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Deb Manas Kanti Thakur Manisha Mishra R. K. Bodhankar Ninad 《Water, air, and soil pollution》2002,140(1-4):57-71
An assessment of arsenic contamination in Raipur city (21°14′N, 18°38′E) of Chhattisgarh in the central part of India is reported here, for a monitoring period between November 1996 to June 1997, in airborne dust particulates. The concentration level of As were higher in the industrial site, followed by heavy traffic as compared to other sites. The monthly atmospheric arsenic deposition, in μg As per g of dust fall, of 6 sites are in the range of 0.100(μ0.020)–4.00(μ0.020); site no. 1 industrial area, 0.100(μ0.020)–0.320(μ0.020); site no. 2 residential area, 0.044(μ0.070)–0.337(μ0.030); site no. 3 commercial area, 0.093(μ0.068)–1.870(μ0.020); site no. 4 residential area, 0.111(μ0.020)–1.912(μ0.010); site no. 5 residential area and 0.068(μ0.040)–3.037(μ0.060); site no. 6 heavy traffic area. The total annual flux of As in the fall-out at different zones is in the range 0.033–1.12 kg km-2 yr-1. The month wise collection and analysis of dust fall out rate between 3.0(μ0.10)–91.3(μ1.4) mt (metric tonnes) km-2 month-1 were observed at all 6 sampling sites. Anthropogenic and environmental factors play important roles in the contribution of arsenic in airborne particulate matters. 相似文献
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Background: Diabetes mellitus is an alarming life style disease in the modern world. Exploitation of the anti-diabetic drugs for the amelioration of diabetes and associated life style diseases has become an imperative concern. In this milieu, this study was designed to explore the plausible effects of metformin intervention on hepatic and renal functions in a rat model of alcoholic liver disease. Methods: Thirty rats were divided into five groups (n = 6): ethanol control, ethanol water and also low, moderate and high doses of metformin. Ethanol 20% v/v (1 ml/100 g) was administered by oral gavage to all five groups for 21 days. Blood and tissue samples were collected for the assessment of lipid profile, hepatic and renal functions. Results: After 21 days, the levels of hepatic function and lipid parameters were maintained at normalcy, especially in the high-dose metformin treated alcoholic rats as compared to the levels at day 1. Despite this, the renal biomarkers did not display any significant variation due to ethanolic exposure in any group. The histopathological score portrayed that the noxious effect of ethanol is prevented in the liver of moderate- and high-dose metformin, whereas the renal histological scores were unchanged in all the groups including ethanol control. Conclusion: These results suggest that the dose of ethanol required to induce hepatic dysfunction does not influence renal functions. In addition, high-dose metformin offers maximal hepatoprotection and spares kidney from per se toxicity, thereby advocating the beneficial intervention of the anti-diabetic drug, metformin, in alcoholic liver dysfunction. Key Words: Ethanol, Metformin, Kidney 相似文献
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Diabetes mellitus is a serious debilitating epidemic affecting all social strata in developing as well as developed countries. Diabetic neuropathy is most common of secondary complications associated with diabetes mellitus and is characterized by slowing of nerve conduction velocity, elevated pain, sensory loss and nerve fiber degeneration. The aim of the present investigation was to evaluate the neuroprotective effect of naringin against streptozotocin (STZ) induced diabetic neuropathic pain in laboratory rats. Four weeks after intraperitoneal injection of STZ resulted in significant decrease in mechano-tactile allodynia, mechanical hyperalgesia, thermal hyperalgesia and motor nerve conduction velocity. Activity of endogenous antioxidant like superoxide dismutase as well as membrane bound inorganic phosphate enzyme was also found to be significantly decreased. It not only caused neural cell apoptosis but also enhanced lipid peroxide, nitrite, and inflammatory mediators' (TNF-α) level. Chronic treatment with naringin (40 and 80mg/kg) for 4 weeks significantly and dose dependently attenuated the decrease in level of nociceptive threshold, endogenous antioxidant and membrane bound inorganic phosphate enzyme. It also decreased the elevated levels of oxidative-nitrosative stress, inflammatory mediators as well as apoptosis in neural cells significantly and dose dependently. The important finding of the study is that, the naringin-insulin combination not only attenuated the diabetic condition but also reversed the neuropathic pain, whereas insulin or naringin alone only improved hyperglycemia but partially reversed the pain response in diabetic rats. Thus, naringin is a potential flavonone bearing antioxidant, antiapoptotic and disease modifying property acting via modulation of endogenous biomarker to inhibit diabetes induced neuropathic pain. 相似文献
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