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1.
Silva DH Zhang Y Santos LA Bolzani VS Nair MG 《Journal of agricultural and food chemistry》2007,55(7):2569-2574
Plants from Iryanthera genus have been traditionally used as food supplements by South American Indians. The MeOH extract of leaves of Iryanthera juruensis, one of the plants endemic to the Amazon region and consumed in Brazil, and the hexane extract from its seeds inhibited lipid peroxidation (LPO) and cyclooxygenase (COX-1 and -2)) enzymes in in vitro assays. Further analyses of these extracts yielded 5-deoxyflavones (1-5) from the leaf extract and sargachromenol (6), sargaquinoic acid (7), a novel juruenolic acid (8), omega-arylalkanoic acids (9a-c), and the lignan guaiacin (10) from the seed extract. Compounds 3-5 inhibited LPO by 86%, 77%, and 88% at 10 ppm, respectively, and compounds 6 and 9a-c showed inhibition at 76% and 78% at 100 ppm, respectively. However, compounds 7 and 8 were inactive and lignan 10 exhibited LPO inhibitory activity by 99% at 100 ppm compared to commercial antioxidants butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and vitamin E. The flavones 1-5 also inhibited COX-1 and -2 enzymes by 50-65% at 100 ppm. Compound 6 showed high but nonselective inhibition of COX-1 and COX-2 enzymes, when compared to aspirin and Celebrex, a nonsteroidal anti-inflammatory drug (NSAID). Compounds 7 and 10 inhibited COX-1 by 60% and 65% and COX-2 by 37% and 18%, respectively, whereas compounds 8 and 9a-c showed little or no activity against these enzymes. 相似文献
2.
Victor JV Rossetto Lígia SLS da Mota Noeme S Rocha Hélio A Miot Fabrizio Grandi Cláudia VS Brand?o 《Acta veterinaria Scandinavica》2013,55(1):39
Background
Due to numerous complications associated to gastrointestinal augmented cystoplasty, this study aimed to analyze the anatomic repair of the bladder of 10 female dogs using grafts of porcine small intestinal submucosa (SIS) seeded with cultured homologous smooth muscle cells, and compare them with the acellular SIS grafts.Results
We assessed the possible side effects and complications of each type of graft by clinical examination, abdominal ultrasound and laboratory findings. Anatomic repair of neoformed bladder was assessed by histological staining for H/E and Masson''s Trichrome, analyzed with a Nikon Photomicroscope connected to the system of image analysis Image J.Conclusions
We propose that SIS associated to homologous smooth cells can improve the quality of tissue repair, and consequently decrease the potential complications inherent to acellular SIS. 相似文献3.
Expression and localization of angiopoietin family in corpus luteum during different stages of oestrous cycle and modulatory role of angiopoietins on steroidogenesis,angiogenesis and survivability of cultured buffalo luteal cells 
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下载免费PDF全文 SR Mishra MS Parmar VP Yadav R Reshma J Bharati MK Bharti A Paul VS Chouhan G Taru Sharma G Singh M Sarkar 《Reproduction in domestic animals》2016,51(6):855-869
The objective of this study was to document the expression and localization of angiopoietin (ANGPT) family members comprising of angiopoietin (ANGPT1 and ANGPT2), and their receptors (Tie1 and Tie2) in buffalo corpus luteum (CL) obtained from different stages of the oestrous cycle, and the modulatory role of ANGPT1 and ANGPT2 alone or in combinations on progesterone (P4) secretion and mRNA expression of phosphotidylinositide‐3kinase‐protein kinase B (PI3K‐AKT), phosphoinositide‐dependent kinase (PDK), protein kinase B (AKT), Bcl2 associated death promoter (BAD), caspase 3 and von willebrand factor (vWF) in luteal cells obtained from midluteal phase (MLP) of oestrous cycle in buffalo. Real‐time RT‐PCR (qPCR), Western blot and immunohistochemistry were applied to investigate mRNA expression, protein expression and localization of examined factors whereas, the P4 secretion was assessed by RIA. The mRNA and protein expression of ANGPT1 and Tie2 was maximum (p < .05) in mid luteal phase (MLP) of oestrous cycle. The ANGPT2 mRNA and protein expression was maximum (p < .05) in early luteal phase, decreased in MLP and again increased in late luteal phase of oestrous cycle. ANGPT family members were localized in luteal cells and endothelial cells with a stage specific immunoreactivity. P4 secretion was highest (p < .05) with 100 ng/ml at 72 hr when luteal cells were treated with either protein alone. The mRNA expression of PDK, AKT and vWF was highest (p < .05) and BAD along with caspase 3 were lowest (p < .05) at 100 ng/ml at 72 hr of incubation period, when cultured luteal cells were treated with either protein alone or in combination. To conclude, our study explores the steroidogenic potential of angiopoietins to promote P4 secretion, luteal cell survival and angiogenesis through an autocrine and paracrine actions in buffalo CL. 相似文献
4.
