Plant Poisoning in Animals          下载免费PDF全文

Herman J. Boermans 《The Canadian veterinary journal. La revue veterinaire canadienne》1989,30(2):189-190

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Potential hazards     

Herman WA 《Science (New York, N.Y.)》1978,200(4342):643-645

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Molecular modifications of benzylphenol and benzyl-1,3-benzodioxole types of insect chemosterilants     

Gyrgy Matolcsy  Ren Feyereisen  Herman Van Mellaert  gnes Pl  Lszl Varjas  Ivn Blai  Pter Kulcsr 《Pest management science》1986,17(1):13-24

Rationally planned structural modifications were carried out on benzylphenols and benzyl-1,3-benzodioxoles described as fly chemosterilants and as anti-juvenile hormones. The introduction of a prop-2-ynyloxy group at various sites of the molecule resulted in compounds with a moderate inhibitory action on cytochrome P-450 mono-oxygenases, as measured by aldrin epoxidation. One compound, 5-(4-methoxybenzyl)-6-prop-2-ynyloxy-1,3-benzodioxole, revealed chemosterilant activity on Phormia regina, but its activity was less than that of the parent compounds. 2,4-Di-tert-butyl-6-[4-(3-methoxy-3-methylbutoxy)benzyl]phenol, which possessed a juvenoid structure, revealed no juvenile hormone (JH) activity but showed a high sterilant effect against Dysdercus cingulatus. In contrast to the parent substances, none of the tested compounds showed a detectable anti-JH effect in the Galleria assay. 8-Methoxy-2,3-methylenedioxydibenz[b,e]oxepine, a hitherto undescribed fused heterocyclic ring system, was devoid of activity, indicating the importance of free rotation and/or molecular flexibility. In spite of the moderate activities of these compounds, the manifold biological potential of the quinone-methide mechanism justifies further research on these lines.  相似文献   

Panophthalmitis associated with diplococcic septicemia in a rhesus monkey     

P H Herman  J G Fox 《Journal of the American Veterinary Medical Association》1971,159(5):560-562

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Tetralogy of Fallot in a 2-year-old Holstein heifer          下载免费PDF全文

McKenna SL  Barkema HW  McClure JT  Rogers LA 《The Canadian veterinary journal. La revue veterinaire canadienne》2003,44(4):312-313

A 2-year-old, purebred Holstein heifer with exercise intolerance and cardiovascular compromise was diagnosed at postmortem with tetralogy of Fallot, which typically results in death within a few months of life. Survival past the age of 2 was unexpected. The concurrent endocarditis of the pulmonic valve is discussed.  相似文献   

Effect of tilmicosin on chemotactic, phagocytic, and bactericidal activities of bovine and porcine alveolar macrophages     

Brumbaugh GW  Herman JD  Clancy JS  Burden KI  Barry T  Simpson RB  López HS 《American journal of veterinary research》2002,63(1):36-41

OBJECTIVE: To evaluate chemotactic, phagocytic, and bactericidal activities of bovine and porcine alveolar macrophages (AM) exposed to tilmicosin. ANIMALS: 12 healthy calves and 12 healthy pigs. PROCEDURES: Lungs were obtained immediately after euthanasia; AM were collected by means of bronchoalveolar lavage and density gradient centrifugation. Chemotactic activity was evaluated by exposing AM to lipopolysaccharide or macrophage inhibitory peptide during incubation with tilmicosin. Phagocytic activity was evaluated by incubating AM with tilmicosin for 24 hours and then with tilmicosin-resistant Salmonella serotype Typhimurium. Bactericidal activity was evaluated by incubating AM with tilmicosin (0, 10, or 20 microg/ml for bovine AM; 0 or 10 microg/ml or 10 microg/ml but washed free of tilmicosin for porcine AM) and then with Mannheimia haemolytica (bovine AM) or with Actinobacillus pleuropneumoniae or Pasteurella multocida (porcine AM). RESULTS: Tilmicosin had no significant effects on chemotactic or phagocytic activities of bovine or porcine AM. The time-course of bactericidal activity was best described by polynomial equations. Time to cessation of bacterial growth and area under the time versus bacterial number curve were significantly affected by incubation of AM with tilmicosin. CONCLUSIONS AND CLINICAL RELEVANCE: Results show that bactericidal activity of bovine and porcine AM was enhanced by tilmicosin, but not in proportion to the reported ability of AM to concentrate tilmicosin intracellularly. With or without exposure to tilmicosin, the time-course of bactericidal activity of bovine AM against M haemolytica and of porcine AM against A pleuropneumoniae or P multocida was too complex to be reduced to a simple linear equation.  相似文献   

Antibody-induced internalization of viral glycoproteins in pseudorabies virus-infected monocytes and role of the cytoskeleton: a confocal study     

Van de Walle GR  Favoreel HW  Nauwynck HJ  Van Oostveldt P  Pensaert MB 《Veterinary microbiology》2002,86(1-2):51-57

