Cancer in nickel-processing workers in new caledonia     

Langer AM  Rohl AN  Fischbein A  Selikoff IJ 《Science (New York, N.Y.)》1982,215(4531):425-426

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Medicine for the poor: a new deal in denver     

Langer E 《Science (New York, N.Y.)》1966,153(3735):508-512

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A Lean Year for New Buildings:Congress Casts Critical Eyeon NASA, PHS Facilities Requests     

Langer E 《Science (New York, N.Y.)》1963,142(3591):471-472

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Civil Defense: Make Haste Slowly Is Watchword of Current Strategy on Fallout Shelter Program     

Langer E 《Science (New York, N.Y.)》1963,141(3578):340-341

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Transmission of Actinobacillus pleuropneumoniae in pigs under field-like conditions: emphasis on tonsillar colonisation and passively acquired colostral antibodies     

Vigre H  Angen Ø  Barfod K  Lavritsen DT  Sørensen V 《Veterinary microbiology》2002,89(2-3):151-159

The objectives of this study were to elucidate at which age tonsillar colonisation by Actinobacillus pleuropneumoniae occurs in pigs and relate this occurrence to the presence of colostral antibodies to A. pleuropneumoniae. The infection patterns were studied in an isolated cohort of pigs, which consisted of the offspring from five sows originating from a conventional pig herd. The sows were transferred to isolated research facilities before farrowing. A. pleuropneumoniae was detected on the tonsils of all sows. After a nursing period of 3 weeks, the pigs were weaned and reared isolated from other pigs until slaughter. The pigs were examined repeatedly for the presence of A. pleuropneumoniae on the tonsils and for antibodies to A. pleuropneumoniae using bacteriological and serological techniques, respectively.A. pleuropneumoniae was detected in the tonsils of one pig as early as 11 days after birth, showing that A. pleuropneumoniae can be transmitted from sow to offspring during a 3-week nursing period. The cumulative proportion of pigs carrying A. pleuropneumoniae in their tonsils increased significantly between the age of 4-12 weeks. This age period corresponded to the age at which the proportion of pigs with detectable levels of colostral antibodies to the different serotypes of A. pleuropneumoniae was declining. Since these two events take place in the same age period, we expect a possible biological association between the level of the passive immunity and the degree of tonsillar colonisation. The median duration of tonsillar colonisation was estimated to approximately 7-8 weeks.  相似文献   

THE FUNDAMENTAL PARTICLES     

Langer RM 《Science (New York, N.Y.)》1932,76(1970):294-295

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Screening for periodontal disease in research dogs - a methodology study     

Hanne E Kortegaard  Thomas Eriksen  Vibeke Baelum 《Acta veterinaria Scandinavica》2014,56(1)

Background

It has been shown that the prevalence of both clinical attachment loss (CAL) ≥1 mm and pocket probing depth (PPD) ≥4 mm is relatively high even in younger dogs, but also that only a minority of the dogs have such clinical signs of periodontal disease (PD) in more than a few teeth. Hence, a minority of dogs carry the major PD burden. These epidemiological features suggest that screening for PD in larger groups of dogs, allowing for rapid assessment of treatment planning, or for the selection of dogs with or without PD prior to be included in experimental trials, should be possible. CAL is the central variable in assessing PD extent and severity while PPD is the central variable used in treatment planning which make these two variables obvious in a screening protocol with the dual aim of disease identification and treatment planning. The main purpose of the present study in 98 laboratory Beagle dogs was to construct a fast, simple and accurate screening tool, which is highly sensitive for the identification of dogs with PD.

Results

Examination of the maxillary P4, P3, P2, I1 and C would, in this population, result in the identification of 85.5% of all dogs and 96% of all teeth positive for CAL ≥1 mm, and 58.9% of all dogs and 82.1% of all teeth positive for PD ≥4 mm.Examination of tooth pairs, all C’s, maxillary I2, M2 and the mandibular P4 would, in this population result in identification of 92.9% of all dogs and 97.3% of all teeth positive for PD ≥4 mm, and 65.5% of all dogs and 83.2% of all teeth positive for CAL ≥1 mm. The results presented here only pertain to the present study population.

Conclusions

This screening protocol is suitable for examination of larger groups of laboratory Beagle dogs for PD and our findings indicate that diseased dogs are identified with a high degree of sensitivity. Before this screening can be used in clinical practice, it has to be validated in breeds other than Beagle dogs and in populations with larger age variation.  相似文献   

Use of dietary supplements in Denmark is associated with health and former smoking     

Knudsen VK  Rasmussen LB  Haraldsdóttir J  Ovesen L  Bülow I  Knudsen N  Jørgensen T  Laurberg P  Perrild H 《Public health nutrition》2002,5(3):463-468

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Induction and assessment of morpho-biochemical mutants in Artemisia pallens Bess.     

Kanti Rekha  Anima Langer 《Genetic Resources and Crop Evolution》2007,54(2):437-443

Artemisia pallens Bess. is a low volume and high value essential oil plant used in perfumery, cosmetic and flavouring industries. On account of the failure of conventional procedures to induce variability in species, mutation techniques have been tried in our experiments. Dry and viable seeds (moisture content 8%) of homozygous pure breeding lines were subjected to 150–500 Gy doses of gamma rays and 0.01–0.1% ethyl methane sulphonate (EMS) for 8 h. Desirable qualitative mutants were recovered from segregating M₂ generation (4,283 plants scored) raised as single plant progenies. The spectrum of morphological mutants included late and early flowering types; bushy and high yielding types; tall and more capitula-producing types and high oil and high davanone yielding types. These were raised through M₃ families to evaluate stability and transmission of mutant characters. As such out of 15 different types selected in M₂, only 11 types bred true to their characteristic variability. Based on their performance, the mutants were characterised depending upon their distinguishing features. Davanone, the main component of oil showed the maximum increase (64.22% against 54.64% in control) in mutant ‘S–5’ recovered from exposure with 250 Gy γ-rays. Mutant ‘E-6’ was economically most viable having increased oil biosynthesis (0.36% against 0.22% in control) and hence yields higher oil per unit area than the parental control (isolated from 0.05% EMS treatment).  相似文献   

Clonal and genetic variation in three collembolan species revealed by isozymes and randomly amplified polymorphic DNA     

Vibeke Simonsen  Grothe Christensen Pia 《Pedobiologia》2001,45(2):161

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