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Jeong O-Young Park Hyeon-Su Baek Man-Kee Kim Woo-Jae Lee Geon-Mi Lee Chang-Min Bombay Maurene Ancheta Melanie Banzon Lee Jeom-Ho 《Journal of Crop Science and Biotechnology》2021,24(1):1-11
Journal of Crop Science and Biotechnology - Rice has been grown as a staple food in South Korea for several millennia. However, its status has not stayed constant as a result of changes in South... 相似文献
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The production of transgenic farm animals(e.g., cattle) via genome engineering for the gain or loss of gene functions is an important undertaking. In the initial stages of genome engineering, DNA micro-injection into one-cell stage embryos(zygotes) followed by embryo transfer into a recipient was performed because of the ease of the procedure.However, as this approach resulted in severe mosaicism and has a low efficiency, it is not typically employed in the cattle as priority, unlike in mice. To overcome the above issue with micro-injection in cattle, somatic cell nuclear transfer(SCNT) was introduced and successfully used to produce cloned livestock. The application of SCNT for the production of transgenic livestock represents a significant advancement, but its development speed is relatively slow because of abnormal reprogramming and low gene targeting efficiency. Recent genome editing technologies(e.g.,ZFN, TALEN, and CRISPR-Cas9) have been rapidly adapted for applications in cattle and great results have been achieved in several fields such as disease models and bioreactors. In the future, genome engineering technologies wil accelerate our understanding of genetic traits in bovine and wil be readily adapted for bio-medical applications in cattle. 相似文献
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