Primary tonsillar mast cell tumour in a dog          下载免费PDF全文

CC Shekell  MJ Thomson  RI Miller  JT Mackie 《Australian veterinary journal》2018,96(5):184-187

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Idiopathic eosinophilic colitis lesions of the equine small (descending) colon          下载免费PDF全文

M. P. de Bont  A. J. Malbon  R. Blundell  D. C. Archer 《Equine Veterinary Education》2018,30(9):466-471

Five horses with a primary surgical lesion of the small (descending) colon were diagnosed with eosinophilic colitis based on visual and histopathological examination. These were evident as visibly striking, hyperaemic, focal lesions of the small colon, with serosal petechiation, oedema and marked thickening of the intestinal wall at the site. Areas of focal necrosis were also evident. The gross appearance of the lesions were considered to be sufficiently severe in all cases to merit resection, due to concerns about intestinal necrosis and septic peritonitis. An inability to fully exteriorise the affected portion of intestine to perform a resection and anastomosis necessitated intraoperative euthanasia of one horse. A total of three horses survived to hospital discharge. Eosinophilic colitis lesions are a rare cause of severe small colon disease, but should be considered in cases with similar visual characteristics.  相似文献   

Otto Martin Radostits 1934 – 2006     

DC Blood  CC Gay  KW Hinchcliff  PD Constable 《Australian veterinary journal》2007,85(6):231-231

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Efficacy of avermectin B₁ given orally against equine intestinal strongyles and Onchocera microfilaria     

TD MOGG †  CC POLLITT  JP WILLMORE  H. THOMPSON ‡ 《Australian veterinary journal》1990,67(11):399-401

Three groups of horses and ponies (N = 13, 13 and 12) were treated with ivermectin paste (0.2 mg/kg p.o.), avermectin B1 solution (0.2 mg/kg p.o.), or fenbendazole suspension (10 mg/kg via nasogastric tube). The avermectin B1 was a 1% solution in a propylene glycolglycerol formal base. Faecal strongyle egg counts were performed before, and 14, 28, 42, 56 and 70 d, after treatment. Full-thickness skin biopsies from the neck, pectoral and umbilical regions were examined for Onchocera microfilaria before treatment, and again 14 and 70 d later. Ivermectin therapy produced a significant (P less than 0.01) decrease in mean strongyle egg counts 14, 28, 42 and 56 d after treatment. Avermectin B1 therapy resulted in significant (P less than 0.01) decreases in mean strongyle egg counts 14, 28 and 42 d after treatment. All horses given ivermectin or avermectin B1 had zero strongyle egg counts 14 and 28 d after treatment. Fenbendazole failed to significantly decrease strongyle egg counts. Both ivermectin and avermectin B1 resulted in zero microfilaria counts in all horses 14 d after treatment. On day 70 the percentage decrease in microfilaria counts were 100% and 99.6% respectively. Fenbendazole failed to significantly decrease microfilaria counts. The oral administration of this formulation of avermectin B1 appeared to be highly efficacious against intestinal strongyles and Onchocera microfilaria. The duration of anti-strongyle activity was, however, significantly (P less than 0.01) shorter than that of ivermectin paste.  相似文献   

Closing wedge ostectomy and medial distal tibia plate application for treatment of severe bilateral angular limb deformities in the hindlimbs of an 8-month-old foal     

B. Lindt  A. E. Fürst  F. Del Chicca  A. Malbon  M. A. Jackson 《Equine Veterinary Education》2022,34(6):e218-e227

This case report describes the evaluation, surgical approach and outcome of an 8-month-old foal with severe angular limb deformities of both metatarsophalangeal joints (MTPJ). Radiography and computed tomography (CT) were used to diagnose a windswept deformity of the hindlimbs with associated bilateral physitis. The orthopaedic surgery was planned and rehearsed using three-dimensional (3D) bone models. A bilateral closing wedge ostectomy was performed on the distal MtIII, and 3.5 mm LCP^® medial distal tibia plates were used bilaterally for osteosynthesis. Even though convalescence was prolonged and complicated by partial unilateral implant failure and osteoarthritis (OA), reduction of the deformities was successful and resulted in a sound foal.  相似文献   

