Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells     

Illies C  Gromada J  Fiume R  Leibiger B  Yu J  Juhl K  Yang SN  Barma DK  Falck JR  Saiardi A  Barker CJ  Berggren PO 《Science (New York, N.Y.)》2007,318(5854):1299-1302

Inositol pyrophosphates are recognized components of cellular processes that regulate vesicle trafficking, telomere length, and apoptosis. We observed that pancreatic beta cells maintain high basal concentrations of the pyrophosphate diphosphoinositol pentakisphosphate (InsP7 or IP7). Inositol hexakisphosphate kinases (IP6Ks) that can generate IP7 were overexpressed. This overexpression stimulated exocytosis of insulin-containing granules from the readily releasable pool. Exogenously applied IP7 dose-dependently enhanced exocytosis at physiological concentrations. We determined that IP6K1 and IP6K2 were present in beta cells. RNA silencing of IP6K1, but not IP6K2, inhibited exocytosis, which suggests that IP6K1 is the critical endogenous kinase. Maintenance of high concentrations of IP7 in the pancreatic beta cell may enhance the immediate exocytotic capacity and consequently allow rapid adjustment of insulin secretion in response to increased demand.  相似文献   

Evaluation of elite bread wheat lines for resistance to blast disease in Bangladesh     

Roy  Krishna Kanta  Reza  Md Mostofa Ali  Muzahid-E-Rahman  Md  Anwar  Md Babul  Kishowar-E-Mustarin  Kabir  Muhammad Rezaul  Malaker  Paritosh Kumar  Barma  Naresh Chandra Deb  Hossain  Md Israil  He  Xinyao  Chawade  Aakash  Singh  Pawan Kumar 《Euphytica》2021,217(7):1-23

Euphytica - Genetic approaches often lead to the most cost-effective and efficient means to improve crops, especially those grown widely. But for most crops, cotton included, genetic improvement...  相似文献