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Speckle‐Tracking Echocardiography in Dogs With Patent Ductus Arteriosus: Effect of Percutaneous Closure on Cardiac Mechanics 
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Echocardiographic Assessment of Cardiac Function by Conventional and Speckle‐Tracking Echocardiography in Dogs with Patent Ductus Arteriosus 下载免费PDF全文
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Locatelli C. Caronte I. Scaccabarozzi L. Migliavacca R. Pagani L. Moroni P. 《Veterinary research communications》2009,33(1):141-144
Veterinary Research Communications - 相似文献
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The influence of stresses due to transport of beef cattle and their allotment to feedlots on trichostrongylid infection was studied. The greatest increases in worm egg counts and serum pepsinogen levels were seen at 5 h and 30 days after allotment. These apparently resulted from reactivation of arrested larvae which the animals ingested while grazing during late autumn at the breeding farm. 相似文献
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Population pharmacokinetics of methadone hydrochloride after a single intramuscular administration in adult Japanese sika deer (Cervus nippon nippon) 下载免费PDF全文
下载免费PDF全文 Christopher Scala Amélie Marsot Marie‐Josée Limoges Yann Locatelli Nicolas Simon Jean‐Claude Alvarez 《Veterinary anaesthesia and analgesia》2015,42(2):165-172
ObjectiveTo assess the population pharmacokinetics of methadone in deer.Study designProspective non-randomized experimental trial.AnimalsTwelve healthy adult sika deer (nine males and three females).MethodsDeer received intramuscular administration of racemic methadone hydrochloride at 0.5 mg kg−1 or 1 mg kg−1. Plasma methadone and its metabolite 2-Ethylidene-1,5-Dimethyl-3,3-Diphenyl-Pyrolidine (EDDP) concentrations were determined by validated liquid chromatography coupled to tandem mass spectrometry methods, at times 0, 30 minutes, 1, 2, 3, 4, 5, 6, 8, 12 and 24 hours. Population pharmacokinetics analysis was undertaken using a non-linear mixed effects modelling (NONMEM).ResultsA two-compartment linear disposition model best described observed time-concentration profiles of methadone and EDDP. Population parameter estimates of methadone were elimination clearance (17.3 L hour−1), metabolic clearance (34.6 L hour−1), volume of distribution of compartment 1 (216.0 L) and volume of distribution of compartment 2 (384.0 L). Population parameter estimates of EDDP were elimination clearance (121.0 L hour−1), volume of distribution of compartment 3 (1.08 L) and volume of distribution of compartment 4 (499.5 L). The total clearance and total volume of distribution of methadone and EDDP were 51.9 L hour−1, 121.0 L hour −1, 600.0 L and 500.6 L, respectively. The methadone terminal elimination half-life was 8.19 hours. No adverse effects were observed after methadone administration.Conclusions and Clinical relevanceFollowing intramuscular injection, methadone was characterized by a large total volume of distribution, high systemic clearance and intermediate terminal half-life in sika deer. 相似文献
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Giuliano Pisoni Patrizia D’Amelio Francesca Sassi Giovanni Manarolla Licia Scaccabarozzi Clara Locatelli Nausicaa Mazzocchi Mirko Baruscotti Dario DiFrancesco Paolo Moroni 《Veterinary journal (London, England : 1997)》2011,189(3):361-363
Formation of multinucleated giant cells (MGCs) by macrophage fusion is a typical cytopathic effect of lentiviral replication in caprine monocytes and MGC formation from cultured caprine peripheral blood mononuclear cells (PBMCs) has been considered to be diagnostic for small ruminant lentivirus (SRLV) infection. In this study, formation of MGCs was observed after 7–14 days when PBMCs were cultured from healthy goats free from SRLV infection. These MGCs expressed tartrate-resistant acid phosphatase, calcitonin receptor, integrin αVβ3, cathepsin K and matrix metalloproteinase 9 and were able to resorb bone in vitro in the absence of RANKL and macrophage colony stimulating factor, consistent with an osteoclast phenotype. 相似文献
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