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1.
A six-year-old arabian stallion was admitted to The Ohio State University Veterinary Hospital for evaluation and repair of a comminuted fracture of the second phalanx. The horse developed impaired arterial oxygenation during surgey and pulmonary edema post-operatively. We postulate that impaired arterial oxygenation resulted from atelectasis of the dependent lung during annesthesia, and the pulmonary edema occurred following re-expansion of the atelectatic of the initiating cause of the edema, removal of excess lung water from the alveoli, and restoration of normal arterial oxygenation. The horse was fully recovered within 12 hours of initiation of clinical signs of respiratory compromise. The horse was fully recovered within 12 hours of initiation of clinical signs of respiratory compromise. This report describes re-expansion pulmonary edema due to reperfusion injury in a horse, treatment of the condition, and a possible explanation of the pathogenesis of this pulmonary pathology.  相似文献   
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Severe economic loss due to high mortality and condemnation rates occurred on two commercial broiler facilities. Chickens had moderate-to-severe airsacculitis, pericarditis, perihepatitis, tracheitis, and synovitis. Pasteurella gallinarum was isolated from 16 of 18 pericardia, four of 14 livers, 11 of 16 air sacs, six of seven joints and one of 28 tracheas in pure culture. In addition, Mycoplasma synoviae was isolated from trachea and air sac. Lesions were suggestive of an Escherichia coli septicemia, but E. coli was isolated from only four of 28 tracheas and one of 14 livers in pure culture. A coronavirus was isolated from trachea and lung. Whether this coronavirus represented a vaccine or field strain of infectious bronchitis was not determined. These findings suggested that the severe lesions were due to a concomitant infection with an atypical strain of P. gallinarum.  相似文献   
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A diagnosis of toxic necrotizing cholangiohepatitis was made in approximately 35% of a flock of 23,000 commercial broiler chickens. Affected chickens were small, and had discrete green foci throughout the liver. Seven to twelve days prior to shipping the flock to slaughter, premixes containing oxytetracycline, monensin, and 3-nitro-4-hydroxyphenylarsonic acid had been added to the ration because the birds had wet droppings and were growing slowly. The 3-nitro-4-hydroxyphenylarsonic acid had been inadvertently incorporated at ten times the recommended level. Liver and kidney of affected birds had elevated levels of total arsenic, and special strains demonstrated arsenic in necrotic foci in liver. Histologically there was marked dilation of intrahepatic bile ducts, and patchy necrosis and hyperplasia of the bile duct epithelium. Damage to bile ducts may have been a toxic manifestation of altered metabolism and excretion of the three drugs being fed to birds suffering from intercurrent diarrhea and/or undefined interactions among the drugs.  相似文献   
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Caprine β-mannosidosis, a fatal inherited deficiency of the lysosomal enzyme β-mannosidase, was diagnosed in neonatal female Nubian crossbred twin kids from a small herd near Guelph, Ontario. The kids had been tetraplegic since birth, with whole body tremors, abnormal nystagmus and an intention tremor of the head.  相似文献   
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The root zone water quality model (RZWQM) was developed primarily for water quality research with a generic plant growth module primarily serving as a sink for plant nitrogen and water uptake. In this study, we coupled the CERES-Maize Version 3.5 crop growth model with RZWQM to provide RZWQM users with the option for selecting a more comprehensive plant growth model. In the hybrid model, RZWQM supplied CERES with daily soil water and nitrogen contents, soil temperature, and potential evapotranspiration, in addition to daily weather data. CERES-Maize supplied RZWQM with daily water and nitrogen uptake, and other plant growth variables (e.g., root distribution and leaf area index). The RZWQM-CERES hybrid model was evaluated with two well-documented experimental datasets distributed with DSSAT (Decision Support System for Agrotechnology Transfer) Version 3.5, which had various nitrogen and irrigation treatments. Simulation results were compared to the original DSSAT-CERES-Maize model. Both models used the same plant cultivar coefficients and the same soil parameters as distributed with DSSAT Version 3.5. The hybrid model provided similar maize prediction in terms of yield, biomass and leaf area index, as the DSSAT-CERES model when the same soil and crop parameters were used. No overall differences were found between the two models based on the paired t test, suggesting successful coupling of the two models. The hybrid model offers RZWQM users access to a rigorous new plant growth model and provides CERES-Maize users with a tool to address soil and water quality issues under different cropping systems.  相似文献   
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Twenty-two young cross-bred swine were treated either intravenously or orally with potassium penicillin G. The pharmacokinetics of penicillin G were determined in plasma and tissues. The plasma half-life of penicillin G in swine was found to be 19.45±1.69 min, and the distribution and elimination kinetics were found to fit a classical two-compartment model. The volume of distribution was found to be 0.53±0.12 1/kg, and the body clearance was found to be 19.06±5.06 ml/min/kg which exceeded the effective renal plasma flow of 16.50±2.73 ml/min/kg, suggesting that the drug was eliminated both by tubular excretion and glomerular filtration. The elimination rate constants (Beta) for the major organs were as follows: muscle, 0.00343 min-1; lung, 0.0310 min-1; fat, 0.0394 min-1; and kidney, 0.0213 min-1, which compared favorably with the elimination rate constant found in plasma (0.0320 min-1). These values were found to be significantly similar at the level of P < 0.005 in muscle, spleen and fat, and at a level of P < 0.025 in lung tissue. The data indicates that blood plasma would be a satisfactory body fluid for estimating this drug in tissue.  相似文献   
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