Water-formed structures: geomorphology and hydrology of karst terrains     

Bloom AL 《Science (New York, N.Y.)》1989,243(4898):1618-1619

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Quaternary geology: the pleistocene     

Bloom AL 《Science (New York, N.Y.)》1984,225(4659):307-308

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Long-term storage of information in DNA   总被引：1，自引：0，他引：1  

Bancroft C  Bowler T  Bloom B  Clelland CT 《Science (New York, N.Y.)》2001,293(5536):1763-1765

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Effect of a valine residue at codon 352 of the VP2 capsid protein on in vivo replication and pathogenesis of Aleutian disease parvovirus in mink   总被引：4，自引：0，他引：4  

Stevenson MA  Fox JM  Wolfinbarger JB  Bloom ME 《American journal of veterinary research》2001,62(10):1658-1663

OBJECTIVE: To determine whether a group of 3 genetic differences in the nonstructural protein (NS1) or 1 genetic difference in the structural protein (VP2) of Aleutian disease parvovirus (ADV) is responsible for an increase in the in vivo replication and pathogenicity of G/U-8, a chimera of ADV-G (nonpathogenic) and ADV-Utah (pathogenic), compared with G/U-10. ANIMALS: 32 eight-month-old female sapphire mink (Mustela vison). PROCEDURE: Chimeric viruses were constructed, propagated in vitro, and used to inoculate mink. Antiviral antibody responses, presence of serum viral nucleic acid, and serum gamma globulin concentrations were monitored for 120 days following inoculation. Histologic examination of the liver, kidneys, spleen, and mesenteric lymph nodes was performed after necropsy. RESULTS: A chimera containing only the 3 amino acid substitutions in NS1 did not elicit measurable responses indicative of replication or pathogenicity in inoculated mink. Serum antiviral antibody responses, frequency of detection of viral nucleic acid in serum, gamma globulin response, and histologic changes in mink inoculated with chimeras containing a valine residue at codon 352 (352V) of VP2 capsid were increased, compared with values from mink inoculated with chimeric viruses that did not contain 352V. CONCLUSIONS AND CLINICAL RELEVANCE: A valine residue at codon 352 in the VP2 capsid protein of ADV affects in vivo viral replication and pathogenicity. This amino acid may be part of an incompletely defined pathogenic determinant of ADV. Further characterization of the pathogenic determinant may allow future development of focused preventive and therapeutic interventions for Aleutian disease of mink.  相似文献   

Postanaesthetic recumbency in a Belgian filly with polysaccharide storage myopathy     

Bloom BA  Valentine BA  Gleed RD  Cable CS 《The Veterinary record》1999,144(3):73-75

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Rice, races, and riches     

Bloom F 《Science (New York, N.Y.)》2000,288(5468):973

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Too much of a good thing?     

Bloom FE 《Science (New York, N.Y.)》2000,287(5460):1925

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Canine and feline eosinophilic skin diseases.     

Paul B Bloom 《Veterinary Clinics of North America: Small Animal Practice》2006,36(1):141-60, vii

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Plasma enteroglucagon and neurotensin levels in gnotobiotic calves infected with enteropathogenic and non-enteropathogenic viruses   总被引：1，自引：0，他引：1  

G A Hall  K R Parsons  J C Bridger  M A Ghatei  Y C Ying  S R Bloom 《Research in veterinary science》1985,38(1):99-103

Five gnotobiotic calves were each infected with five viruses. Each calf was inoculated with coronavirus at seven days old, followed by astrovirus, Newbury agent, parainfluenzavirus type 3 and rotavirus at intervals of two weeks. Three of the viruses were enteropathogenic (bovine coronavirus, bovine calici-like virus and bovine rotavirus) and two were not (bovine astrovirus and parainfluenzavirus type 3). Plasma levels of the peptide hormones enteroglucagon and neurotensin and faecal output were measured daily and xylose absorption was studied before and after each infection. A close correlation was found between a rise in plasma enteroglucagon and neurotensin and infection with enteropathogenic viruses. The three enteropathogenic viruses caused increased daily faecal output, and elevated plasma levels of enteroglucagon and neurotensin, while the non-enteropathogens did not. The calici-like virus and rotavirus but not the coronavirus caused xylose malabsorption.  相似文献   

Gold-induced immune thrombocytopenia in the dog   总被引：1，自引：0，他引：1  

J C Bloom  S A Blackmer  P J Bugelski  J M Sowinski  L Z Saunders 《Veterinary pathology》1985,22(5):492-499

In two seven-year studies with gold compounds in dogs of both sexes, thrombocytopenia was observed after 45 to 72 months of dosing in three of 14 and two of 14 dogs in high-dose groups that received 2.4 to 3.6 mg/kg of auranofin per day orally or 0.5 to 2.0 mg/kg of gold sodium thiomalate intramuscularly once every three days, respectively. An immune basis for the disorder was suggested by the apparent consumptive nature of the thrombocytopenia (increased bone marrow megakaryocytes and large peripheral blood platelets), the response to corticosteroid therapy and the demonstration of increased platelet-associated immunoglobulin. The latter was demonstrated with a solid phase radioimmunoassay and by electron microscopy using a staphylococcal protein A-colloidal gold conjugate. Platelet-associated immunoglobulin decreased as the platelet counts rose, and in one dog monitored over periods of steroid-induced remissions and subsequent relapses, the amount of platelet-associated immunoglobulin G correlated inversely with the platelet count (r = 0.82). These findings suggest that the long-term administration of gold compounds in dogs is associated with a dose-dependent incidence of thrombocytopenia, which is immune-mediated and similar to that associated with parenteral chrysotherapy in man. The application of tests for platelet-associated immunoglobulin to canine patients with immune thrombocytopenia should be useful in the diagnosis of the disorder in clinical practice.  相似文献