An abattoir survey of equine dental abnormalities in Queensland,Australia          下载免费PDF全文

T Chinkangsadarn  GJ Wilson  RM Greer  CC Pollitt  PS Bird 《Australian veterinary journal》2015,93(6):189-194

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Monitoring distances travelled by horses using GPS tracking collars     

BA Hampson  JM Morton  PC Mills  MG Trotter  DW Lamb  CC Pollitt 《Australian veterinary journal》2010,88(5):176-181

Objective The aims of this work were to (1) develop a low-cost equine movement tracking collar based on readily available components, (2) conduct preliminary studies assessing the effects of both paddock size and internal fence design on the movements of domestic horses, with and without foals at foot, and (3) describe distances moved by mares and their foals. Additional monitoring of free-ranging feral horses was conducted to allow preliminary comparisons with the movement of confined domestic horses. Procedures A lightweight global positioning system (GPS) data logger modified from a personal/vehicle tracker and mounted on a collar was used to monitor the movement of domestic horses in a range of paddock sizes and internal fence designs for 6.5-day periods. Results In the paddocks used (0.8–16 ha), groups of domestic horses exhibited a logarithmic response in mean daily distance travelled as a function of increasing paddock size, tending asymptotically towards approximately 7.5 km/day. The distance moved by newborn foals was similar to their dams, with total distance travelled also dependent on paddock size. Without altering available paddock area, paddock design, with the exception of a spiral design, did not significantly affect mean daily distance travelled. Feral horses (17.9 km/day) travelled substantially greater mean daily distances than domestic horses (7.2 km/day in 16-ha paddock), even when allowing for larger paddock size. Conclusions Horses kept in stables or small yards and paddocks are quite sedentary in comparison with their feral relatives. For a given paddock area, most designs did not significantly affect mean daily distance travelled.  相似文献   

G protein signaling from activated rat frizzled-1 to the beta-catenin-Lef-Tcf pathway     

Liu T  DeCostanzo AJ  Liu X  Wang Hy  Hallagan S  Moon RT  Malbon CC 《Science (New York, N.Y.)》2001,292(5522):1718-1722

The frizzled receptors, which mediate development and display seven hydrophobic, membrane-spanning segments, are cell membrane-localized. We constructed a chimeric receptor with the ligand-binding and transmembrane segments from the beta2-adrenergic receptor (beta2AR) and the cytoplasmic domains from rat Frizzled-1 (Rfz1). Stimulation of mouse F9 clones expressing the chimera (beta2AR-Rfz1) with the beta-adrenergic agonist isoproterenol stimulated stabilization of beta-catenin, activation of a beta-catenin-sensitive promoter, and formation of primitive endoderm. The response was blocked by inactivation of pertussis toxin-sensitive, heterotrimeric guanine nucleotide-binding proteins (G proteins) and by depletion of Galphaq and Galphao. Thus, G proteins are elements of Wnt/Frizzled-1 signaling to the beta-catenin-lymphoid-enhancer factor (LEF)-T cell factor (Tcf) pathway.  相似文献   

Population dynamics of feral horses (Equus caballus) following above‐average rainfall in a semi‐arid environment of Australia     

S Kampmann  BA Hampson  CC Pollitt 《Australian veterinary journal》2013,91(11):482-487

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Caecal lipomatosis as a cause of colic in a 9‐year‐old gelding     

M. P. de Bont  A. J. Malbon  D. Sardon  D. C. Archer 《Equine Veterinary Education》2013,25(5):241-244

Lipomatosis is an uncommon cause of colic. This case report details the pre‐ and intraoperative findings of a 9‐year‐old gelding, presented with acute abdominal pain. Exploratory laparotomy revealed a massive fatty infiltrate involving an extensive portion of the base and mid‐body of the caecum. To the authors' knowledge, this is the first report of an infiltrative lipomatous lesion of the equine caecum.  相似文献