Laryngeal mask airway and transient hypercapnic hyperpnea for video‐endoscopic assessment of unilateral laryngeal paralysis in dogs          下载免费PDF全文

Daniel M. Sakai MV  DACVAA  Manuel Martin‐Flores MV  DACVAA  Amanda K. Jones PhD  Galina M. Hayes BVSc  PhD  DACVECC  DACVS‐SA  Marina J. McConkey DVM  DACVS‐SA  Jonathan Cheetham VetMB  PhD  DACVS‐LA 《Veterinary surgery : VS》2018,47(4):543-548

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Use of clomipramine,alprazolam, and behavior modification for treatment of storm phobia in dogs     

Crowell-Davis SL  Seibert LM  Sung W  Parthasarathy V  Curtis TM 《Journal of the American Veterinary Medical Association》2003,222(6):744-748

OBJECTIVE: To evaluate use of clomipramine, alprazolam, and behavior modification for treatment of storm phobia in dogs. DESIGN: Prospective open clinical trial. ANIMALS: 40 dogs with storm phobia. PROCEDURE: Dogs received clomipramine at a dosage of 2 mg/kg (0.9 mg/lb), PO, every 12 hours for 3 months; then 1 mg/kg (0.45 mg/lb), PO, every 12 hours for 2 weeks; then 0.5 mg/kg (0.23 mg/lb), PO, every 12 hours for 2 weeks. Alprazolam was given at a dosage of 0.02 mg/kg (0.009 mg/lb), PO, as needed 1 hour before anticipated storms and every 4 hours as needed. Desensitization and counter-conditioning were conducted at home by the caregiver with an audio simulation of storm sounds that had induced a fear response during evaluation. RESULTS: 30 of the 32 dogs that completed the study had a degree of improvement, as measured by caregivers' global assessment. Two caregivers considered the storm phobia to be resolved. Panting, pacing, trembling, remaining near the caregiver, hiding, excessive salivation, destructiveness, excessive vocalization, self-trauma, and inappropriate elimination all decreased significantly during treatment. Improvement was greater during true storms (rain, thunder, and lightning) than during rain only. Response to audio simulation did not change during treatment. Four months after the study, improvement was maintained. CONCLUSIONS AND CLINICAL RELEVANCE: The combination of clomipramine, alprazolam, and behavior modification can be effective in decreasing or eliminating storm phobia. Improvement could not be evaluated by use of audio simulation of a storm.  相似文献   

Reduction and recovery of N-acetylglucosamine-1-phosphate transferase activity in the liver of sheep and rats after a single subcutaneous dose of tunicamycin     

PL STEWART  C MAY CSIRO  MV JAGO 《Australian veterinary journal》1998,76(4):287-288

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Correlation Between Liver Volume,Portal Vascular Anatomy,and Hepatic Perfusion in Dogs With Congenital Portosystemic Shunt Before and After Placement of Ameroid Constrictors     

Leticia Daniel MV  Michele A. Steffey DVM  Diplomate ACVS  Philipp D. Mayhew BVM&S  Diplomate ACVS  Kelli N. Mayhew VMD  Diplomate ACVS  William T. N. Culp VMD  Diplomate ACVS  Geraldine B. Hunt BVSc  PhD  FACVSc 《Veterinary surgery : VS》2014,43(8):926-934

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Coherent spin oscillations in a disordered magnet     

Ghosh S  Parthasarathy R  Rosenbaum TF  Aeppli G 《Science (New York, N.Y.)》2002,296(5576):2195-2198

Most materials freeze when cooled to sufficiently low temperature. We find that magnetic dipoles randomly distributed in a solid matrix condense into a spin liquid with spectral properties on cooling that are the diametric opposite of those for conventional glasses. Measurements of the nonlinear magnetic dynamics in the low-temperature liquid reveal the presence of coherent spin oscillations composed of hundreds of spins with lifetimes of up to 10 seconds. These excitations can be labeled by frequency and manipulated by the magnetic fields from a loop of wire and can permit the encoding of information at multiple frequencies simultaneously.  相似文献   

