Stereotactic radiation therapy for treatment of canine intracranial meningiomas          下载免费PDF全文

L.R. Griffin  M.W. Nolan  L.E. Selmic  E. Randall  J. Custis  S. LaRue 《Veterinary and comparative oncology》2016,14(4):e158-e170

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Outcome following treatment of vertebral tumors in 20 dogs (1986-1995)     

Dernell WS  Van Vechten BJ  Straw RC  LaRue SM  Powers BE  Withrow SJ 《Journal of the American Animal Hospital Association》2000,36(3):245-251

Twenty dogs with histopathologically confirmed primary (n=15) or metastatic (n=5) osteosarcoma (n=14) or fibrosarcoma (n=6) of the vertebral column were treated with surgery (n=4), radiation therapy and chemotherapy (n=6), surgery and chemotherapy (n=2), or surgery, radiation, and chemotherapy (n=8). All dogs died due to their disease; 15 died due to local failure, and five died due to nonvertebral metastasis. Overall median survival time was 135 days, with a range of 15 to 600 days. Of the factors evaluated, only postoperative neurological status had a significant influence on outcome by multivariate analysis. This study supports the overall guarded prognosis for dogs with vertebral neoplasia. Better combinations of surgery, chemotherapy, and radiation therapy remain to be defined for this difficult subset of animal cancer.  相似文献   

Proteomic analysis and differential expression in protein extracted from chicken with a varying growth rate and water-holding capacity     

Phongpa-Ngan P  Grider A  Mulligan JH  Aggrey SE  Wicker L 《Journal of agricultural and food chemistry》2011,59(24):13181-13187

Chickens from a randomly bred genetic line were segregated into high and low growth rates and high and low water-holding capacities (WHCs). The objective of this study was to identify protein markers associated with slow and fast growth rates and low and high WHCs from water-soluble protein (WSP) and crude myofibrillar protein (CMP) extracts of chicken breast muscle. Proteins were fractionated using two-dimensional electrophoresis, and a total of 22 protein spots were selected, excised, and analyzed by in-gel tryptic digestion and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proteins expressed in extracts from slow and fast growth rates and low and high WHCs included metabolic enzymes, such as creatine kinase, pyruvate kinase, triosephosphate isomerase, and ubiqitin; housekeeping proteins, such as heat shock protein; contractile proteins, such as myosin heavy chain; actin; and also MHC isoforms and actin isoforms. The mass spectra of 20 protein spots significantly matched (protein score >83; P < 0.05) an online database. In CMP, there were unique proteins that were present only in the fast-growth population: gi|118099530 , gi|20664362 , gi|71895043 , gi|114794125 , gi|297343122 , and gi|71895043 . This information identified protein markers associated with growth rate and water holding capacity. Some of those protein markers could be added to the chicken database.  相似文献   

营养和培养参数对深层培养灵芝生产多糖的影响     

马登波  TANG Jake K-W  BUSWELL John A  张树庭 《食用菌学报》2011,18(1)

研究了各种营养成分和培养参数(pH,温度,氮源可利用性,C∶N,搅拌速度,接种量)对在生物反应器可控条件下利用合成培养基深层培养灵芝生产多糖的影响.所生产的多糖大部分(通常80%以上)为胞外多糖(EPS),分泌到培养液中,菌丝多糖(MAP)只占不到20%.在pH5.0条件下,总多糖(EPS和MAP)生产量和菌丝生长量最高.在28～34℃范围内,多糖产量在34℃培养条件下最高,并随着温度降低而下降.低氮条件下,菌丝生长较弱,多糖产量较低.多糖生产量(主要是胞外多糖)随着接种量的增加而提高,菌丝多糖的生产则相反.利用高效液相色谱(HPLC)凝胶层析法分离出两个胞外多糖组分,其洗脱时间为26.5和36.5 min,分子量分别为137和4.7 kDa;菌丝多糖有一个大的峰(40 min)和一个很小的峰(28 min),其分子量分别为1.57和76.6 kDa.菌丝多糖的HPLC凝胶层析色谱和从灵芝子实体中提取的多糖相似.本研究所采用的各种培养条件下生产的多糖(EPS和MAP)具有可重复性的HPLC色谱.  相似文献   

Soft tissue sarcomas in dogs     

Mayer MN  LaRue SM 《The Canadian veterinary journal. La revue veterinaire canadienne》2005,46(11):1048, 1050, 1052

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Working with waste. More treasure than trash. Introduction     

N Wigginton  J Yeston  D Malakoff 《Science (New York, N.Y.)》2012,337(6095):662-663

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REPEATABILITY OF A PLANNING TARGET VOLUME EXPANSION PROTOCOL FOR RADIATION THERAPY OF REGIONAL LYMPH NODES IN CANINE AND FELINE PATIENTS WITH HEAD TUMORS     

Hiroto Yoshikawa  Joseph F. Harmon  James T. Custis  Susan M. LaRue 《Veterinary radiology & ultrasound》2012,53(6):667-672

