Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil     

Bose M  Hao X  Ju J  Husain A  Park S  Lambert JD  Yang CS 《Journal of agricultural and food chemistry》2007,55(19):7695-7700

The effect of a combination of (-)-epigallocatechin-3-gallate (EGCG) with fish oil on intestinal tumorigenesis in Apc (Min/+) mice fed a high-fat diet was investigated in the present study. The combined treatment of EGCG and fish oil for 9 weeks reduced the tumor number by 53% as compared to controls while neither agent alone had a significant effect. Apoptosis was significantly increased in all treatment groups. beta-Catenin nuclear positivity in adenomas from the combination group was lower than control mice, implicating the modulation of Wnt signaling by the combination. Fish oil and the combination significantly reduced prostaglandin E 2 (PGE 2) levels in small intestinal tumors as compared to controls, suggesting modulation of aberrant arachidonic acid metabolism by fish oil. Akt phosphorylation in adenomas was significantly reduced in all treatment groups, which may have contributed to the observed increase in apoptosis. The results indicate that a combination of low doses of EGCG and fish oil can inhibit tumor multiplicity in Apc (Min/+) mice.  相似文献   

Decolorization of Textile Effluent by Soluble Fenugreek (Trigonella foenum-graecum L) Seeds Peroxidase     

Qayyum Husain  Zoheb Karim  Zeeshan Zahoor Banday 《Water, air, and soil pollution》2010,212(1-4):319-328

Peroxidase from fenugreek (Trigonella foenum-graecum) seeds was highly effective in the decolorization of textile effluent. Effluent was recalcitrant to the action of fenugreek seeds peroxidase (FSP). However, in order to effectively decolorize effluent by peroxidase, the role of six redox mediators has been investigated. The maximum decolorization of textile effluent was observed in the presence of 1.0 mM 1-hydroxybenzotrizole, 0.7 mM H₂O₂, and 0.4 U ml^?1 of FSP in the buffer of pH 5.0 at 40°C in 2.5 h. The decolorization of textile effluent in a batch process by peroxidase was 85% in 5 h, whereas the complete decolorization of textile effluent by membrane-entrapped FSP was observed within 11 h of its operation. The absorption spectra of treated effluent exhibited a marked diminution in the absorbance at different wavelengths compared to untreated effluent.  相似文献   

Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding   总被引：1，自引：0，他引：1  

S P Wood  I J Tickle  A M Treharne  J E Pitts  Y Mascarenhas  J Y Li  J Husain  S Cooper  T L Blundell  V J Hruby 《Science (New York, N.Y.)》1986,232(4750):633-636

Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.  相似文献   

Age of a lunar anorthosite     

Husain L  Schaeffer OA  Sutter JF 《Science (New York, N.Y.)》1972,175(4020):428-430

The crystallization age of an Apollo 15 anorthosite rock, 15415,9, returned from the lunar highlands has been measured to be (4.09 +/- 0.19) x 10(9) years. The primitive lunar crust must have been formed in the first 300 to 400 x 10(6) years. The results give some credence to the hypothesis that the primitive lunar surface was molten and large-scale fractional crystallization occurred in the early history of the moon.  相似文献   

Dynamic shifts of limited working memory resources in human vision     

Bays PM  Husain M 《Science (New York, N.Y.)》2008,321(5890):851-854

Our ability to remember what we have seen is very limited. Most current views characterize this limit as a fixed number of items-only four objects-that can be held in visual working memory. We show that visual memory capacity is not fixed by the number of objects, but rather is a limited resource that is shared out dynamically between all items in the visual scene. This resource can be shifted flexibly between objects, with allocation biased by selective attention and toward targets of upcoming eye movements. The proportion of resources allocated to each item determines the precision with which it is remembered, a relation that we show is governed by a simple power law, allowing quantitative estimates of resource distribution in a scene.  相似文献   

Comment on "Detecting awareness in the vegetative state"     

Nachev P  Husain M 《Science (New York, N.Y.)》2007,315(5816):1221; author reply 1221

Owen et al. (Brevia, 8 September 2006, p. 1402) claimed that a patient's brain activity revealed that she was consciously responding to commands despite being in a vegetative state. However, several alternative explanations were not eliminated. Specifically, the activity could reflect unconscious reactions to the last word in the command, not conscious decisions to respond. A refined experimental design could clarify these issues.  相似文献   

Proton magnetic resonance spectroscopic method for determination of phenylbutazone and oxyphenbutazone in tablets     

S Husain  M Kifayatullah  R N Rao 《Journal of the Association of Official Analytical Chemists》1988,71(3):525-527