Conformational variability of NAD+ in the free and bound states: a nicotinamide sandwich in NAD+ crystals   总被引：1，自引：0，他引：1  

R Parthasarathy  S M Fridey 《Science (New York, N.Y.)》1984,226(4677):969-971

X-ray analysis of the free-acid crystal form of the coenzyme nicotinamide adenine dinucleotide (NAD+) revealed a conformational difference between the free NAD+ molecule and one bound in enzymes or complexed to Li+ ions. The pyrophosphate group showed asymmetry in the phosphate-oxygen bonds of the phosphate-oxygen-phosphate link; this bond at the nicotinamide side of the link is longer than that at the adenosine side by 0.04 angstrom. The crystal structure showed a novel intermolecular stacking of adenine and water molecules on opposite sides of nicotinamide that gives rise to a nicotinamide sandwich.  相似文献   

Trichuris suis excretory secretory products (ESP) elicit interleukin-6 (IL-6) and IL-10 secretion from intestinal epithelial cells (IPEC-1)     

Parthasarathy G  Mansfield LS 《Veterinary parasitology》2005,131(3-4):317-324

Immune responses to gastrointestinal helminth infections have received increasing attention due to similarities to allergen-induced responses. In fact, the whipworm parasite of swine, Trichuris suis, has been used in beginning clinical trials as an antidote to inflammatory bowel disease. This strategy was based on this similarity and the recognition that other worms have been documented to induce anti-inflammatory responses in the host. In an effort to understand the basis for this response, we hypothesized that the proteins and peptides secreted by T. suis stimulate local intestinal epithelial cells to produce anti-inflammatory cytokines. To test this hypothesis in a correlate system of the natural swine host, T. suis excretory secretory products (ESP) were used to treat both differentiated and undifferentiated intestinal pig epithelial cells (IPEC-1) in vitro as a model for the effect on villus tip and crypt epithelial cells in the vicinity of the worms. IPEC-1 were exposed to low-level doses (0.3mg/ml) of T. suis ESP, and IL-4, IL-6 and IL-10 cytokine responses were measured by an enzyme-linked immunosorbant assay (ELISA). IL-6 was the predominant cytokine produced, accompanied by moderate IL-10 secretion from both differentiated and undifferentiated cells. As expected, IL-4 was not produced by IPEC-1. Additionally, IL-6 and IL-10 cytokines were produced within 24h, suggesting that these two cytokines form part of the primary host response to T. suis infections. These data suggest that T. suis ESP could enhance host immune responses and modulation through the induction of enteric IL-6 and IL-10.  相似文献   

Oestrogen,Progesterone and Oxytocin Receptors and COX‐2 Expression in Endometrial Biopsy Samples from the Induction of Ovulation to Luteolysis in Llamas (Lama glama)     

CP Bianchi  A Meikle  MA Alvarez  MA Benavente  MV Cavilla  E Rodríguez  MA Aba 《Reproduction in domestic animals》2013,48(4):681-690

Endometrial expression of oestrogen (ERα), progesterone (PR) and oxytocin receptor (OR) and cyclooxygenase‐2 (COX‐2) was evaluated from the induction of ovulation to luteolysis in llamas. Ovarian activity was daily assessed by ultrasonography in five females. Ovulation was induced immediately after the detection of an ovulatory follicle by a GnRH injection (Day 0). Endometrial samples were obtained by transcervical biopsies from the left and right horns on day 0 and days 4, 8, 10 and 12 post‐GnRH. Blood samples were collected daily for progesterone and estradiol‐17β determinations by RIA. An immunohistochemical technique was used to study receptors population and COX‐2 expression which were then evaluated by two independent observers. The expression of ERα and PR was highest on day 0 in the luminal epithelium and stroma in association with high plasma estradiol‐17β concentrations. Thereafter, a decrease in ERα population was registered on day 4 and a new increase of its expression was observed between days 8 and 12 in those cell types. Conversely, PR population was gradually down‐regulated until its lowest expression was reached on day 10 post‐GnRH in the luminal epithelium. Content of OR was similar throughout the study in all cell types. The expression of COX‐2 was highest from day 8 to 12 post‐GnRH in the luminal epithelium, in relation to the time of maximal PGF_2α release. Both steroid receptors populations and COX‐2 expression were similar between horns. Meanwhile, OR expression was higher in the right than in the left uterine horn. In summary, this study showed that the loss of endometrium sensitivity to progesterone by days 8–10 post‐induction of ovulation and the concomitant increase of COX‐2 expression could play a key role in the mechanism of luteolysis and somehow be related to the short corpus luteum lifespan of llamas.  相似文献   

