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排序方式: 共有74条查询结果,搜索用时 812 毫秒
1.
Rina Yamane Makoto Tanaka Nao Kikugawa Hideki Yasui Kenta Takei Miwa Harada Shinya Kaneda 《Journal of toxicologic pathology》2021,34(1):127
The pathological effects of copper deficiency (COD) are well known. However, the pathogenesis of cardiomyopathy resulting from COD remains unclear. In this study, aimed to elucidate the pathogenesis of COD-induced cardiomyopathy by examining the morphology of the cardiovascular system in copper-deficient rats using histopathology, immunohistochemistry, and scanning and transmission electron microscopy. Changes detected in the myocardium and interstitium were consistent with those reported for COD. Morphological changes included mesh-like changes in the capillary endothelial cells that appear to be a novel finding in COD-induced cardiomyopathy. These changes are hypothesized to result from abnormal vascular remodeling following damage to the basement membrane and due to the mechanical effects of myocardial contractions. Although cardiomyopathy may be associated with microcirculatory disorders arising from these lesions, further investigations are necessary to demonstrate a causal relationship between the pathogenesis of cardiomyopathy and the contribution of these lesions to disease progression. 相似文献
2.
Kumagai R Nakatani K Ikeya N Kito Y Kaidoh T Takeuchi S 《Veterinary microbiology》2007,122(1-2):190-195
In 13 of 43 non-beta-hemolysin-producing bovine isolates of Staphylococcus aureus, two truncated beta-hemolysin (hlb) genes were demonstrated by PCR and sequencing, and one truncated hlb gene was located beside the integrase (int) gene of phage origin. The staphylokinase (sak) gene was detected in all 13 isolates in which the truncated hlb genes were detected by PCR. Enterotoxin A (sea) and enterotoxin P (sep) genes were also detected in 5 and 2 of the 13 isolates, respectively. Moreover, the scn and chp genes encoding staphylococcal complement inhibitor (SCIN) and chemotaxis inhibitory protein of S. aureus (CHIPS) were detected in 13 and 4 of the 13 isolates, respectively. The bacteriophage induced by mitomycin C treatment was able to lysogenize one beta-hemolysin-producing isolate of S. aureus, and the sak and scn genes were detected from the lysogenized isolate. These results suggest quadruple or quintuple conversion of hlb, sak, sea (or sep), scn, and chp genes by bacteriophages among non-beta-hemolysin-producing bovine isolates of S. aureus. 相似文献
3.
A. HüTtermann Marie-Therese Oelbe E. Fritz G. Schlechte A. Bytom A. D. Jungk Y. Okon E. Fallik Rivka Hadas S. Sarig E. Yahalom Sara Tal A. Hartmann B. Kishinevsky Debora Gurfel Rina Lobel Y. Kapulnik D. A. Phillips Y. Hadar Y. Chen E. Jurkevitch J. Katan A. Gamliel H. Ziegler I. Chet A. Ordentlich Hadar Kless A. Oppenheim Avia Zilberstein D. Holland J. Berman A. Zamir R. Kaufman N. Bawnik C. Koncz J. Schell 《Phytoparasitica》1987,15(2):141-147
4.
5.
牛奶来源质量监督调查报告 总被引:2,自引:0,他引:2
为保证牛奶来源的质量和食品安全,对42个牧场进行随机检查,发现挤奶环境差、现场管理不当、人为搀假问题严重.其中酒精实验不合格和干物质低的牛奶数量最多,酒精阳性奶共48.27 t,干物质低奶54.36 t,分别占总问题奶的37%和44%.希望引起广大奶牛养殖户和乳品企业的重视. 相似文献
6.
The cytological status of plantlets regenerated from shoot apical meristems of Pisum sativum was investigated. Chromosome counts in root apices of in vitro regenerated plants showed a preponderance of diploid cells. Moreover, the karyotypes of root-tips from plants derived from culture and from normal plants were basically the same. Topics such as the treatment of chromosomal armlength data, simple statistical comparison of samples derived from normal and regenerated plants are discussed. 相似文献
7.
