Macroglobulin-producing plasma-cell tumor in mice: identification of a new light chain   总被引：12，自引：0，他引：12  

K R McIntire  R M Asofsky  M Potter  E L Kuff 《Science (New York, N.Y.)》1965,150(694):360-363

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Flow effects on prostacyclin production by cultured human endothelial cells   总被引：61，自引：0，他引：61  

J A Frangos  S G Eskin  L V McIntire  C L Ives 《Science (New York, N.Y.)》1985,227(4693):1477-1479

Endothelial cell functions, such as arachidonic acid metabolism, may be modulated by membrane stresses induced by blood flow. The production of prostacyclin by primary human endothelial cell cultures subjected to pulsatile and steady flow shear stress was measured. The onset of flow led to a sudden increase in prostacyclin production, which decreased to a steady rate within several minutes. The steady-state production rate of cells subjected to pulsatile shear stress was more than twice that of cells exposed to steady shear stress and 16 times greater than that of cells in stationary culture.  相似文献   

Continued freedom from blue-tongue virus infection in cattle and sheep in Western Australia south of latitude 26° S     

TM ELLIS  R. TURNOR  TT NGUYEN  U. TARNOWSKI 《Australian veterinary journal》1996,74(4):317-319

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Hunting behavior of a marine mammal beneath the antarctic fast Ice   总被引：1，自引：0，他引：1  

RW Davis  LA Fuiman  TM Williams  SO Collier  WP Hagey  SB Kanatous  S Kohin  M Horning 《Science (New York, N.Y.)》1999,283(5404):993-996

The hunting behavior of a marine mammal was studied beneath the Antarctic fast ice with an animal-borne video system and data recorder. Weddell seals stalked large Antarctic cod and the smaller subice fish Pagothenia borchgrevinki, often with the under-ice surface for backlighting, which implies that vision is important for hunting. They approached to within centimeters of cod without startling the fish. Seals flushed P. borchgrevinki by blowing air into subice crevices or pursued them into the platelet ice. These observations highlight the broad range of insights that are possible with simultaneous recordings of video, audio, three-dimensional dive paths, and locomotor effort.  相似文献   

Pulmonary Maturation in Canine Foetuses From Early Pregnancy to Parturition     

TM Sipriani  F Grandi  LCG da Silva  PC Maiorka  CI Vannucchi 《Reproduction in domestic animals》2009,44(S2):137-140

Development of the foetal respiratory system includes both pulmonary growth and maturation. In human medicine, a higher incidence of respiratory distress is reported in newborn males. This study aimed to identify different phases of canine foetal lung maturation throughout pregnancy, to determine the stage of pregnancy in which surfactant production begins and to compare pulmonary development of male and female foetuses. Pregnant bitches (34) were subjected to elective ovariohysterectomy and allocated into four groups, according to the stage of pregnancy: 30–40 days of pregnancy (n = 10), 41–50 days (n = 10), 51–60 days (n = 10) and bitches in the first stage of parturition (n = 4). Foetal lungs were histologically processed and evaluated by optical microscopy. The pseudoglandular phase was identified between the 35th day and 46th day of gestation; the onset of canalicular and saccular periods was observed, respectively, from the 48th day and 60th day of pregnancy. Lungs from foetuses at term were in the saccular phase; thus, the development into the alveolar period occurs in the neonatal period. The histological analyses revealed that respiratory tract development is centrifugal, from upper to lower airways. Therefore, it is possible to identify distinct development periods in different portions of the same organ. In conclusion, the saccular phase of lung development begins around 57 and 60 days of pregnancy, the period in which surfactant production is believed to occur. Male and female foetuses present similar pulmonary development from early pregnancy until parturition.  相似文献   

Evaluating functional connectivity with matrix behavior uncertainty for an endangered butterfly   总被引：1，自引：1，他引：0  

Paul M. Severns  Eliot J. B. McIntire  Cheryl B. Schultz 《Landscape Ecology》2013,28(3):559-569

Understanding animal responses to landscape elements helps forecast population reactions to changing landscape conditions. The challenge is that some behaviors are poorly known and difficult to estimate. We assessed how uncertainty in behavioral responses to dense woods, an avoided landscape structure, impacts functional connectivity among reproductive habitat patches for Fender’s blue butterfly, an endangered prairie species of western Oregon, USA. We designed a factorial simulation experiment using a spatially explicit individual-based model to project functional connectivity for female butterflies across current and alternative landscapes. We varied the probability of dense woods entry and turning angle standard deviation for movements within the dense woods over a range of biologically reasonable and observed values. Butterflies in the current landscape (46 % dense woods) and one with prairie encroached by forest (60 % dense woods) showed reductions in functional connectivity estimates consistent with the expectations of habitat fragmentation. Although dense woods entrance uncertainty impacted functional connectivity projections, uncertainty in the dense woods turning angle standard deviation had comparatively little impact on connectivity estimates. Reduction and reconfiguration of the current dense woods to 27 % cover (restored landscape) appeared to facilitate a corridor behavior in dispersing individuals, likely providing a functional connectivity estimate comparable to the historic landscape (<5 % dense woods). Our simulations suggest that additional study of butterfly movement within the dense woods is unnecessary and that a partial reduction in dense woods would be sufficient to achieve historic levels of functional connectivity for Fender’s blue across the study landscape.  相似文献   