Decadal (2003–2013) changes in liana diversity,abundance and aboveground biomass in four inland tropical dry evergreen forest sites of peninsular India     

Elumalai Pandian  Narayanaswamy Parthasarathy 《林业研究》2016,27(1):133-146

In 2013, we re-inventoried all lianas(C1 cm diameter measured at 1.3 m from the rooting point) in four1-ha permanent plots distributed one each in four sites of inland tropical dry evergreen forest on the Coromandel Coast(Pudukottai district) of peninsular India, established in 2003. Among the four sites, Shanmuganathapuram(SP)and Araiyapatti(AP) were much disturbed and the other two sites(Karisakkadu—KR and Maramadakki—MM)were moderately disturbed. We inventoried a total of 3425 lianas representing 37 species of 33 genera and 22 families.Over a decade(2003–2013) liana species richness increased at two sites(MM and SP) and no changes occurred at the other two sites. Liana abundance increased by 210, 211, 164 and 162 individuals at sites AP, KR, MM and SP, respectively, and basal area increased(from 1.09 to1.76 m2 at AP, 0.67 to 0.86 m2 at KR, 1.68 to 2.06 m2 at MM, and from 0.44 to 1.06 m2 at SP). Over a 10-year period, three species(Abrus precatorius, Canavalia virosa,and Cocculus hirsutus) were lost and five species(Gloriosa superba, Ampelocissus tomentosa, Capparis sepiaria,Aganosma cymosa and Tiliacora acuminata) were newly added. Total aboveground biomass increased by 18.5, 0.74,3.6 and 9.5 Mg ha-1, respectively, at sites AP, KR, MM and SP.  相似文献   

Evaluation of low-molecular-weight heparin for the prevention of equine laminitis after colic surgery     

Geoffroy de la Rebière de Pouyade  DVM  MSc  ; Sigrid Grulke  DVM  PhD  DECVS  ; Johann Detilleux  DVM  MSc  PhD  DECVPH  ; Alexandra Salciccia  DVM  MSc  ; Denis R. Verwilghen  DVM  MSc  ; Isabelle Caudron  DVM  PhD  DECVS  ; Monika Gangl  MV  MSc  DECVS    Didier D.A. Serteyn  DVM  PhD  DECVA 《Journal of Veterinary Emergency and Critical Care》2009,19(1):113-119

Objectives – The aim of this study is to describe the prevalence of postoperative laminitis in colic cases and to determine if low-molecular-weight heparin (LMWH) is effective in preventing this complication.
Design – Retrospective clinical study.
Animals – Client-owned horses.
Interventions – SC administration of enoxaparin during the postoperative period.
Measurements and Main Results – Medical records of 360 horses undergoing surgery for colic and surviving at least 3 days were evaluated. Fifty-six horses admitted before 1995 did not receive LMWH (control group) and 304 admitted after 1995 received LMWH as a prophylaxis for laminitis (treatment group). Three grades of severity were defined for laminitis. Prevalence and severity of laminitis were compared between the 2 groups. Several parameters recorded on admission (sex, age, breed, site and nature of the disease, heart rate, PCV, gravity score, and shock score) and the administration of LMWH were tested as risk factors in the development of laminitis in a logistic regression procedure. Prevalence and grade of laminitis were significantly lower in the treatment group. Only the absence of LMWH was recognized as a significant risk factor in the logistic regression model.
Conclusions – The administration of LMWH appears to be effective in the prophylaxis of laminitis following colic surgery and may be useful in the postoperative management of these horses.  相似文献