Administration of research     

Gross PR 《Science (New York, N.Y.)》1986,232(4754):1078

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The dioxin issue     

Gross ML 《Science (New York, N.Y.)》1979,206(4416):327-328

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Brain Circuits and Functions of the Mind. Essays in Honor of Roger W. Sperry. Colwyn Trevarthen, Ed. Cambridge University Press, New York, 1990. xxxviii, 410 pp., illus. $69.50; paper, $37.50     

Gross CG 《Science (New York, N.Y.)》1990,249(4973):1175-1176

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ISVD-3 Characterization of cutaneous angiomatosis in dogs and cats     

V. K. Affolter  T. L. Gross  E. J. Walder 《Veterinary dermatology》2004,15(S1):71-71

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FC‐14
Clonality studies of feline cutaneous lymphocytosis     

S. Gilbert  V. K. Affolter  P. Schmidt  S. Kosten  P. M. Kramme  T. L. Gross  P. Ihrke  P. F. Moore 《Veterinary dermatology》2004,15(Z1):24-24

A previous study described cutaneous lymphocytosis (CL) in 23 cats. The process resembles cutaneous pseudolymphoma in humans, a heterogeneous group of benign reactive proliferations of well‐differentiated lymphocytes in the skin of humans. Morphological and immunophenotypic characteristics do not offer reliable criteria to accurately predict the clinical outcome of feline CL or pseudolymphoma in humans. Presence of clonal cell populations is more consistent with a neoplastic process. In a previous study, feline CL lesions (20 cats) were evaluated for clonality using PCR, and only two cats had monoclonal T‐cell populations. Because false‐negative results may occur, the purpose of this study was to repeat the PCR using a revised primer set based on analysis of additional feline T‐cell receptor γ (TCRγ) sequences. DNA was isolated from 29 skin lesions and six internal organs of 20 cats. DNA integrity was assessed by glyceraldehyde‐3‐phosphate dehydrogenase PCR. Polymerase chain reaction clonality was performed using the revised primer set specific for feline TCRγ, and duplicate samples were evaluated. The PCR products were assessed by heteroduplex analysis. Clonal rearrangement of TCRγ was detected in 14 cats (24 of 35 tissues: 21 of 29 skin lesions and three of six internal organs); eight of these cats are still alive and six were euthanized. Monoclonal populations were seen in three of five cats that had involvement of internal organs. These findings indicate that feline CL is best considered as a slowly progressive process which may be reactive, but often evolves into a low‐grade indolent lymphoma. Funding: George H. Muller Fund for Research in Dermatology.  相似文献   

Hyperglycaemia in transition dairy cows: Effects of lactational stage and conjugated linoleic acid supplementation on glucose metabolism and turnover          下载免费PDF全文

L. Grossen‐Rösti  E. C. Kessler  A. Tröscher  R. M. Bruckmaier  J. J. Gross 《Journal of animal physiology and animal nutrition》2018,102(2):483-494

Supplementing conjugated linoleic acid ( CLA ) is supposed to spare glucose due to the milk fat‐depressing effect of the trans ‐10, cis ‐12 CLA isomer, and allows repartitioning nutrients despite an energy deficiency in early lactation. However, there is still a lack of knowledge in terms of the dynamic pattern of the glucose turnover in transition dairy cows. We hypothesized that dairy cows supplemented with CLA have an altered rate of glucose turnover and insulin sensitivity during early lactation. We conducted three consecutive hyperglycaemic clamps (HGC ) in weeks ?2, +2 and +4 relative to parturition in Holstein cows supplemented daily either with 70 g of lipid‐encapsulated CLA (6.8 g trans ‐10, cis ‐12 and 6.6 g of the cis ‐9, trans ‐11 CLA isomer; CLA ; n  = 11) or with 56 g of control fat ( CON ; n  = 11). From week ?3 up to week +4 relative to parturition, milk yield and dry matter intake (DMI ) were recorded daily, while body weight (BW ) and milk composition were obtained once weekly. Blood samples were taken once weekly and every 30 min during the HGC . Plasma was analysed for concentrations of glucose, fatty acids (FFA ), beta‐hydroxybutyrate (BHB ), insulin, triglycerides and cholesterol. The CLA supplementation did not affect performance and metabolic parameters except for BHB and cholesterol. Furthermore, insulin concentrations and insulin sensitivity were affected by treatment. During the HGC in early lactation, insulin response was lower and decrease in FFA and BHB greater compared with the HGC in week ?2 although glucose target concentration achieved during the steady‐state period was similar for all three HGC . Our findings in terms of insulin and cholesterol suggest that body reserves are preserved through CLA feeding without restraining animal's performance. Furthermore, CLA effects on cholesterol and triglyceride concentrations indicated beneficial effects on hepatic lipid export contributing to an improved efficiency of prevailing metabolites in circulation.  相似文献   

Organic zinc and copper supplementation on antioxidant protective mechanism and their correlation with sperm functional characteristics in goats          下载免费PDF全文

M Narasimhaiah  A Arunachalam  S Sellappan  VK Mayasula  PR Guvvala  SK Ghosh  V Chandra  J Ghosh  H Kumar 《Reproduction in domestic animals》2018,53(3):644-654