For canine and feline patients with head tumors, simultaneous irradiation of the primary tumor and mandibular and retropharyngeal lymph nodes (LNs) is often indicated. The purpose of this study was to assess the repeatability of a planning target volume (PTV) expansion protocol for these LNs. Two CT image sets from 44 dogs and 37 cats that underwent radiation therapy for head tumors were compared to determine LN repositioning accuracy and precision; planning‐CT (for radiation therapy planning) and cone‐beam CT (at the time of actual treatment sessions). Eleven percent of dogs and 65% of cats received treatment to their LNs. In dogs, the mandibular LNs were positioned more caudally (P = 0.0002) and the right mandibular and right retropharyngeal LNs were positioned more to the left side of the patient (P = 0.00015 and P = 0.003, respectively). In cats, left mandibular LN was positioned higher (toward roof) than the planning‐CT (P = 0.028). In conclusion, when the patient immobilization devices and bony anatomy matching are used to align the primary head target and these LNs are treated simultaneously, an asymmetrical PTV expansion that ranges 4–9 mm (dogs) and 2–4 mm (cats), depending on the directions of couch movement, should be used to include the LNs within the PTV at least 95% of the time.  相似文献   

Treatment of leiomyosarcoma in a tiger (Panthera tigris) with stereotactic radiotherapy     

Bonnie B. Boudreaux  Susan M. LaRue  Nathalie Rademacher  Daniel Neck  Britton Grasperge  Charles Wood  David G. Baker 《Veterinary radiology & ultrasound》2019,60(3):E33-E37

A 10‐year‐old male captive tiger (Panthera tigris) developed right‐sided facial asymmetry and enlargement. Computed tomography revealed a destructive mass of the right maxillary bone with right nasal cavity involvement. Histopathology indicated a spindle cell sarcoma. A single fraction of 22 Gy using stereotactic radiotherapy was prescribed. After treatment, the facial conformation returned to normal and the tiger resumed normal behavior. Diagnostics 4 months later indicated severe metastatic disease. Humane euthanasia and necropsy were performed. This is the first case utilizing stereotactic radiotherapy for the treatment of cancer in a tiger.  相似文献   

Correlations between acute radiation scores and pain scores in canine radiation patients with cancer of the forelimb     

Carsten RE  Hellyer PW  Bachand AM  LaRue SM 《Veterinary anaesthesia and analgesia》2008,35(4):355-362

Objective To determine whether there is a correlation between skin acute radiation score (ARS) and pain scores and to determine if skin ARSs can be used to predict future pain scores and increased need for analgesia in dogs undergoing radiation therapy for cancer of the forelimb. Study design Prospective observational study. Animals Seven middle‐aged dogs of various breeds with cancer of the forelimb. Methods Each neoplasm was surgically removed and a histologic diagnosis was obtained. Curative intent radiation therapy was initiated 2½–4½ weeks after surgery. Curative intent radiation therapy was delivered as prescribed. Two trained observers scored the dogs using a visual analog pain scale (VAS), Glasgow composite measure of pain scale, short form (GCMPS) and skin ARS prior to each day’s therapy. Daily scores were averaged and scatter plots were developed. Generalized estimating equation regressions were used to calculate standard error, 95% confidence interval, and p‐values for each relationship. Confidence and prediction bands were plotted. Results A statistically significant correlation between skin ARS and VAS and GCMPS pain scores was identified indicating that as the skin ARS increased so did the pain scores. A general correlation between VAS and GCMPS scores was observed. Early (fraction days 1–6) GCMPS scores were significantly influenced by anxiety behavior unrelated to pain. Skin ARS was found to predict precisely current and future presence of pain, but could only predict a range of potential future pain scores based on the pain management approach in use during this study. Conclusions Skin ARS can provide valuable information for initiating preemptive analgesia and intensifying pain management during curative intent radiation therapy. Daily pain scoring with an acceptable pain scale should be used in conjunction with the skin ARS to improve patient pain management. Clinical relevance Pain is an anticipated consequence of curative intent radiation therapy. Understanding the correlation between pain and skin ARS may facilitate more effective pain management.  相似文献   

High field magnetic resonance imaging contributes to diagnosis of equine distal tarsus and proximal metatarsus lesions: 103 horses          下载免费PDF全文

Myra F. Barrett  Kurt T. Selberg  Sherry A. Johnson  Jake Hersman  David D. Frisbie 《Veterinary radiology & ultrasound》2018,59(5):587-596

Injury of the distal tarsus and proximal metatarsus commonly causes lameness. Magnetic resonance imaging (MRI) allows concurrent assessment of both the distal tarsal joints and suspensory ligament origin, and aids identification of lesions that may otherwise go undetected by other modalities. In this retrospective observational study, the medical records of a veterinary imaging center were searched for MRI exams of the distal tarsus and proximal metatarsus for the years 2012 through 2014. Studies for 125 limbs of 103 horses were identified and retrospectively evaluated by two board‐certified veterinary radiologists. Soft tissue and osseous changes were characterized and graded by degree of severity. The patients’ signalment, lameness severity, and results of diagnostic analgesia were recorded. Osteoarthritic changes of the distal intertarsal and tarsometatarsal joints were the most common findings. Other findings included bone marrow lesions, degenerative changes of the small cuboidal bones, subchondral cystic lesions, and intertarsal desmopathy. Suspensory ligament desmopathy was found in 53% of limbs. Fourty‐seven percent of limbs that responded to analgesia of the proximal suspensory ligament had more severe lesions in the distal tarsus. Bone marrow lesions of the third tarsal bone were the only MRI finding that correlated with grade of lameness in patients for which lameness grade was reported. The grade of lameness has a poor correlation with the severity of lesions found on MRI. The findings support the use of MRI for simultaneous evaluation of the proximal metatarsus and distal tarsus, particularly given the difficulty of lesion localization with diagnostic analgesia.  相似文献