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The Pasteur and Crabtree effects demonstrate that changes at the beginning of the metabolic sequence for glucose metabolism give rise to effects at the end, and vice versa. We have presented here three additional responses of the ascites tumor cell suspensions, and presumably more will be uncovered. Each one of these responses is a manifestation of factors in the underlying mechanism that are in the nature of chemical feedback of a linear or nonlinear nature. The metabolic reactions are sufficiently complex that it is unlikely that any single component or step need control metabolism in different types of cells or under all conditions for a particular cell. However, it is due to a favorable circumstance that, in an appropriate type of cell and with the use of a direct intracellular indicator for changes in ADP concentration, we can state that the respiratory metabolism of the ascites tumor cell suspension, as freshly withdrawn from the mouse abdomen, is limited by the intracellular ADP concentration, and that this is why these cells show a predominance of glycolytic over respiratory activity. The response of the metabolism to small and large additions of glucose illustrates aspects of the metabolic mechanism which involve control of endogenous metabolism and compartmentalization of ATP formed in oxidative phosphorylation, the net result being a depression of the respiratory activity. The results of this approach emphasize the importance of chemical assays of localized portions of the living cell in its physiological state (61). 相似文献
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C Kerr L Bouré S Pearce C Martin WN McDonell 《Veterinary anaesthesia and analgesia》2003,30(2):113-113
The purpose of this study was to evaluate the cardiopulmonary effects of anesthetic induction with diazepam/ketamine or xylazine/ketamine with subsequent maintenance of anesthesia using isoflurane in foals undergoing abdominal surgery. Seventeen foals underwent laparotomy at 7–10 days of age and a laparoscopy 7–10 days later. Foals were randomly assigned to receive xylazine (0.8 mg kg?1)/ketamine (2 mg kg?1) (X/K)(n = 9) or diazepam (0.2 mg kg?1)/ketamine (2 mg kg?1) (D/K)(n = 8) for induction of anesthesia for both procedures. In all foals, anesthesia was maintained with isoflurane in oxygen with the inspired concentration adjusted to achieve adequate depth of anesthesia as assessed by an individual blinded to the treatments. IPPV was employed throughout using a tidal volume of 10 mL kg?1 adjusting the frequency to maintain eucapnia (PaCO2 35–45 mm Hg, 4.7–6.0 kPa). Cardiopulmonary variables were measured after induction of anesthesia prior to, during, and following surgery. To compare the measured cardiopulmonary variables between the two anesthetic regimes for both surgical procedures, results were analyzed using a three‐way factorial anova for repeated measures (p < 0.05). During anesthesia for laparotomy, mean CI and MAP ranged from 110 to 180 mL kg?1 minute?1 and 57–81 mm Hg, respectively, in the D/K foals and 98–171 mL kg?1 minute?1 and 50–66 mm Hg in the X/K foals. Overall, CI, HR, SAP, DAP, and MAP were significantly higher in foals in the D/K group versus the X/K group during this anesthetic period. During anesthesia for laparoscopy, mean CI and MBP ranged from 85 to 165 mL kg?1 minute?1 and 67–83 mm Hg, respectively, in the D/K group, and 98–171 mL kg?1 minute?1 and 48–67 mm Hg in the X/K group. Only HR, SAP, DAP, and MAP were significantly higher in the D/K group versus X/K group during this latter anesthetic period. There were no significant differences between groups during either surgical procedure for end‐tidal isoflurane, PaO2, PaCO2, or pH. In conclusion, anesthesia of foals for laparotomy and laparoscopy with diazepam/ketamine/isoflurane is associated with less hemodynamic depression than with xylazine/ketamine/isoflurane. 相似文献
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M. HESS G. BARRALIS H. BLEIHOLDER L. BUHR TH. EGGERS H. HACK R. STAUSS 《Weed Research》1997,37(6):433-441
The extended BBCH scale is a system for a uniform coding of phenologicaliy similar growth stages of all mono- and dicotyledonous plant species, based on the well known cereal code of Zadoks et al. (1974). The BBCH key is it decimal system, with 10 principal growth stages and up to 10 secondary ones, starting with seed germination, sprouting of perennials, progressing through leaf production and extension growth to flowering and senescence. Therefore, it can also be a suitable tool to define the growth stages of different weed species. To encourage further use of the BBCH scale in weed research, definitions of the codes have been more closely adapted to weeds. Possible problems are discussed and guidelines for correct use are given. 相似文献
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DARYL D. BUSS ROBERT E. HESS ALISTAIR I. WEBB KAREN R. SPENCER 《The Journal of small animal practice》1982,23(7):399-404
A total of 50 dogs, judged to be free of cardiovascular disease on the basis of physical and electrocardiographic (ECG) examination, underwent ECG monitoring during recovery from general anaesthesia. Fifteen of these dogs (30 per cent) developed some form of cardiac arrhythmia during the recovery period. The arrhythmias most frequently observed were premature ventricular contractions and atrioventricular conduction defects of varying degrees of severity. The observed arrhythmias had ceased by the end of the observation period and did not require specific therapy. There was no apparent correlation between the duration of anaesthesia, the type of medical or surgical procedure and the development of arrhythmias. However, the dogs developing arrhythmias were older than those that did not. The relatively high frequency of occurrence of cardiac arrhythmias must be considered in the evaluation of ECG data from dogs being monitored during recovery from anaesthesia. 相似文献