Soybean seed coat chitinase as a defense protein against the stored product pest Callosobruchus maculatus 下载免费PDF全文
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L Bonizzi M Amadori M Melegari W Ponti A Ceccarelli E Bolzani 《Zentralblatt für Veterin?rmedizin. Reihe B. Journal of veterinary medicine. Series B》1989,36(5):365-373
The concentrations of serum protein and immunoglobulin, complement, lysozyme, serum bactericidal activity and blast transformation of peripheral blood lymphocytes were assessed in dairy cattle in different herds and age groups. The study aimed at defining fundamental aspects of non-specific defence under the field conditions, related to age/season/management influences. The observed differences in the expression of these parameters are discussed, with regard to their role in the immune defence of calves and their relation to colostrum uptake. The possible use of these parameters in the control of animal welfare is stressed and the possibility is put forward of predicting possible unfavourable interactions with environmental pathogens. 相似文献
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Ronan A. Mullins MVB DECVS Carlos Sanchez Villamil DVM Laura E. Selmic BVetMed MPH DACVS-SA DECVS Michael S. Tivers BVSc PhD DECVS J. Brad Case DVM MS DACVS Ameet Singh BSc DVM DVSc DACVS Kelley M. Thieman Mankin DVM MS DACVS Davina M. Anderson MA VetMB PhD DSAS DECVS Robert N. White BSc BVetMed DSAS DECVS SFHEA Kathryn M. Pratschke MVB MVM DECVS Hilde de Rooster DVM MVM PhD DECVS Anne Kummeling DVM PhD DECVS Donald A. Yool BVMS PhD DECVS SFHEA Melanie Olive DVM Jean-Philippe Billet Dr vét DECVS Ines Gordo DVM MS Herve Brissot DV DECVS Cameron Broome BVSc DVCS FANZCVS Barbara M. Kirby DVM MS DACVS DECVS 《Veterinary surgery : VS》2020,49(5):958-970
8.
Gregory B. Daniel DVM MS Leslie Wantschek DVM Ronald Bright DVM MS Ilse Silva-Krott VS MS 《Veterinary radiology & ultrasound》1990,31(4):182-185
Radionuclide angiography was used to document occlusion of the distal aorta by thromboemboli in two dogs. Findings were confirmed by necropsy. The location of the thrombus corresponded with the scintigraphic lesion. Information obtained by the radionuclide angiogram was instrumental in patient management. We suggest the use of radionuclide angiography as a quick, non-invasive alternative to contrast angiography in animals suspected of having aortic thromboembolism. 相似文献
9.
Debonsi HM Miranda JE Murata AT de Bortoli SA Kato MJ Bolzani VS Furlan M 《Pest management science》2009,65(1):47-51
BACKGROUND: A dichloromethane‐methanol extract of the seeds of Piper tuberculatum Jacq. (Piperaceae) and two isobutyl amides, 4,5‐dihydropiperlonguminine (1) and pellitorine (2), which were isolated by chromatographic methods, were assayed for their lethality against the sugarcane borer Diatraea saccharalis F. (Lepidoptera: Pyralidae). RESULTS: Bioassays were carried out with fourth‐instar caterpillars through topical application of test solutions to the dorsal surface of the prothorax, and dose–response correlations were determined. Significant insect mortalities were observed 24, 48 and 72 h after treatment at concentrations of ≥ 100 µg insect?1. The LD50 and LD90 values for compound 1 were 92.83 and 176.50 µg insect?1, and for compound 2 they were 91.19 and 184.56 µg insect?1. CONCLUSION: According to the LD50 and LD90 for compounds 1 and 2, it can be inferred that the values reflect an acute lethal response to both compounds, based on interaction(s) of the toxicants with a primary target or series of targets. Thus, the amides were demonstrated to have potential value in the control of the sugarcane borer. Copyright © 2008 Society of Chemical Industry 相似文献
10.
Assessing the spatial distribution of Tuta absoluta (Lepidoptera: Gelechiidae) eggs in open‐field tomato cultivation through geostatistical analysis 下载免费PDF全文
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