or 60 (I-R group; 4) minutes, followed by reperfusion for 480 minutes; serum TNF-alpha and IL-6 activities and expression levels of TNF-alpha and IL-6 mRNAs in jejunal, hepatic, and lung tissues were measured before and at the end of the ischemic period and at intervals during reperfusion. For each variable, values were compared between the control and I-R groups at each time point. RESULTS: Compared with the control group, serum IL-6 activity increased significantly after 180 minutes of reperfusion in the I-R group; also, jejunal TNF-alpha mRNA expression increased significantly after 60 (peak) and 180 minutes of reperfusion. In the I-R group, expressions of IL-6 mRNA in the liver and TNF-alpha and IL-6 mRNAs in the lungs increased significantly at 480 minutes of reperfusion, compared with the control group. Serum TNF-alpha activity, expression of IL-6 mRNA in the jejunum, and expression of TNF-alpha mRNA in the liver in the control and I-R groups did not differ. CONCLUSIONS AND CLINICAL RELEVANCE: Results indicated that the liver, lungs, and jejunum contributed to the production of TNF-alpha and IL-6 after intestinal ischemia and reperfusion in dogs, suggesting that intestinal ischemia and reperfusion induce a systemic proinflammatory cytokine response in dogs. 相似文献
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Ado Shigihara Yuiko Matsumura Kiyoshi Matsumoto Manabu Igawa 《Journal of Forest Research》2009,14(3):188-192
The decline of virgin fir (Abies firma) forest at Mt. Oyama has been reported. Related field observations suggest that high acidity fog is linked with its decline.
However, cedar (Cryptomeria japonica) in the same area shows no symptoms of decline. For assessing effects of acid fog on membrane-bound calcium (mCa) of the
leaf mesophyll cells, 9-year-old seedlings of fir (Abies firma) and 8-year-old seedlings of cedar (Cryptomeria japonica) were exposed twice a week to simulated acid fog (SAF at pH 3 with pH 5 as control) for 2 h per day in a chamber during May–December
2007 (except August). Current and 1-year-old needles were collected from seedlings and analyzed at 1-month intervals. For
current-year needles of fir, mCa levels in cells exposed to SAF at pH 3 were significantly lower than in cells exposed to
pH 5, especially during September 2007–March 2008. In contrast, it is noteworthy that mCa levels of cedar were maintained
as virtually constant irrespective of SAF acidity, indicating that fir is more sensitive to acid fog than is cedar. Based
on these results, mCa loss by acid fog might also be caused in the declining virgin fir forest at Mt. Oyama. 相似文献
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Takahiro Teshima Hirotaka Matsumoto Kae Shigihara Harumi Sawada Masaki Michishita Kimimasa Takahashi Hidekazu Koyama 《The Canadian veterinary journal. La revue veterinaire canadienne》2013,54(9):845-848
A 25-month-old Chihuahua dog with no clinical signs was evaluated for high serum liver enzymes. Ultrasonography and computed tomography revealed a mass in the left hepatic medial lobe. The histological diagnosis reached using resected tissues was hepatocellular carcinoma (HCC). To the authors’ knowledge, this is the youngest dog diagnosed with HCC. 相似文献
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Ado Shigihara Yuiko Matsumura Mayuko Kashiwagi Kiyoshi Matsumoto Manabu Igawa 《Journal of Forest Research》2009,14(6):394-399
The effects of simulated acid fog (SAF) and ozone (O3) stress on the growth and physiology of beech (Fagus crenata) saplings were investigated. Three-year-old beech saplings were exposed to SAFs of pH 3 and pH 5 (control) during May 2007
to July 2008. In each SAF treatment group, half of the saplings were exposed to 60 ppb of O3 during September 2007 to July 2008. In comparison to the control saplings, those from the pH 3 treatment had lower total
plant biomasses, epicuticular wax amounts, Ca2+ concentrations in their leaves, and lower starch concentrations in their leaves and roots. The effect of O3 was significant only for the starch concentration in the roots, but the O3 exposure also negatively affected the growth and physiology of beech saplings. Results show that acid fog exerts various
severe effects, and that both chronic acid fog and O3 exposure suppressed the physiological functions of beech saplings. 相似文献
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Kae Shigihara Nozomi Shimonohara Bryden J. Stanley 《The Canadian veterinary journal. La revue veterinaire canadienne》2021,62(10):1089
A 10-year-old, neutered female, French bulldog was presented with a history of dysuria, hematuria, stranguria, and pollakiuria. Diagnostic tests revealed a large mass at the neck of the bladder without any evidence of metastatic disease. Total cystectomy with bilateral cutaneous ureterostomy creation was elected. Histopathology of the bladder mass revealed extraskeletal osteosarcoma, which was resected completely. Neither recurrence nor metastasis had been detected as of 65 months after surgery. Extraskeletal osteosarcomas are typically malignant and carry a poor prognosis. This is the first report of bladder osteosarcoma in a dog treated by total cystectomy and ureterocutaneostomy with excellent long-term control. 相似文献
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Five open pollinated onion cultivars Red Creole, Kaharda, Koumassa, Sokoto local and Ori were crossed in a complete diallel
and their progenies were evaluated in replicated trials, at Sokoto and Talata Mafara, Nigeria, during the 2004/2005 and 2005/2006
seasons. The experiments were randomised as complete block design with three replications. 30 mls of 10−1 cfu of spore suspension of Alternaria porri prepared by serial dilution was poured into the centre of each plot (sunken bed) immediately after irrigation at 2 weeks
after transplanting. Combined analysis across seasons and locations indicated significant (P < 0.05) differences between the populations with respect to all the characters under study. Crosses Ori × Koumassa and Koumassa × Ori
recorded highly significant (P < 0.01) positive high parent heterosis for bulb diameter. Crosses Ori × Sokoto local and Ori × Koumassa recorded highly significant
(P < 0.01) negative high parent heterosis for days to maturity. Cross Sokoto local × Koumassa exhibited highly significant (P < 0.01) positive high parent heterosis for number of leaves/plant. Crosses Red Creole × Kaharda and Kaharda × Red Creeole
recorded highly significant (P < 0.01) positive high parent heterosis for disease incidence. Red Creole × Kaharda and Kaharda × Red Creeole also recorded
highly significant (P < 0.01) positive high parent heterosis for fresh bulb yield. Cross Kaharda × Ori recorded highly significant (P < 0.01) positive high parent heterosis for bulb weight. The cross Kaharda × Sokoto local recorded significant (P < 0.05) negative high parent heterosis for days to maturity while the cross Red Creole × Kaharda recorded highly significant
(P < 0.01) positive high parent heterosis for number of leaves/plant. Bulb diameter and bulb weight recorded highly significant
(P < 0.01) and significant (P < 0.05) environmental correlation with days to maturity. 相似文献
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