Pathology of infectious diarrhea of infant rats (IDIR) induced by an antigenically distinct rotavirus     

A C Huber  R H Yolken  L C Mader  J D Strandberg  S L Vonderfecht 《Veterinary pathology》1989,26(5):376-385

Suckling rats were inoculated with a group B rotavirus to determine the progression of the morphologic changes induced in the intestine by this virus. Several changes were observed by light microscopy 1 day after viral inoculation: shortening of small intestinal villi, villous epithelial necrosis, and villous epithelial syncytia. The lesions were most often present in the distal small intestine, although other small intestinal segments were affected to a lesser degree. By day 3 post-inoculation, epithelial necrosis, and syncytia were no longer present; however, the villous epithelium was disorganized and irregularly vacuolated, and intestinal crypt epithelium was hyperplastic. Alterations in villous height to crypt depth ratios were present in portions of the small intestine for the remainder of the 12-day study period. Epithelial syncytia appeared to form by the breakdown of the lateral interdigitating membranes of the absorptive villous epithelium. Viral particles, abundant in the syncytia, appeared to form from amorphous or reticular arrays of viral precursor material. Group B rotaviral antigens, as detected by indirect immunofluorescence, were present in large amounts in the small intestinal villous epithelium only on the first day after viral inoculation. These studies show that two important diagnostic features of group B rotaviral infections of rats, epithelial syncytia and viral antigen as determined by immunofluorescence, are present only on the first day of disease. These findings should be taken into consideration when attempting to diagnose disease induced by this agent.  相似文献   

Differences in Reproductive Performance, Embryo Development, Interferon-tau Secretion by the Conceptus and Luteal Function in Ewe Lambs Synchronized in Oestrus before or after the Spontaneous Onset of Luteal Activity Preceding Puberty     

JA Abecia  F Forcada  & O Zúñiga 《Reproduction in domestic animals》2001,36(2):73-77

In mid-September, 1 month before the insertion of intravaginal pessaries to induce sexual activity, blood samples were collected every 4 days from 16 ewe lambs aged 7 months, in order to determine the incidence of ovulations by measurement of plasma progesterone concentrations. It has been studied whether the response to a progestagen treatment of ewe lambs apparently close to puberty could be modified by the onset of the ovarian events preceding puberty. The effect of the presence or absence of ovulations prior to progestagen treatment on the potential reproductive performance (fertility, litter size and fecundity), embryo development [embryo quality and interferon-tau (IFNτ) secretion], luteal function (progesterone secretion in vitro ) and endometrial progesterone content was studied in seven ovulating (Ov+) and nine nonovulating ewe lambs (Ov−) on day 14 after mating. The best potential reproductive results were obtained with Ov+ animals, although these differences could not be initially attributed to either different progesterone secretion in vitro or concentration of endometrial progesterone. Irrespective of the experimental groups, secretion of progesterone by luteal tissue from ewe lambs with normal embryos was significantly greater (p<0.05) than that of animals with abnormal embryos or with no embryos. Normal embryos secreted a higher amount of IFN-τ than those embryos classified as abnormal (p<0.07). In conclusion, ewe lambs which exhibit luteal activity before puberty have the highest levels of reproductive performances after a progestagen treatment. Corpora lutea from ewe lambs with normal embryos had higher rates of progesterone secretion in vitro and their embryos had a higher IFN-τ production by the embryos, indicating greater capacity for subsequent development.  相似文献   

Crüffeln in der Oberpfalz     

Dr. Heinrich Huber 《European Journal of Forest Research》1938,60(1):34-36

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Ontario. Streptococcus pneumoniae Type 3 in an Ontario racehorse          下载免费PDF全文

Huber L  Willoughby R  Lynch J 《The Canadian veterinary journal. La revue veterinaire canadienne》1988,29(8):665-666

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Endotoxin absorption in hay-fed and lactic acidotic sheep.     

T L Huber  M C Peed  R C Wilson  D D Goetsch 《American journal of veterinary research》1979,40(6):792-794

Absorption of endotoxin from the gastrointestinal tract was evaluated in hay-fed and lactic acidotic sheep duodenally infused with 10 mg of Escherichia coli endotoxin, and in lactic acidotic sheep not infused. The effect of abomasal fluid on biological activity of endotoxin was also evaluated. Leukopenia was the criterion used for detecting endotoxemia. Absorption of endotoxin from the gastrointestinal tract was not detected in either hay-fed or lactic acidotic sheep. Endotoxin appeared to maintain its activity after incubation with abomasal fluid, and the presence of endogenous endotoxin in abomasal contents was indicated. The results indicate that endotoxin of alimentary origin may not be involved in the lactic acidosis syndrome in ruminants.  相似文献   

Virus‐neutralising antibody responses in horses following vaccination with Equivac® HeV: a field study          下载免费PDF全文

RHH Tan  A Hodge  R Klein  N Edwards  JA Huang  D Middleton  SP Watts 《Australian veterinary journal》2018,96(5):161-166

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Caecal intussusceptions in horses: a New Zealand perspective     

