Ovine hereditary chondrodysplasia (spider syndrome) in Suffolk lambs   总被引：1，自引：0，他引：1  

PH PHILLIPS  CM BUNN  CE ANDERSON 《Australian veterinary journal》1993,70(2):73-74

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Acupuncture and traditional Chinese veterinary medicine for treatment of a mare with rectal paralysis          下载免费PDF全文

M. M. Sleeper  K. Fishman  R. J. MacKay  M. Brown  A. G. Bauck  H. Xie 《Equine Veterinary Education》2018,30(9):460-463

An 8‐year‐old Appaloosa mare with rectal paralysis due to a cosmetic ethanol ‘tail block’ was treated with traditional Chinese veterinary medicine treatments including acupuncture and herbal medicine. Her rectal and tail tone gradually improved after the treatment. At 4 months after initial presentation, the mare was able to produce faecal piles on a regular basis, and manual evacuations were no longer needed. Significant improvement was within 30 days of beginning treatment. At 8 months, the owner indicated that the mare had normal defaecation, was able to swish the tail from side to side and lift the tail to urinate, and had no evidence of straining to defaecate or colic.  相似文献   

Equine Cryptorchidism: Pre-surgical Considerations and Surgical Management     

J. N. MOORE D.V.M.    J. H. JOHNSON D.V.M.  M.S.  L G. TRITSCHLER D.V.M.  M.S.  H. E. GARNER D.V.M.  PH.D. 《Veterinary surgery : VS》1978,7(2):43-47

Horses with undescended testes are frequently presented to the veterinary surgeon for castration. The pertinent pre-operative evaluations and diagnostic procedures that should be made prior to either surgical intervention or referral of such cases are outlined. Several accepted anesthetic and surgical techniques are similarly reviewed. Case histories of 58 horses referred during a two year period are reviewed and correlated with the findings of a recent study of equine testicular development and descent.  相似文献   

Nodules caused by demodex-like mites in the skin of tiger quolls (Dasyurus maculatus)     

PH HOLZ 《Australian veterinary journal》1998,76(1):59-60

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A Simplified Method of Preparing Active Extracts of B-Glucuronidase     

Fishman WH  Talalay P 《Science (New York, N.Y.)》1947,105(2718):131-132

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Enzymatic modification of pectin to increase its calcium sensitivity while preserving its molecular weight     

Hotchkiss AT  Savary BJ  Cameron RG  Chau HK  Brouillette J  Luzio GA  Fishman ML 《Journal of agricultural and food chemistry》2002,50(10):2931-2937

A commercial high-methoxy citrus pectin was treated with a purified salt-independent pectin methylesterase (PME) isozyme isolated from Valencia orange peel to prepare a series of deesterified pectins. A series of alkali-deesterified pectins was also prepared at pH 10 under conditions permitting beta-elimination. Analysis of these pectins using high-performance size exclusion chromatography (HPSEC) with on-line multiangle laser light-scattering, differential viscometer, and refractive index (RI) detectors revealed no reduction in weight-average molecular weight (M(w); 150000) in the PME-treated pectin series, whereas a 16% reduction in intrinsic viscosity (IV) occurred below a degree of esterification (DE) of 47%. In contrast, alkali deesterification rapidly reduced both M(w) and IV to less than half of that observed for untreated pectin. PME treatment of a non-calcium-sensitive citrus pectin introduced calcium sensitivity with only a 6% reduction in the DE. Triad blocks of unesterified galacturonic acid were observed in (1)H nuclear magnetic resonance spectra of this calcium-sensitive pectin (CSP). These results demonstrate that the orange salt-independent PME isozyme utilizes a blockwise mode of action. This is the first report of the preparation of a CSP by PME treatment without significant loss of the pectin's M(w) due to depolymerization.  相似文献   

