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1.
Strips of rumen wall from bovine fetuses were incubated in an organ bath with prostaglandin F2 alpha (0.13 to 33.76 g/ml). The highest reactivity with a submaximal dose (17.03 g/ml) was observed in the period between 3.0 and 7.9 months of fetal age. A smaller response, but higher than in 1.0 to 2.9 months old fetuses, was observed in the 8.0 to 8.9 months fetuses. The period of the highest reactivity to prostaglandin F2 alpha coincides with the age of onset of papillary morphogenesis and the period of highest reactivity to autonomic and putative transmitter drugs. 相似文献
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Questionnaire‐based Analysis of Owner‐reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari‐like Malformation and Syringomyelia 下载免费PDF全文
C.R. Sparks S. Cerda‐Gonzalez E.H. Griffith B.D.X. Lascelles N.J. Olby 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(1):331-339
Background
Chiari‐like malformation (CM) and syringomyelia (SM) cause a pain syndrome in Cavalier King Charles spaniels (CKCS). Clinical signs are not consistently apparent on neurologic examination, and owner reporting of signs provides vital clinical history. However, owner questionnaires for this disease are not well developed.Objectives
To develop a tool to capture owner‐reported clinical signs for use in clinical trials and to compare owner‐reported signs with the presence of pain on neurologic examination and SM on magnetic resonance imaging (MRI).Animals
Fifty client‐owned CKCS.Methods
Owners completed a questionnaire and pain/scratch map. Each dog underwent a neurologic examination and craniocervical magnetic resonance imaging (MRI). Questionnaire responses were developed into scores, area of shading for pain/scratch maps was measured, and consistency of responses between these tools was assessed. Owner‐reported findings were compared with neurologic examination findings and presence and severity of SM on MRI.Results
Thirty‐three dogs were symptomatic and 17 asymptomatic; 30 had SM. The most common sign of pain was crying out when lifted (n = 11). Extent of shaded areas on maps positively correlated with questionnaire scores for pain (r2 = 0.213, P = 0.006) and scratch (r2 = 0.104, P = 0.089). Owner‐reported findings were not significantly associated with presence or severity of SM or neurologic examination findings. Owner‐reported lateralization of signs was significantly associated with SM lateralization (P < 0.0001).Conclusions
The questionnaire and maps may be useful for clinical trials. Lack of association of owner‐reported signs with SM highlights our lack of understanding of the pathophysiology of pain in this disease. 相似文献4.
Identification of genic SSRs in jute (Corchorus capsularis,Malvaceae) and development of markers for phenylpropanoid biosynthesis genes and regulatory genes 下载免费PDF全文
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J. M. Mirás Avalos I. Bertol P. Sande Fouz C. Carballeira Díaz E. Vidal Vázquez & A. Paz Gonzalez 《Soil Use and Management》2009,25(2):193-200
Tillage practices may reduce the organic matter content in near-surface soil horizons causing crust formation. Surface conditions may cause an increase in surface run-off, thus enhancing contaminant transfer of heavy metals or an acceleration in nutrient loss. This study examines the effect of applying crop residues to the surface of tilled soils on heavy metal losses by run-off. Losses in iron (Fe), manganese (Mn), zinc (Zn) and copper (Cu) were analysed. Run-off and sediment yield were measured on 1 m2 plots using a rainfall simulator with a constant 65 mm/h intensity. Four successive rainfall applications were performed, the first three at 25 mm each and the last at 65 mm. Added corn straw varied between 0 and 4 t/ha in the five studied treatments. After 140 mm cumulative rainfall, total heavy metal losses were as follows: Fe from 137 to 950 mg/L, Mn from 2.3 to 12.83 mg/L, Cu from 0.09 to 0.72 mg/L and Zn from 0.31 to 2.46 mg/L. Dissolved fractions were as follows: Fe from 0.014 to 0.229 mg/L, Mn from 0.034 to 1.45 mg/L, Cu from 0.002 to 0.013 mg/L and Zn from 0.02 to 0.12 mg/L. Total concentrations of the studied elements decreased exponentially due to the effect of corn straw on soil loss. However, dissolved contents of Fe and Cu scarcely varied. Significant positive linear correlations were observed between total heavy metal content and soil and sediment loss by run-off. It is concluded that the addition of straw to a soil of low fertility prevents heavy metal loss. 相似文献
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García ME Caballero J Toni P Garcia I Martinez de Merlo E Rollan E Gonzalez M Blanco JL 《Journal of veterinary medicine. A, Physiology, pathology, clinical medicine》2000,47(4):243-249
We describe a case of canine mycoses initially diagnosed by clinical signs and enzyme-linked immunosorbent assay anti-fungal test, and later confirmed by the isolation of Paecilomyces sp. during the post-mortem examination. The fungus was isolated from lesions in the kidneys, mitral valve, abdominal aorta and vertebral discs. In this kind of process, it is important to identify the responsible agent early in order to make a study of anti-fungal susceptibility and establish effective treatment. 相似文献
9.
Thaliblastine exhibits dose dependent cytotoxic effect on HL-60, HL-60/DOX, RHE and HD-MY-2 leukemia cells. Additionally, typical for apoptosis oligonucleosomal DNA fragmentation could be detected in leukemia cells treated with thaliblastine. Moreover, an MDR-phenotype reversing effect of thaliblastine was also identified. 相似文献
10.
A. Wójciak M. Sikorski R. Gonzalez J. L. Bourdelande F. Wilkinson 《Wood Science and Technology》2002,36(3):187-195
The diffuse-reflectance laser-flash photolysis method together with ground state diffuse reflectance spectroscopy have been
used to study the effect of pH and temperature of the hydrogen peroxide treatment on oxygen delignified softwood kraft pulp.
Received 20 December 1999 相似文献