Our recent study demonstrated the potential of gastric fluid at pH 3.0 to accelerate lipid peroxidation and cooxidation of dietary constituents in the stomach medium. Metmyoglobin is known to catalyze the breakdown of lipid hydroperoxides to free radicals, a reaction that could enhance the propagation step and general lipid peroxidation. During this reaction, a part of the free radicals is autoreduced by metmyoglobin. At pH 3.0, metmyoglobin at low concentration was almost 7 x 10(4) times as effective as at pH 7.0 in enhancing the rate of lipid peroxidation. Our study demonstrated that metmyoglobin, at a low concentration (approximately 1:30), as compared with that of the hydroperoxides in the lipid system, worked prooxidatively increasing the amounts of linoleate hydroperoxides. However, at a high concentration (approximately 1:3), metmyoglobin acted antioxidatively and decomposed hydroperoxides, whose concentrations then remained at zero for a long time. Catechin, a known polyphenol, supports the inversion of metmyoglobin catalysis, from prooxidation to antioxidation. The antioxidative activity of the couple metmyoglobin-catechin was better at pH 3.0 than at pH 7.0, indicating that this reaction is more dependent on metmyoglobin than on catechin. During this reaction, catechin or quercetin not only donates reducing equivalents to prevent lipid peroxidation but also prevents the destruction and polymerization of metmyoglobin. The results of this research highlighted the important and possible reactions of heme proteins and polyphenols as couple antioxidants, working as hydroperoxidases or as pseudo-peroxidases. We hypothesize that the occurrence of these reactions in the stomach could have an important impact on our health and might help to better explain the health benefits of including foods rich in polyphenol antioxidants in the meal, especially when consuming red meat. 相似文献
8.
Rina KIHARA Yoshinori KASASHIMA Katsuhiko ARAI Yasunori MIYAMOTO 《Journal of Equine Science》2011,22(3):57-60
Injury initiates a repair process characterized by influx of fibroblasts and the rapid
formation of fibrous scar tissue and subsequent tissue contraction. The response to injury
and behavior of the different tendon fibroblast populations, however, has been poorly
characterized. We hypothesized that the fibroblasts recovered from tendon with acute
injury would exhibit different cell properties relating to adhesion, migration and
tensegrity. To test this hypothesis we evaluated the ability of fibroblasts recovered from
normal and injured equine superficial digital flexor tendons (SDFTs). The injured
tendon-derived cells showed greater contraction of the collagen gel but poorer adhesion to
pepsin-digested collagen, and migration over extracellular matrix proteins compared to
normal SDFT-derived fibroblasts. Thus, the cells present within the tendon after injury
display different behavior related to wound healing. 相似文献
9.
Uyama R Hong SH Nakagawa T Yazawa M Kadosawa T Mochizuki M Tsujimoto H Nishimura R Sasaki N 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2005,67(12):1273-1276
Eight new feline mammary adenocarcinoma cell lines derived from either primary or metastatic lesions were established. The morphology of all the cell lines was epithelioid and round to spindle in shape, with cell growth occurring in a monolayer fashion. On immunohistochemistry, these cells reacted with anti-keratin and anti-vimentin antisera. The doubling time of these cells was between 19 and 54 hr. Tumor masses were developed in nude mice by subcutaneous inoculation of the cells that were histologically identical to their original mammary tumor lesions. Telomerase activities measured using the telomeric repeat amplification protocol assay revealed high telemetric activity in all of the cells. 相似文献
10.
Azakami D Bonkobara M Washizu T Iida A Kondo M Kato R Niikura Y Iwaki S Tamahara S Matsuki N Ono K 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2006,68(12):1343-1346
Seven novel cell lines from canine histiocytic sarcoma (HS), three of which were disseminated cutaneous HS and four of which were synovial HS, were established. All of the established cell lines had the same morphological (by light and electron microscopic findings), cytochemical (alpha-naphthyl butyrate esterase-positive), and immunohistochemical (vimentin- and lysozyme-positive, and cyto-keratin-negative) characteristics as the original HS tumor cells. All of the established cell lines injected into nude mice subcutaneously produced solid tumors. Because the established cell lines also showed phagocytic and processing activities, the HS tumor cells appear to originate from the mononuclear phagocytic system cells, despite their differences in locations or organs. 相似文献