Trace minerals feeding had significant effects on sperm production and fertility with better absorption and proper utilization within the body for optimum reproductive function. Several studies have shown that more influenced trace elements in the diets of animals are copper (Cu) and zinc (Zn). Bucks showing deficiency of this mineral might affect the quality of semen production which in turn would affect the fertility. This experiment was thus designed to test the effects of organic Cu and Zn supplementation on antioxidants enzyme activities and sperm functional attributes in fresh semen of bucks. Forty bucks (n = 40, Aged 5 months) were assigned to ten groups of four animals in each group, supplemented (for a period of 8 months) with different levels of organic Zn: 20 mg (T2), 40 mg (T3) and 60 mg (T4), organic Cu: 12.5 mg (T5), 25 mg (T6), 37.5 mg (T7) and combined organic Zn and Cu: 20 + 12.5 mg (T8), 40 + 25 mg (T9), 60 + 37.5 mg (T10), respectively, per kg dry matter and no additional mineral diet (control; T1). One hundred and sixty semen samples were collected through electro‐ejaculator and analysed for sperm quantity, quality, acrosome intactness and plasma membrane integrity and correlated with the catalase, superoxide dismutase, glutathione peroxidase and glutathione reductase enzyme activities in seminal plasma. The results indicated organic Cu and zinc supplemented bucks produced more sperm cells, had higher sperm concentrations, maintained higher (p < .01) sperm livability, plasma membrane and acrosome integrities, more motility and velocity. The increased antioxidant enzyme activities, reduced oxidative stress and lowered lipid peroxidation were positively correlated (p < .05) with the sperm functional attributes. In conclusion, organic Cu and Zn supplement to male goats showed protective roles against oxidative damage and maintained better fresh semen characteristics.  相似文献   

Production of salmonid amoebic gill disease by exposure to Paramoeba sp. harvested from the gills of infected fish     

D Zilberg  A Gross  & B L Munday 《Journal of fish diseases》2001,24(2):79-82

Atlantic salmon, S almo salar L., were exposed to different concentrations of Paramoeba sp. The lowest concentration which induced amoebic gill disease (AGD) was 230 Paramoeba sp. L^–1 and the severity of infection increased with increasing concentration. The concentration of Paramoeba sp. positively correlated with the number of gill lesions ( R ² > 0.7). This study provides evidence that Paramoeba sp. is the causative agent of AGD and describes an experimental model that enables the severity of the induced disease to be controlled.  相似文献   

Genetic diversity and differentiation of sea trout (<Emphasis Type="Italic">Salmo trutta</Emphasis>) populations in Lithuanian rivers assessed by microsatellite DNA variation     

Aurelija Samuiloviene  Antanas Kontautas  Riho Gross 《Fish physiology and biochemistry》2009,35(4):649-659

The genetic diversity and differentiation of sea trout were studied in three river basins in Lithuania: Akmena-Dane, Bartuva, and Nemunas. A total of 282 individuals were genotyped at eight microsatellite loci. A similar level of genetic diversity was found in all of the populations studied: mean allelic richness ranged from 3.64 to 5.03, and average expected heterozygosity ranged from 0.588 to 0.721. Significant genetic divergence was observed among the different river basins as well as between populations within the drainages. All pairwise F _ST values were highly significant, ranging from 0.027 to 0.197. The analysis of molecular variance showed rather weak hierarchical population structuring within the Nemunas basin, which may be explained by extensive gene flow among different river basins or, alternatively, reflect the influence of artificial breeding. Information on genetic diversity and differentiation of the Lithuanian sea trout populations will be useful for future management decisions.  相似文献   

Anaerobic Treatment of Brackishwater Aquaculture Sludge: An Alternative to Waste Stabilization Ponds     

Natella Mirzoyan  Ryan Christopher McDonald  Amit Gross 《Journal of the World Aquaculture Society》2012,43(2):238-248

Environmental pressure, land utilization, and economic feasibility have resulted in the development of recirculating aquaculture systems (RAS). For many RAS, sludge is collected and washed from the system to waste stabilization ponds (WSPs). However, disposal of brackishwater aquaculture sludge into WSP is often prohibited because the high salinity can interfere with treatment. Moreover, there are problems associated with WSPs because of elevated salt content, such as the common practice of reusing treated water and land application of stabilized sludge. We tested and compared the treatment of brackishwater aquaculture sludge in an upflow anaerobic sludge blanket (UASB) reactor as an alternative to a WSP. In UASB, wastewater flows upward through a blanket of granular sludge and is treated by anaerobic micro‐organisms. Reduction in organic matter and 5‐d biochemical oxygen demand by 97 and 91%, respectively, was achieved in a UASB as compared to corresponding reductions of 22 and 41% in a WSP. During the UASB digestion process, methane is produced and recovered. Overall, a reduction in potential environmentally harmful factors such as salinization, land requirements, greenhouse gas emissions, as well as transportation costs are achieved, making the UASB reactor an attractive possible alternative for saline aquaculture sludge management.  相似文献