An evaluation of an oral formulation of moxidectin against selected anthelmintic-resistant and -susceptible strains of nematodes in lambs     

Bisset SA  Vlassoff A  McMurtry LW  Elliott DC  Cobb RM  Kieran PJ  Wood IB 《New Zealand veterinary journal》1992,40(3):97-100

The efficacy of an oral formulation of the newly developed parasiticide, moxidectin, was tested against benzimidazole-resistant Haemonchus contortus, Trichostrongylus colubriformis, and Nematodirus spathiger, levamisole-resistant Ostertagia circumcincta, and susceptible Cooperia curticei infections in weaned lambs. Thirty-two lambs were experimentally infected with mixed doses of the above strains of nematodes. They were allocated into four treatment groups by stratified randomisation using liveweights and faecal egg counts 28 days later. One group received moxidectin at 0.2 mg/kg liveweight, one group oxfendazole at 4.5 mg/kg liveweight, one group levamisole at 7.5 mg/kg liveweight and the last group remained untreated as the control. Worm burdens in the lambs at slaughter 10 days after oral treatment confirmed the resistance status of the nematode strains used, and showed that moxidectin had a greater than 99.9% efficacy (p<0.01) against all of them. No adverse effects due to treatment with moxidectin were observed in any of the animals.  相似文献   

Key Factors Affecting Reproductive Success of Thoroughbred Mares and Stallions on a Commercial Stud Farm          下载免费PDF全文

EA Lane  MLJ Bijnen  M Osborne  SJ More  ISF Henderson  P Duffy  MA Crowe 《Reproduction in domestic animals》2016,51(2):181-187

To evaluate factors contributing to fertility of thoroughbred mares, data from 3743 oestrous periods of 2385 mares were collected on a large thoroughbred farm in Ireland. Fourteen stallions (mean age 8.3 years; range 4–15 years) had bred 2385 mares (mean age 9.4 years; range 3–24 years). Maiden mares accounted for 12%, mares with a foal at foot for 64%, and barren, slipped or rested mares for 24% of the total. The mean pregnancy rate per cycle was 67.8% (68.6% in year 1 and 66.9% in year 2). Backward stepwise multivariable logistic regression analysis was utilized to develop two models to evaluate mare factors, including mare age, reproductive status, month of foaling, dystocia, month of cover, foal heat, cycle number, treatments, walk‐in status and stallion factors including stallion identity, stallion age, shuttle status, time elapsed between covers and high stallion usage on the per cycle pregnancy rate and pregnancy loss. Old age (p < 0.001) and cover within 20 days post‐partum (p < 0.003) were associated with lowered pregnancy rates. High mare age (p < 0.05) and barren, slipped or rested reproductive status (p = 0.05) increased the likelihood of pregnancy loss. Uterine inflammation or infection, if appropriately treated, did not affect fertility. Only high usage of stallions (used more than 21 times in previous week) was associated with lowered (p = 0.009) pregnancy rates. However, shuttle stallions were more likely to have increased (p = 0.035) pregnancy survival, perhaps reflecting a bias in stallion selection. In conclusion, mare age exerted the greatest influence on fertility; nonetheless, thoroughbreds can be effectively managed to achieve high reproductive performance in a commercial setting.  相似文献   

The effects of vaccination of Merino ewes with an attenuated Australian bluetongue virus serotype 23 at different stages of gestation   总被引：1，自引：0，他引：1  

M. FLANAGAN  SJ JOHNSON 《Australian veterinary journal》1995,72(12):455-457

SUMMARY A cell culture attenuated Australian bluetongue virus serotype 23 (BLU23) prototype vaccine was assessed for its effects on pregnant Merino sheep. Seventy-six ewes were vaccinated at 5 different stages of gestation, and the failure to lamb at term was as follows: 35 to 43 days of gestation, 20/36 (56%); 57 to 64 days of gestation, 3/10 (30%); 81 to 88 days of gestation, 3/10 (30%); 109 to 116 days of gestation, 0/10 (0%); 130 to 137 days of gestation, 0/10 (0%). Of 30 ewes vaccinated with a cell culture supernatant fluid control between 35 and 43 days of gestation, 6.7% (2/30) failed to lamb at term. Two ewes vaccinated with BLU23 vaccine between 35 and 43 days of gestation had lambs with hydranencephaly. All other lambs born were clinically normal. Three ewes vaccinated with BLU23 aborted. Two of these were vaccinated between 35 and 43 days of gestation, the 3rd between 81 and 88 days of gestation. Five lambs were born with BLU group antibody. Four of these were from ewes vaccinated between 35 and 43 days of gestation, and 2 of these had hydranencephaly. The fifth was from a ewe vaccinated between 57 and 64 days of gestation. The vaccine did not produce disease in adult sheep, but was a potent cause of early foetal death and to a much lesser extent foetal malformation.  相似文献   

Public involvement in scientific decision-making     

Cobb JC 《Science (New York, N.Y.)》1976,194(4266):674

  相似文献   

Gram-negative Mastitis in Early Lactation May Interfere with Ovarian and Certain Endocrine Functions and Metabolism in Dairy Cows   总被引：1，自引：0，他引：1  

G Huszenicza  S Jánosi  M Kulcsár  P Kóródi  SJ Dieleman  J Bartyik  P Rudas  P Ribiczei-Szabó 《Reproduction in domestic animals》1998,33(3-4):147-153

  相似文献   

A cranial neuropathy associated with multicentric lymphosarcoma in a dog     

S L Hobbs  M A Cobb 《The Veterinary record》1990,127(21):525-526

  相似文献   

ON THE SIGNIFICANCE OF AN EXPERIMENTAL DIFFERENCE,WITH A PROBABILITY TABLE FOR LARGE DEVIATIONS     

Cobb PW 《Science (New York, N.Y.)》1921,54(1392):200-202

  相似文献   

Use of a programmable, activity-sensing, rate-regulating Sacemaker in dog     

M. A. Cobb  J. Nolan  S. E. Brownlie  R. H. Abercromby  A. L. Fussell 《The Journal of small animal practice》1990,31(8):398-400

A multi-programmable, single chamber pulse generator with automatic, activity-sensing rate regulation was successfully implanted into an eight-year-old crossbred dog with symptomatic third-degree atrioventricular heart block. Postoperative Holter monitoring confirmed appropriate activity-related changes in the ventricular rate.  相似文献   

SEGMENTATION IN NEMATODES: OBSERVATIONS BEARING ON THE UNSETTLED QUESTION OF THE RELATIONSHIP OF NEMATODES TO OTHER BRANCHES OF THE ANIMAL KINGDOM     

Cobb NA 《Science (New York, N.Y.)》1917,45(1171):593

  相似文献   

Effect of ice storage upon the free amino acid contents of tails of white shrimp (Penaeus setiferus)     

B F Cobb  C Vanderzant  K Hyder 《Journal of agricultural and food chemistry》1974,22(6):1052-1055

  相似文献