Critical and controlled tests of activity of a macrocyclic lactone (compound F28249-alpha) against natural infections in internal parasites of equids     

E T Lyons  J H Drudge  S C Tolliver 《American journal of veterinary research》1989,50(6):970-974

Thirteen critical tests (n = 11 horses and 2 ponies) and 4 controlled tests (n = 4 donkeys and 6 horses) were performed to evaluate the activity of the experimental macrocyclic lactone compound F28249-alpha against internal parasites of equids. In the critical tests, activity was determined mainly against the large parasites, but 1 critical test also included benzimidazole-resistant small strongyles. In the controlled tests, evaluation of drug activity included large parasites and stomach worms in all 4 tests, and lungworms in 2 tests. The period between treatment and euthanasia was 6 to 9 days for the critical tests and 14, 17, or 52 days for the controlled tests. The compound was administered by stomach tube at dose rates of 1, 2, 3, 3.5, or 4 mg/kg of body weight. In the critical tests, removal at all 5 dose rates was 100% for Gasterophilus nasalis (2nd and 3rd instars), Parascaris equorum (mature), Strongylus vulgaris, and Strongulus edentatus from the gastrointestinal tract. For Gasterophilus intestinalis in the stomach, mean removals of 2nd instars were 88% at the rate of 2 mg/kg and 93% to 100% at rates greater than or equal to 3 mg/kg. For 3rd instars, mean removals were 7% at 1 mg/kg, 77% at 2 mg/kg, 90% at 3 mg/kg, and 98% at 3.5 mg/kg. Discharge of G intestinalis in feces was typically a slow, prolonged process and probably higher removal values, especially at lower dose rates, would have attended a longer interval after treatment before necropsy examination.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

Lack of association between abortion and blood ammonia and methaemoglobin concentrations in dairy cows grazing imporved pastures on the Atherton Tableland     

JH NORTON  JP HOGAN 《Australian veterinary journal》1993,70(5):194-195

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An unresponsive progressive pustular and crusting dermatitis with acantholysis in nine cats          下载免费PDF全文

Catherine A. Outerbridge  Verena K. Affolter  Leslie A. Lyons  Samantha L. Crothers  Andrea T. H. Lam  Terri E. Bonenberger  Stephen D. White 《Veterinary dermatology》2018,29(1):81-e33

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Evaluation of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in critically ill dogs     

Lisa H. Dourmashkin BS  Bridget Lyons VMD  DAVCECC  Rebecka S. Hess DVM  DACVIM  Koranda Walsh VMD  DACVIM  DACVP  Deborah C. Silverstein DVM  DAVCECC 《Journal of Veterinary Emergency and Critical Care》2023,33(1):52-58

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Current prevalence of adult Uncinaria spp. in northern fur seal (Callorhinus ursinus) and California sea lion (Zalophus californianus) pups on San Miguel Island, California, with notes on the biology of these hookworms     

Lyons ET  Melin SR  DeLong RL  Orr AJ  Gulland FM  Tolliver SC 《Veterinary parasitology》2001,97(4):309-318

A prevalence survey for hookworms (Uncinaria spp.) was done in northern fur seal (Callorhinus ursinus) and California sea lion (Zalophus californianus) pups on San Miguel Island, CA, in 2000. Intestines of dead pups were examined for adult hookworms in July. These parasites were found in 95% of 20 fur seal pups and 100% of 31 sea lion pups. The number of hookworms varied from 4 to 2142 (mean = 760) in fur seal pups and from 20 to 2634 (mean = 612) in sea lion pups. A direct relationship was evident between body condition and number of hookworms in the pups; that is, pups in poor condition had fewer hookworms than those in good condition. There was a decline in the number of hookworms in sea lion pups in 2000 compared to collections in 1996. Eggs of Uncinaria spp. were found in rectal feces (collected in late September and early October) of none of 35 (0%) live fur seal pups and 41 of 48 (85%) live sea lion pups. Packed cell volume values, determined for most of the same live pups, were essentially normal for C. ursinus but were much lower than normal for most Z. californianus. Hookworm larvae were not found in blubber of fur seal and sea lion pups or in rookery sand in July. Rookery sand, positive for live hookworm larvae when put in a refrigerator, was negative at removal 2.5 years later. The average number of eggs in utero of female hookworms was 285 for three specimens from a fur seal pup and 281 from three specimens from a sea lion pup. One hookworm larva was recovered from milk stripped from the teats of a stranded Z. californianus female at The Marine Mammal Center, Sausalito, CA.  相似文献   

Critical and clinical test evaluations of mebendazole against internal parasites of the horse   总被引：3，自引：0，他引：3  

J H Drudge  E T Lyons  S C Tolliver 《American journal of veterinary research》1974,35(11):1409-1412

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Poor anchorage and growth of spur ‘Red Delicious’ apple trees with deep crown roots     

C.G. Lyons  K.S. Yoder  R.E. Byers 《Scientia Horticulturae》1982,18(1):45-47

Spur ‘Red Delicious’ apple Malus domestica (Bork.) trees on MM 111 and seedlings that had been blown over by high winds had greater depth to first root and had thinner trunks than adjacent undamaged trees.  相似文献   

The 5-minute veterinary consult: ferret and rabbit - Edited by Oglesbee BL     

JH Lewington 《Australian veterinary journal》2007,85(3):106-106

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含莫纳可林K红曲降低鸡蛋胆固醇效果的研究   总被引：1，自引：0，他引：1  

李春雨  蔡吉光  李继红  李秀敏 《中国兽药杂志》2006,40(8):28-30

48只68周龄的海兰褐蛋鸡分成三组，按0.5％和10％比例分别添加含0．4％莫纳可林K红曲于各组日粮内，饲喂22d，观测其对鸡蛋胆固醇变化的影响。结果表明，投药后5—6d，10％添加组和5％添加组蛋黄胆固醇开始下降；15—22d的胆固醇含量与1～5d相比，10％添加组和5％添加组分别下降了9．02％和5．10％，而对照组升高了5．22％。  相似文献   

氧氟沙星药物的研究进展   总被引：2，自引：0，他引：2  

唐建华  姜波  刘昌林  邓开峰 《中国兽药杂志》2007,41(9):29-33

通过对氧氟沙星药物近十年来的检测方法、药代动力学、药效学、耐药性及抗菌后效应、联合应用及毒理学、残留及残留的检测方法等六个方面的大量研究资料进行综述,详细介绍并论述了氧氟沙星药物在这些方面的最新研究成果,对氧氟沙星药物及其他喹诺酮类药物的进一步研究、开发和应用具有指导意义。  相似文献