Addition of pseudorabies virus (PrV)-specific polyclonal immunoglobulins to PrV-infected monocytes induces internalization of plasma membrane anchored viral glycoproteins. This process may interfere with antibody-dependent cell lysis and resembles the well-studied physiological endocytosis process. A confocal study was designed to investigate whether the major cellular components, involved in physiological endocytosis (clathrin, actin, dynein and microtubules), play a role in this virological internalization process. In order to visualize the interaction of endosomes, which contain the internalized viral glycoproteins, with clathrin, actin, dynein and microtubules, a double labeling of viral glycoproteins and different cellular proteins was performed. Porcine monocytes were inoculated with the PrV-strain 89V87 at a multiplicity of infection of 50 for 13h. After the addition of FITC-labeled porcine polyclonal PrV-specific antibodies, cells were fixed with para-formaldehyde at different time points and afterwards permeabilized. The different cellular components were visualized with monoclonal antibodies and a Texas Red-conjugate, with the exception of actin, which was stained with phalloidin-Texas Red. The cells were analyzed by confocal microscopy. A clear co-localization was observed between the viral glycoproteins and clathrin and dynein during the internalization process. The microtubules were in close contact with the internalized vesicles. For actin no co-localization could be observed. It can be stated that clathrin, dynein and microtubules, important components during physiological endocytosis, are also of importance during the antibody-induced internalization of viral glycoproteins.  相似文献   

Biological performance of a formulation containing water-dispersible copper naphthenate and sodium fluoride against decay fungi     

Donatien Pascal Kamdem  Nzokou Pascal  Doug Herman  Zuju Shu 《Wood material science & engineering》2020,15(1):30-36

ABSTRACT

Two formulations of wood preservative one containing water-dispersible copper naphthenate (CuN) alone and in combination with sodium fluoride (NaF) were used to treat southern pine sapwood blocks to determine the effect of the addition of sodium fluoride in the QNS on the protection against wood decay fungi using laboratory soil block tests following AWPA (American Wood protection Association) standard E10-16 [American Wood Protection Association AWPA-E10. (2016 American Wood Protection Association. (2016) Standard E10-16 Laboratory Method for Evaluating the Decay Resistance of Wood-Based Materials Against Pure Basidiomycete Cultures: Soil/Block Test. [Google Scholar]) Laboratory Method for Evaluating the Decay Resistance of Wood-based Materials Against Pure Basidiomycete Cultures: Soil/Block Test]. The standard consists in exposing treated blocks to pure monoculture of white rot (Irpex lacteus (FP-105915) and Trametes versicolor (R-105)) and brown rot fungi (Gloeophyllum trabeum (Madison 617) and Postia placenta (Madison 698) during a specific period. The weight loss (WL) in percentage of treated blocks was used as an indicator of the biological performance of treated blocks against basidiomycetes at specific retentions. Minimum WL was obtained with blocks treated with the formulation containing mixture of QNS and sodium fluoride with the retention of 0.29?kg/m³ Cu and 0.51?kg/m³ of fluorine in treated blocks. A copper retention of 1.65?kg/m³ from blocks treated with formulations containing only QNS was needed to obtain similar WL to blocks containing blocks Cu++ and F? (fluorine). The lower Cu retention is attributed to a combination of the presence of the fluorine with some toxic activities against bacteria and decay and the interaction of anions fluorine and ionic Cu (II) in the aqueous treating solutions to form more soluble biological toxic hydrate of copper fluoride ((H₂O Cu (II) F2) in treated blocks compared to copper complexes less biological available in water-dispersible CuN-treated bocks.  相似文献   

The origins and lineage of One Health,Part I     

Justin Ancheta  Raad Fadaak  R. Michele Anholt  Danielle Julien  Herman W. Barkema  Myles Leslie 《The Canadian veterinary journal. La revue veterinaire canadienne》2021,62(8):883

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Genetic diversity of livestock-associated MRSA isolates obtained from piglets from farrowing until slaughter age on four farrow-to-finish farms     

Marijke Verhegghe  Florence Crombé  Larissa J Pletinckx  Freddy Haesebrouck  Patrick Butaye  Lieve Herman  Marc Heyndrickx  Geertrui Rasschaert 《Veterinary research》2014,45(1)

During a previous longitudinal study, performed on four farrow-to-finish farms (A to D), samples were taken from twelve sows, their offspring, and the environment on various occasions over six months to study the MRSA presence. During the present study, a selection of the obtained MRSA isolates were typed by multiple-locus variable-number tandem-repeat analysis (MLVA), Pulsed Field Gel Electrophoresis (PFGE), spa typing, and SCCmec typing to study the genetic diversity of LA-MRSA isolates and to determine possible MRSA sources for pig(let)s. PFGE, spa typing, and SCCmec typing revealed the presence of one or few dominant genotype(s) per farm. In contrast, 212 MLVA types were detected on the four farms, forming one cluster on farm A, three on farm B, four on farm C and two on farm D. The genotype, found on farm A was unique for this farm. Farms B, C and D shared one cluster. In general, MLVA types from these clusters were isolated from piglets, sows, and the environment on various sampling events. Piglets carried MLVA types both related and unrelated to their mother sows’ MLVA types at farrowing and onwards. In conclusion, molecular typing revealed that within a farm one or a few dominant strain(s) are widespread. Potential MRSA sources for piglets were mother sows, the environment and other piglets.

Electronic supplementary material

The online version of this article (doi:10.1186/s13567-014-0089-4) contains supplementary material, which is available to authorized users.  相似文献