Discovery of intense gamma-ray flashes of atmospheric origin   总被引：1，自引：0，他引：1  

Fishman GJ  Bhat PN  Mallozzi R  Horack JM  Koshut T  Kouveliotou C  Pendleton GN  Meegan CA  Wilson RB  Paciesas WS  Goodman SJ  Christian HJ 《Science (New York, N.Y.)》1994,264(5163):1313-1316

Detectors aboard the Compton Gamma Ray Observatory have observed an unexplained terrestrial phenomenon: brief, intense flashes of gamma rays. These flashes must originate in the atmosphere at altitudes above at least 30 kilometers in order to escape atmospheric absorption and reach the orbiting detectors. At least a dozen such events have been detected over the past 2 years. The photon spectra from the events are very hard (peaking in the high-energy portion of the spectrum) and are consistent with bremsstrahlung emission from energetic (million-electron volt) electrons. The most likely origin of these high-energy electrons, although speculative at this time, is a rare type of high-altitude electrical discharge above thunderstorm regions.  相似文献   

Cloning of complementary DNA for GAP-43, a neuronal growth-related protein   总被引：33，自引：0，他引：33  

L R Karns  S C Ng  J A Freeman  M C Fishman 《Science (New York, N.Y.)》1987,236(4801):597-600

GAP-43 is one of a small subset of cellular proteins selectively transported by a neuron to its terminals. Its enrichment in growth cones and its increased levels in developing or regenerating neurons suggest that it has an important role in neurite growth. A complementary DNA (cDNA) that encodes rat GAP-43 has been isolated to study its structural characteristics and regulation. The predicted molecular size is 24 kilodaltons, although its migration in SDS-polyacrylamide gels is anomalously retarded. Expression of GAP-43 is limited to the nervous system, where its levels are highest during periods of neurite outgrowth. Nerve growth factor or adenosine 3',5'-monophosphate induction of neurites from PC12 cells is accompanied by increased GAP-43 expression. GAP-43 RNA is easily detectable, although at diminished levels, in the adult rat nervous system. This regulation of GAP-43 is concordant with a role in growth-related processes of the neuron, processes that may continue in the mature animal.  相似文献   

Renin and angiotensin: the complete system within the neuroblastoma x glioma cell   总被引：6，自引：0，他引：6  

M C Fishman  E A Zimmerman  E E Slater 《Science (New York, N.Y.)》1981,214(4523):921-923

Cells of the homogeneous hybrid line neuroblastoma x glioma (NG108-15) have many neuronal properties. Immunocytochemical tests show that they contain both immunoreactive renin and angiotensin; direct radioimmunoassays show that they are positive for renin, angiotensin I, and angiotensin II; enzymatic assays show that they contain angiotensinogen and converting enzyme as well. The renin appears to be present in an enzymatically inactive form that can be activated by trypsin and then blocked by antiserum to purified mouse submaxillary renin. Renin concentration and activity are increased by enhancing cellular differentiation with dibutyryl cyclic adenosine monophosphate or by serum withdrawal. These findings demonstrate a complete renin-angiotensin system within these neuron-like cells, and suggest that activation of intracellular renin could generate angiotensin II.  相似文献   

Axonal proteins of presynaptic neurons during synaptogenesis   总被引：5，自引：0，他引：5  

P Sonderegger  M C Fishman  M Bokoum  H C Bauer  P G Nelson 《Science (New York, N.Y.)》1983,221(4617):1294-1297

Changes occur in the synthesis and axonal transport of neuronal proteins in dorsal-root ganglia axons as a result of contact with cells from the spinal cord during synapse formation. Dorsal-root ganglia cells were cultured in a compartmental cel culture system that allows separate access to neuronal cell bodies and their axons. When cells from the ventral spinal cord were cultured with the dorsal-root ganglia axons, synapses were established within a few days. Metabolic labeling and two-dimensional electrophoresis revealed that four of more than 300 axonal proteins had changed in their expression by the time synapses were established. The highly selective nature of these changes suggests that the proteins involved may be important in the processes of axon growth and synapse formation and their regulation by the regional environment.  相似文献