RJW Bell  JA Textor 《Australian veterinary journal》2010,88(7):272-276

Objective To establish the prevalence of intussusceptions involving the caecum in a population of horses admitted to a university hospital for colic. Design Retrospective clinical study Methods Medical records of all horses admitted to the Massey University Veterinary Teaching Hospital between 1991 and 2004 were examined for information of those horses diagnosed with an intussusception involving the caecum. Results A total of 135 horses were admitted for colic surgery during the study period and 61 horses had a diagnosis of ileocaecal (37), caecocaecal (5) or caecocolic intussusception (19) made either at surgery or necropsy. Of the horses with ileocaecal intussusception, 32 had an incomplete hand-sewn ileocaecostomy without reduction and 29 survived to discharge. All the horses with caecocaecal intussusceptions were diagnosed preoperatively via rectal examination and/or transabdominal ultrasound: 2 were euthanased at surgery and 3 survived to discharge. In the 19 horses with caecocolic intussusceptions, manually reduction at surgery was performed in 6 and 5 of them survived to discharge. A typhlectomy was performed via a colotomy in 6 horses, 3 of which survived to discharge. Conclusions The high prevalence of intussusceptions involving the caecum seen at this referral centre may indicate a higher prevalence in New Zealand than is reported elsewhere in the world. Clinical relevance Intussusceptions involving the caecum should be considered as a differential diagnosis in horses presenting with chronic low-grade colic. Transabdominal ultrasound is useful for identifying caecocaecal and caecocolic intussusceptions. Hand-sewn side-to-side incomplete ileocaecostomy is a quick, effective and safe method of surgical treatment of ileocaecal intussusceptions.  相似文献   

Metabolic changes induced by oral glucose tests in horses and their diagnostic use     

Julien Delarocque  Florian Frers  Karsten Feige  Korinna Huber  Klaus Jung  Tobias Warnken 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2021,35(1):597-605

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Medical management of Rhodococcus equi infections: A clinical epidemiology perspective     

L. Huber 《Equine Veterinary Education》2021,33(12):626-627

Rhodococcus equi infections cause severe pulmonary disease in foals, affecting animal welfare and increasing production costs in horse-breeding farms. Extra-pulmonary disorders (EPD) are relatively common and can occur independently of pulmonary disease; foals with EPD have a more guarded prognosis. The accompanying paper by Shaw et al. (2021) reports the successful diagnosis and medical treatment of a large abdominal abscess caused by R. equi infection. The authors report on the benefits of using gallium maltolate, a semimetal compound with antimicrobial activity, in combination with traditional R. equi infection antimicrobial treatment (combination of a macrolide and rifampicin). Experimental studies are needed to understand further the benefits of this combined therapy, to evaluate the synergistic effects and if it improves the concentration of antimicrobial drugs into infected tissues. The publication of this case report in Equine Veterinary Education is of clinical importance to equine practitioners when diagnosing and treating R. equi infected foals with or without EPD.  相似文献   

Versuche mit einem Prostaglandinanalog zur Zyklussynchronisation beim Rind unter hormonanalytischer und klinischer Kontrolle     

Von H. Karg  M. Hartl  B. Hoffmann  D. Schams  W. Schmidt  Von O. Günzler  E. Huber  S. Müller 《Reproduction in domestic animals》1976,11(1):7-18

1. Durch intramuskulare Injektion von 0,5 mg des Prostaglandinanalogs ICI 80 996 beim Rind während der Gelbkörperphase des Zyklus kann nach 15–24 Stunden ein Abfall der Progesteronwerte unter 1 ng/ml Blutplasma und damit eine nachhaltige Luteolyse erreicht werden. Die sich anschließende Brunst ist ovulatorisch und feral. Das Präparat wird ohne Nebenwirkungen vertragen. 2. Durch zweimalige Injektion (d. h. je 1 mal 0,5 mg i. m.) im Abstand von 11 Tagen kann dieser Luteolyseeffekt zu Brunstsynchronisationen herangezogen werden; dabei ist eine Zykluskontrolle oder Brunstbeobachtung nicht erforderlich. 3. in 8 Feldversuchen konnte bei 213 Tieren ein Synchronisationserfolg von 90,6 % und, nach KB in der 1. induzierten Brunst, ein Konzeptionsergebnis von 54,7 % (bzw. von 60,1 %, wenn man die Auswertung auf die erfolgreich synchronisierten Tiere beschränkt) erzielt werden. Die KB bei 119 nicht behandelten Kontrolltieren, die in 5 dieser 8 Versuche zur Verfugung standen, war zu 60,3 % erfolgreich. 4. In einem Problembestand konnte die Fertilitätslage durch das biotechnische Vorgehen der Prostaglandinanwendung unmittelbar nicht verbessert werden 5. Die palpatorischen Ovarbefunde zum Zeitpunkt der KB ergaben, daß Tiere mit aprungbereiten Follikeln'zu 65 %, mit kleinen, nicht reifen Follikeln zu 50,8 % und mit bereitsgesprungenen Follikeln zu 15,8 % konzipierten. 6. Die bei einem Teil der Versuche eingesetzte zusdtzliche Behandlung mit 1,0 bzw. 1,5 mg des Gonadotropin-Releasinghormons (LRH-Hoechst 471) i. m. zum Zeitpunkt der Besamung zeigte bezüglich des Konzeptionsergebnisses eine positive Tendenz.  相似文献