What is your diagnosis? Absence of the radius     

A J Payton  S E Moos  R L Pulver  W J Maier 《Journal of the American Veterinary Medical Association》1989,194(8):1105-1106

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Mutants of Rhizobium japonicum with Increased Hydrogenase Activity     

Merberg D  Maier RJ 《Science (New York, N.Y.)》1983,220(4601):1064-1065

Some strains of Rhizobium japonicum can use hydrogen as an energy source for growth under microaerophilic conditions. Mutant strains have been selected that use hydrogen in the presence of high partial pressures of oxygen. The mutants contain more hydrogenase than the parent strain, both as free-living cells and as bacteroids in nitrogen-fixing soybean root nodules.  相似文献   

Oestradiol Induced Inhibition of Neuroendocrine Marker Expression in Leydig Cells of Adult Rats     

HH Ortega  NR Salvetti  C Baravalle  JA Lorente  GA Mira 《Reproduction in domestic animals》2006,41(3):204-209

The objectives of this work were to determine the changes in the expression of neuroendocrine markers in Leydig cell by oestradiol treatment, and to determine whether testosterone is able to recover partially the effects of hormonal suppression induced by oestradiol. Adult male rats were injected daily with either 50 microg of oestradiol or oestradiol plus testosterone propionate (25 mg every 3 days) for 15 days. The animals were sacrificed and testicles were dissected and processed by routine histological protocols. FSH and LH serum levels were determined by radioimmunoassay. The visualization of antigens was achieved by the streptavidin-peroxidase immunohistochemical method. Antibodies against chromogranin A (CrA), S-100 protein (S-100), P substance (PS), synaptofisin (SYN), neurofilament protein (NF), gliofibrillary acidic protein (GFAP) and neuron specific enolase (NSE) were used. The mean LH and FSH serum concentrations were consistently suppressed with hormonal treatments. Intermediate filaments (NF and GFAP) showed no difference in their expression. The expression of S-100, NSE and SYN was significantly lower in both hormone-treated groups. In oestradiol-treated rats, the immunoreactivity of CrA and SP decreased significantly but was restored after testosterone supplementation. Although the nature and functions of many of these substances in Leydig cells remain unknown, these results are consistent with the hypothesis that the expression of some neuroendocrine markers is hormonally controlled.  相似文献   

Effects of temperature and tissue nitrogen on dormant season stem and branch maintenance respiration in a young loblolly pine (Pinus taeda) plantation     

Maier CA  Zarnoch SJ  Dougherty PM 《Tree physiology》1998,18(1):11-20

We measured dormant season (November through February) maintenance respiration rates (R(m)) in stems and branches of 9-year-old loblolly pine (Pinus taeda L.) growing in plots under conditions of controlled nutrient and water supply in an effort to determine the relationships between R(m) and tissue size (surface area, sapwood volume, sapwood dry weight), tissue nitrogen content and temperature. Dormant season R(m) per unit size (i.e., surface area, &mgr;mol m(-2) s(-1); sapwood volume, &mgr;mol m(-3) s(-1); or sapwood dry weight, nmol g(-1) s(-1)) varied with tissue size, but was constant with respect to tissue nitrogen content (&mgr;mol mol(-1) N s(-1)). Cambium temperature accounted for 61 and 77% of the variation in stem and branch respiration, respectively. The basal respiration rate (respiration at 0 degrees C) increased with tissue nitrogen content, however, the Q(10) did not. Improved nutrition more than doubled stem basal respiration rate and increased branch basal respiration by 38%. Exponential equations were developed to model stem and branch respiration as a function of cambium temperature and tissue nitrogen content. We conclude that failure to account for tissue nitrogen effects on respiration rates will result in serious errors when estimating annual maintenance costs.  相似文献   

THE TREATMENT OF "SNIFFLES" IN THE RAT WITH SULFANILAMIDE     

Maier NR 《Science (New York, N.Y.)》1938,87(2263):439-441

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Wünsche und Erwartungen der erholungsuchenden Menschen oder: Haben die «veränderten gesellschaftlichen Rahmenbedingungen» auch zu einer «Trendwende» im Freizeitbereich beigetragen?     

J. Maier 《European Journal of Forest Research》1983,102(1):239-251

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Atmospheric carbon dioxide, irrigation, and fertilization effects on phenolic and nitrogen concentrations in loblolly pine (Pinus taeda) needles     

Booker FL  Maier CA 《Tree physiology》2001,21(9):609-616

Concentrations of total soluble phenolics, catechin, proanthocyanidins (PA), lignin and nitrogen (N) were measured in loblolly pine (Pinus taeda L.) needles exposed to either ambient CO(2) concentration ([CO(2)]), ambient plus 175 or ambient plus 350 micromol CO(2) mol(-1) in branch chambers for 2 years. The CO(2) treatments were superimposed on a 2 x 2 factorial combination of irrigation and fertilization treatments. In addition, we compared the effects of branch chambers and open-top chambers on needle chemistry. Proanthocyanidin and N concentrations were measured in needles from branch chambers and from trees in open-top chambers exposed concurrently for two years to either ambient [CO(2)] or ambient plus 200 micromol CO(2) mol(-1) in combination with a fertilization treatment. In the branch chambers, concentrations of total soluble phenolics in needles generally increased with needle age. Concentrations of total soluble phenolics, catechin and PA in needle extracts increased about 11% in response to the elevated [CO(2)] treatments. There were no significant treatment effects on foliar lignin concentrations. Nitrogen concentrations were about 10% lower in needles from the elevated [CO(2)] treatments than in needles from the ambient [CO(2)] treatments. Soluble phenolic and PA concentrations were higher in the control and irrigated soil treatments in about half of the comparisons; otherwise, differences were not statistically significant. Needle N concentrations increased 23% in response to fertilization. Treatment effects on PA and N concentrations were similar between branch and open-top chambers, although in this part of the study N concentrations were not significantly affected by the CO(2) treatments in either the branch or open-top chambers. We conclude that elevated [CO(2)] and low N availability affected foliar chemical composition, which could in turn affect plant-pathogen interactions, decomposition rates and mineral nutrient cycling.  相似文献   

Isolation of new limonoate dehydrogenase from Pseudomonas   总被引：1，自引：0，他引：1  

S Hasegawa  V P Maier  A D King 《Journal of agricultural and food chemistry》1974,22(3):523-526

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The crystal structure of a mammalian fatty acid synthase     

Maier T  Leibundgut M  Ban N 《Science (New York, N.Y.)》2008,321(5894):1315-1322

Mammalian fatty acid synthase is a large multienzyme that catalyzes all steps of fatty acid synthesis. We have determined its crystal structure at 3.2 angstrom resolution covering five catalytic domains, whereas the flexibly tethered terminal acyl carrier protein and thioesterase domains remain unresolved. The structure reveals a complex architecture of alternating linkers and enzymatic domains. Substrate shuttling is facilitated by flexible tethering of the acyl carrier protein domain and by the limited contact between the condensing and modifying portions of the multienzyme, which are mainly connected by linkers rather than direct interaction. The structure identifies two additional nonenzymatic domains: (i) a pseudo-ketoreductase and (ii) a peripheral pseudo-methyltransferase that is probably a remnant of an ancestral methyltransferase domain maintained in some related polyketide synthases. The structural comparison of mammalian fatty acid synthase with modular polyketide synthases shows how their segmental construction allows the variation of domain composition to achieve diverse product synthesis.  相似文献   

Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer   总被引：24，自引：0，他引：24  

J A Maier  P Voulalas  D Roeder  T Maciag 《Science (New York, N.Y.)》1990,249(4976):1570-1574

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