A simple, specific, and rapid 1H nuclear magnetic resonance spectroscopic method for the assay of phenylbutazone and oxyphenbutazone is described. Spectra are recorded in CDCI3 containing 1,3-dichloro-5-nitrobenzene as an internal standard. The aromatic proton resonances for the standard, at delta 7.7 and 8.2, are well separated from those of phenylbutazone and oxyphenbutazone, which are in the region of delta 6.5-7.3 ppm. Average percent recoveries of phenylbutazone and oxyphenbutazone were 98.9 and 98.6 with standard deviations of 0.6 and 0.7, respectively. Commercial formulations were analyzed and the results obtained by the proposed method closely agreed with those found by the British Pharmacopoeia method.  相似文献   

Screening new <Emphasis Type="Italic">Arachis</Emphasis> amphidiploids,and autotetraploids for resistance to late leaf spot by detached leaf technique     

Nalini Mallikarjuna  Deepak R. Jadhav  Kanaka Reddy  Fatema Husain  Kumkum Das 《European journal of plant pathology / European Foundation for Plant Pathology》2012,132(1):17-21

Cultivated groundnut is susceptible to late leaf spot (LLS) caused by Phaeoisariopsis personata [(Berk. & M.A. Curtis) Aex] and resistance is low to moderate in the primary gene pool of groundnut. Closely related wild species in the secondary gene pool are highly resistant to the disease. All the closely related Arachis species are diploid and cultivated groundnut is a tetraploid. Utilization of diploid Arachis species to transfer LLS resistance is time consuming and cumbersome. New sources of Arachis hypogaea (also called synthetic groundnut) were developed at ICRISAT. These are tetraploids and the present investigation has shown that they are resistant to LLS.  相似文献   

Comparative Efficacy of CO2 and Ozone Gases Against Ephestia cautella (Lepidoptera: Pyralidae) Larvae Under Different Temperature Regimes     

M. Husain  Khawaja G. Rasool  Muhammad Tufail  Abdullah M. A. Alhamdan  Khalid Mehmood  Abdulrahman S. Aldawood 《Journal of insect science (Online)》2015,15(1)

Comparative efficacy of three different modified atmospheres: 100% CO₂, 75% CO₂ + 25% N₂, and 22 ppm ozone were examined against larval mortality of the almond moth, Ephestia cautella (Walker) (Lepidoptera: Pyralidae) at temperature regimes of 25°C and 35 ± 2°C and 60 ± 5% relative humidity, and 9:15 dark and light. Wandering young larval instars, which are fast growing, large enough in size and considered as more tolerant to modified atmosphere, were collected directly from the rearing culture, placed inside pitted date fruits of vars.: “Khudri,” “Ruziz,” and “Saqie,” were treated with aforementioned gases for 24, 48, and 72 h. The immediate and delayed larval mortality was recorded after each exposure timing. Ozone possessed the strongest fumigant toxicity causing 100% mortality with all varieties, at 25 and 35°C after 24 h exposure and was more effective than 75% CO₂ that caused 83 and 100% immediate mortality with variety ruziz at 25 and 35°C, respectively. Extending the treatments exposure time to 72 h, 100% mortality was recorded by exposing larvae to any of the studied gases at 25 and 35°C. These results suggest that gases and temperature used in this study can be effectively used to control E. cautella in dates and stored grains.  相似文献   

Effect of rootstocks on the leaf mineral content of citrus     

Husain S. Ahmed  Mohamed Y. Al-Shurafa 《Scientia Horticulturae》1984,23(2):163-168

Leaves from ‘Valencia’, ‘Hamlin’ and ‘Washington Navel’ oranges grown on ‘Rangpur’ lime, ‘Cleopatra’ mandarin, ‘Sour Orange’, ‘Troyer’ citrange and ‘Rough Lemon’ root-stocks were analzed for N, P, K, Ca, Na, Cl, Fe, Mn, Cu and Zn. Significant differences among rootstocks were obtained for K, Ca, $\text{Ca}\text{K}$, Na and Cl, but not for N, P, Fe, Mn, Zn and Cu. Scion leaves on ‘Cleopatra’ mandarin tended to be low in K and high in $\text{Ca}\text{K}$ and those on ‘Rangpur’ lime were high in K and low in Ca and $\text{Ca}\text{K}$. ‘Troyer’ citrange induced higher uptake of Na and Cl than all other rootstocks. ‘Washington Navel’ leaves contained more Fe, Zn, Cu and Mn, and less Na, than ‘Hamlin’ or ‘Valencia’ leaves. ‘Valencia’ leaves contained more Ca and less K than the other two cultivars. The nutritional status of the trees was slightly low in N, K and Mn, optimum in Fe, Zn and Cu, normal-to-high in P, and contained non-toxic levels of Na and Cl. The statistical interaction of root stock and scion was found non-significant.  相似文献