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Alireza Shirpoor Leila Norouzi Samira Nemati Mohammad Hasan Khadem Ansari 《Iranian Biomedical Journal》2015,19(2):117-123
Background:
Hyperlipidemia and oxidized-low-density lipoproteins (Ox-LDL) are important independent cardiovascular risk factors that have been shown to stimulate vascular smooth muscle cell (VSMC) proliferation. The purpose of the present study was to investigate the effect of vitamin E on Ox-LDL, lipid profile, C-reactive protein (CRP), and VSMC proliferation of rat aorta.Methods:
Male Wistar rats (n = 32) were divided into four groups namely: sham (SH), control (C), non-treated diabetic, and vitamin E-treated diabetic (VETD) groups. Ox-LDL, lipid profile, CRP and VSMC proliferation of aorta were measured after 42 days.Results:
The results revealed that along with a significant increase in VSMC proliferation, the amount of CRP, Ox-LDL, and lipid profiles in diabetic rats. VSMC proliferation was significantly ameliorated, and elevated CRP, Ox-LDL, and lipid profiles were also restored to those of shams in VETD.Conclusions:
These findings strongly support the idea that diabetes induces Ox-LDL-mediated oxidative stress and VSMC proliferation in aorta of rat and imply that vitamin E has a strong protective effect as an antioxidant. Key Words: Ox-LDL, Vitamin E, Diabetes, VSMC proliferation 相似文献2.
Teresa M. M. dos Santos Humberto Nóbrega José Filipe Teixeira Ganan?a Emanuel Silva Desire Afonso Abílio F. M. Gutiérres Jan J. Slaski Manhaz Khadem Miguel ?. A. Pinheiro de Carvalho 《Genetic Resources and Crop Evolution》2012,59(7):1377-1388
The genetic variability of high molecular weight glutenin subunits (HMWGS) composition at the Glu-1 loci in bread wheat (Triticum aestivum L.) was studied electrophoretically using the SDS–PAGE in 3,470 individuals representing 159 populations originated from the Canary Islands (Spain), the Archipelago of Madeira (Portugal) and the continental Portugal. A total of 25 alleles were detected, resulting in 69 different allele combinations. The geographical distribution of the high molecular weight glutenin alleles confirms historical data regarding circulation of wheat germplasm between the Iberian Peninsula and Madeira and between Madeira and the Canary Islands and vice versa. 相似文献
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Effectiveness of chopped lucerne hay as a moisture absorbent for low dry‐matter maize silage: Effluent reduction,fermentation quality and intake by sheep 
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下载免费PDF全文 This study determined effects of addition of lucerne hay (LH) as moisture absorbent on effluent reduction, fermentation and subsequent intake of maize (corn) silage by sheep. Treatments included maize forage ensiled without LH (LH0), with 50 g/kg LH (LH5) and with 100 g/kg LH (LH10) on a fresh weight basis. Silages were made in 150‐kg bags in triplicate. Upon opening, representative samples from each bag were taken twice weekly during a feeding trial and used for laboratory analyses in a completely randomized design. Silages were fed ad libitum to six ewes in a duplicated 3 × 3 Latin square design with 21‐day periods for intake and digestibility determination. Lucerne hay incorporation linearly increased DM, ash, water‐soluble carbohydrates, buffering capacity and pH of silages, while it linearly decreased ammonia nitrogen, acetic acid and ethanol concentrations (p < .05). Effluent volume linearly decreased from 33 ml/kg in LH0 to 0.8 ml/kg in LH10. Addition of LH resulted in a linear increase in intakes of organic matter and fibre in ewes, while digestibilities of these nutrients linearly decreased (p < .05). Lucerne hay addition improved fermentation parameters and resulted in increased intake of maize silage without having negative impact on aerobic stability. 相似文献
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