Veterinary happiness     

Debbie L. Stoewen 《The Canadian veterinary journal. La revue veterinaire canadienne》2016,57(5):539-541

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Field evaluation of moxidectin/praziquantel oral gel in horses     

Grubbs ST  Amodie D  Rulli D  Wulster-Radcliffe M  Reinemeyer C  Yazwinski T  Tucker C  Hutchens D  Smith L  Patterson D 《Veterinary therapeutics : research in applied veterinary medicine》2003,4(3):249-256

The safety and efficacy of 2% moxidectin/12.5% praziquantel oral gel administered at a rate of 0.4 mg moxidectin and 2.5 mg praziquantel/kg was studied in client-owned horses under field use conditions. Four hundred horses (300 treated with moxidectin/praziquantel oral gel and 100 treated with vehicle) were enrolled, feces were collected, and eggs were counted. Investigators as well as horse owners were masked to treatment assignment. No adverse reactions to treatment were observed in any horses. Moxidectin/praziquantel gel reduced Anoplocephala spp by more than 99% and provided a significant (P <.05) reduction (> 98%) in the strongyle egg count of treated horses.  相似文献   

Common procedures and concerns with wildlife.     

Debbie A Myers 《Veterinary Clinics of North America: Exotic Animal Practice》2006,9(2):437-60, viii

Wildlife patients have special needs compared with pet patients in regard to handling and restraint, the importance of the stress response, physical examination, and neonatal concerns. Because many wildlife patients present with wounds and fractures, a good understanding of the pathophysiology of these processes is also important. The primary goal of all wildlife rehabilitation procedures is the ultimate release of the animal back into its natural environment.  相似文献   

Small Animal Behavioral Triage : A Guide for Practitioners     

Kenneth M. Martin  Debbie Martin  Julie K. Shaw 《Veterinary Clinics of North America: Small Animal Practice》2014

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Histamine-mediated delayed permeability response after scald burn inhibited by cimetidine or cold-water treatment   总被引：3，自引：0，他引：3  

J V Boykin  E Eriksson  M M Sholley  R N Pittman 《Science (New York, N.Y.)》1980,209(4458):815-817

Scald injury to one ear of the hairless mouse induced significant (P < .05) delayed edema formation in remote, uninjured skin. This remote edema formation was completely inhibited by immediate cold-water treatment of the scalded ear. Cold-water treatment significantly reduced histamine loss from the scalded ear, and the edema-inhibiting effect of the treatment could be mimicked by treating the animal prior to injury with the H2-histamine receptor antagonist cimetidine or a drug that causes histamine depletion. These observations suggest (i) that a histamine-mediated, delayed permeability response occurs after thermal injury that causes remote edema formation and (ii) that one mechanism of remote edema inhibition by cold-water treatment is the prevention of histamine release from thermally injured tissues.  相似文献   

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy     

Egan DF  Shackelford DB  Mihaylova MM  Gelino S  Kohnz RA  Mair W  Vasquez DS  Joshi A  Gwinn DM  Taylor R  Asara JM  Fitzpatrick J  Dillin A  Viollet B  Kundu M  Hansen M  Shaw RJ 《Science (New York, N.Y.)》2011,331(6016):456-461

Adenosine monophosphate-activated protein kinase (AMPK) is a conserved sensor of intracellular energy activated in response to low nutrient availability and environmental stress. In a screen for conserved substrates of AMPK, we identified ULK1 and ULK2, mammalian orthologs of the yeast protein kinase Atg1, which is required for autophagy. Genetic analysis of AMPK or ULK1 in mammalian liver and Caenorhabditis elegans revealed a requirement for these kinases in autophagy. In mammals, loss of AMPK or ULK1 resulted in aberrant accumulation of the autophagy adaptor p62 and defective mitophagy. Reconstitution of ULK1-deficient cells with a mutant ULK1 that cannot be phosphorylated by AMPK revealed that such phosphorylation is required for mitochondrial homeostasis and cell survival during starvation. These findings uncover a conserved biochemical mechanism coupling nutrient status with autophagy and cell survival.  相似文献   

Food, alcohol and cigarette availability and consumption in Almaty, Kazakstan: results and appraisal of a rapid assessment     

Yim A  Humphries D  Abuova G 《Public health nutrition》2003,6(8):791-800

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Vaccine-induced rabies in a pet skunk.     

J G Debbie 《Journal of the American Veterinary Medical Association》1979,175(4):376-377

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Mapping QTL for Fusarium wilt Race 2 partial resistance in pea (Pisum sativum)     

Kevin E. Mc Phee  Debbie A. Inglis  Babette Gundersen  Clarice J. Coyne 《Plant Breeding》2012,131(2):300-306

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The effects of F strain Mycoplasma gallisepticum, Mycoplasma synoviae, and the dual infection in commercial layer hens over a 44-week laying cycle when challenged before beginning of lay. II. Egg size distribution.     

S L Branton  B D Lott  J D May  W R Maslin  G T Pharr  J E Brown  D L Boykin 《Avian diseases》1999,43(2):326-330

In each of two trials, 160 commercial pullets were separated into four treatments with four replicates of 10 chickens in each treatment. Forty pullets were designated as controls and received no inoculation; 40 pullets received F strain Mycoplasma gallisepticum (FMG); an additional 40 pullets received Mycoplasma synoviae (MS); and the final 40 pullets were inoculated with both FMG and MS (dual). All inoculations occurred at 10 wk of age. Eggs from all treatments were collected daily, Monday-Thursday, and individually weighed. No significant difference was observed among the treatments for percentages of jumbo, extra-large, medium, small, peewee, or undergrade eggs. As a percentage of eggs laid for the 4 days of each week over the 44-wk laying cycle of each trial, the FMG hens laid significantly fewer large size eggs (43.2%) as compared with either controls (51.17%) or dual-infected hens (49.95%). No significant difference was found in percentage of large eggs laid by FMG hens when compared with MS hens.  相似文献