Importance of Staphylococcus hyicus ssp hyicus as a cause of arthritis in pigs up to 12 weeks of age     

BD HILL  BG CORNEY  TM WAGNER 《Australian veterinary journal》1996,73(5):179-181

Lame pigs, up to 12 weeks of age, were necropsied to establish a diagnosis. Of 175 pigs examined, 165 were confirmed to have arthritis by histopathological examination of joint tissues. Lesions were most common in the elbow and tarsal joints and least common in the joints of the feet. Typically, there was severe fibrinopurulent inflammation of synovial membranes regardless of the bacteria isolated. A bacterial aetiology was found in 114 (69%) of the 165 pigs. In arthritic pigs in which an aetiology was established the causative agents were Staphylococcus hyicus ssp hyicus (24.6%), Streptococcus equisimilis (26.3%), Actinomyces pyogenes (13.2%), Staphylococcus aureus (7.9%) and Haemophilus parasuis (7.9%). While gender did not affect the prevalence of arthritis, there was an age influence, most of the pigs culled for arthritis being under 6 weeks of age.  相似文献   

Encephalomyocarditis virus infection in pigs     

AR MERCY  RL PEET †  TM ELLIS †  J. PARKINSON † 《Australian veterinary journal》1988,65(11):355-355

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Government Animal Health Laboratory Services in Western Australia   总被引：1，自引：1，他引：0  

RB RICHARDS  TM ELLIS  JG ALLEN 《Australian veterinary journal》1993,70(9):321-323

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A comparison of two intramuscular doses of xylazine–ketamine combination and tolazoline reversal in llamas     

WR  DuBois  TM Prado  JCH Ko  RE Mandsager  GL Morgan 《Veterinary anaesthesia and analgesia》2003,30(2):114-115

The anesthetic and cardiorespiratory effects of a low dose (LD, 0.4 mg kg^?1 xylazine and 4 mg kg^?1 ketamine) and a high dose (HD, 0.8 mg kg^?1 xylazine and 8 mg kg^?1 ketamine) of IM xylazine–ketamine combination were compared in a randomized cross‐over study using six castrated male llamas. Three llamas in each dosage group (LDT, HDT) were assigned to receive IM tolazoline (2 mg kg^?1) after 30 minutes of recumbency. All IM injections were given in the semitendinosus or semimembranosus muscles. Pulse, respiratory rate, and indirect arterial blood pressure were recorded every 10 minutes, and hemoglobin oxygen saturation was recorded every 5 minutes during lateral recumbency. Samples for arterial blood gas analysis were collected 5 minutes following recumbency and every 30 minutes thereafter. Base‐to‐apex ECG was monitored continuously. Analgesia was evaluated every 5 minutes by both a 30 minutes skin pinch and a needle prick of the toe. Most llamas breathed room air throughout anesthesia. Two llamas that developed severe hypoxemia (SpO₂ < 75%) received 5 minutes of nasal oxygen insufflation, but were maintained on room air for the rest of the anesthetic period. anova for repeated measures and Tukey's test were used to analyze cardiorespiratory data. Fischer's exact test was used to compare the ability of each to provide >30 minutes of lateral recumbency and analgesia. A p‐value < 0.05 was considered significant. Both dosages provided reasonably rapid induction following injection (LD: 10.8 ± 6.3 minutes; HD: 5.0 ± 1.1 minutes; p = 0.07). Duration of lateral recumbency and analgesia were 34.7 ± 6.7 and 27.3 ± 4.6 minutes, respectively, in the LDT llamas. None of the three remaining LD llamas remained in lateral recumbency for longer than 12 minutes. Duration of lateral recumbency and analgesia were 87.3 ± 18.5 and 67.7 ± 16.0 minutes, respectively, for the HD llamas that did not receive tolazoline. The HDT llamas were recumbent for a significantly shorter time (43.3 ± 0.6 minutes; p = 0.05). The ability to provide >30 minutes of recumbency and analgesia was better in the HD group (6/6) than in the LD group (2/6) (p = 0.03). No differences between dosages were seen in pulse rate, respiratory rate, or arterial pressures. No ECG abnormalities were seen. Transient hypoxemia was seen in the first 10 minutes of lateral recumbency in the HD group by both hemoglobin oxygen saturation (84 ± 9.5%) and by blood gas PaO₂ (44.5 ± 5.8 mm Hg). It was concluded that the HD provided more consistent results than the LD, but induced transient hypoxemia. Tolazoline shortened the recovery time in llamas receiving the HD.  相似文献