Cutaneous leiomyosarcoma with visceral metastases in a White Carneau pigeon and literature review     

Niora J. Fabian  Michael Y. Esmail  Lauren Richey  Sureshkumar Muthupalani  Jennifer L. Haupt  Joanna Joy  Sebastian E. Carrasco 《Journal of veterinary diagnostic investigation》2021,33(3):582

Cutaneous leiomyosarcomas are malignant mesenchymal tumors of smooth muscle origin and are reported occasionally in avian species. A 14-y-old male laboratory White Carneau pigeon (Columba livia) was presented for surgical excision of a cervical soft tissue mass. Ultrasonography with color flow Doppler imaging revealed multiple cavitations of mixed echogenicity within the mass and vascularization. Histologically, the dermis and subcutis were expanded by a densely cellular multinodular mass comprised of fusiform cells forming haphazardly arranged broad streams and short interwoven bundles, often surrounding blood vessels and variably sized cavitations. Neoplastic cells were strongly immunopositive for desmin and α–smooth muscle actin, and negative for pancytokeratin, S100, and von Willebrand factor. Based on histopathology and IHC findings, the cutaneous mass was diagnosed as leiomyosarcoma (LMS). The pigeon died 312 d post-operatively. Postmortem examination revealed masses infiltrating the left and right pulmonary airways and one hepatic nodule, but no regrowth at the surgical site. Histologic and IHC evaluation of the pulmonary and hepatic masses were consistent with LMS, representing metastatic foci from the primary cutaneous LMS. Our case highlights the malignant behavior and histomorphologic features of cutaneous LMS in an avian species.  相似文献   

Use of Aloe vera gel coating preserves the functional properties of table grapes     

Serrano M  Valverde JM  Guillén F  Castillo S  Martínez-Romero D  Valero D 《Journal of agricultural and food chemistry》2006,54(11):3882-3886

Table grapes (Vitis vinifera L. cv. Crimson Seedless) were coated with Aloe vera gel according to our developed patent (SP Patent P200302937) and then stored for 35 days at 1 degrees C, and the subsequent shelf life (SL) was monitored at 20 degrees C. Uncoated clusters showed a rapid loss of functional compounds, such as total phenolics and ascorbic acid. These changes were accompanied by reduction of the total antioxidant activity (TAA) and increases in total anthocyanins, showing an accelerated ripening process. On the contrary, table grapes coated with Aloe vera gel significantly delayed the above changes, such as the retention of ascorbic acid during cold storage or SL. Consequently, Aloe vera gel coating, a simple and noncontaminating treatment, maintained the functional properties during postharvest storage of table grapes.  相似文献   

Effect of Fucoidan on the Mitochondrial Membrane Potential (ΔΨm) of Leukocytes from Patients with Active COVID-19 and Subjects That Recovered from SARS-CoV-2 Infection     

Karina Janice Guadalupe Díaz-Resendiz  Carlos Eduardo Covantes-Rosales  Alma Betsaida Benítez-Trinidad  Migdalia Sarahy Navidad-Murrieta  Francisco Fabian Razura-Carmona  Christian Daniel Carrillo-Cruz  Edwin Jaime Frias-Delgadillo  Daniela Alejandra Prez-Díaz  Matxil Violeta Díaz-Benavides  Mercedes Zambrano-Soria  Guadalupe Herminia Ventura-Ramn  Aurelio Romero-Castro  David Alam-Escamilla  Manuel Ivn Girn-Prez 《Marine drugs》2022,20(2)

Fucoidan is a polysaccharide obtained from marine brown algae, with anti-inflammatory, anti-viral, and immune-enhancing properties, thus, fucoidan may be used as an alternative treatment (complementary to prescribed medical therapy) for COVID-19 recovery. This work aimed to determine the ex-vivo effects of treatment with fucoidan (20 µg/mL) on mitochondrial membrane potential (ΔΨm, using a cationic cyanine dye, 3,3′-dihexyloxacarbocyanine iodide (DiOC₆(3)) on human peripheral blood mononuclear cells (HPBMC) isolated from healthy control (HC) subjects, COVID-19 patients (C-19), and subjects that recently recovered from COVID-19 (R1, 40 ± 13 days after infection). In addition, ex-vivo treatment with fucoidan (20 and 50 µg/mL) was evaluated on ΔΨm loss induced by carbonyl cyanide 3-chlorophenylhydrazone (CCCP, 150 µM) in HPBMC isolated from healthy subjects (H) and recovered subjects at 11 months post-COVID-19 (R2, 335 ± 20 days after infection). Data indicate that SARS-CoV-2 infection induces HPBMC loss of ΔΨm, even 11 months after infection, however, fucoidan promotes recovery of ΔΨm in PBMCs from COVID-19 recovered subjects. Therefore, fucoidan may be a potential treatment to diminish long-term sequelae from COVID-19, using mitochondria as a therapeutic target for the recovery of cellular homeostasis.  相似文献   

Specialized receptive fields of the cat's retina     

J Stone  M Fabian 《Science (New York, N.Y.)》1966,152(726):1277-1279

Three new types of receptive field have been found in the cat's retina. The responses of these fields to flashing lights and moving objects suggest that the manner in which they code visual information may be quite different from that of the center-surround fields described in previous studies. These "specialized" fields were all found in the area centralis. A definite functional difference, corresponding to the known anatomical difference, between this region and the rest of the retina, is suggested.  相似文献   

Degree of amino acid restrictions during the grower phase and compensatory growth in pigs selected for lean growth efficiency     

Fabian J  Chiba LI  Kuhlers DL  Frobish LT  Nadarajah K  Kerth CR  McElhenney WH  Lewis AJ 《Journal of animal science》2002,80(10):2610-2618

A total of 32 select line (SL) and 32 control line (CL) Duroc pigs were used in two trials to determine the effect of dietary amino acid contents during the grower (G) phase and selection for lean growth efficiency on growth performance, carcass traits, and meat quality. In each trial, pigs weighing 20 kg were assigned to 16 pens with two gilts or two castrated males per pen, and pens were randomly assigned within the genetic line to corn-soybean meal G diets formulated to contain 5.0, 7.0, 9.0, or 11.0 g lysine/kg. After 50 kg, all pigs were fed common finisher 1 (F1) and finisher 2 (F2) diets. Pigs were allowed ad libitum access to feed and water. After the initial statistical analyses, the data sets from the two trials were combined. During the G phase, pigs consumed less feed [linear (Ln), P < 0.001] and more lysine (Ln, P < 0.001), grew faster (Ln, P < 0.05) but utilized feed more and lysine less efficiently (Ln, P < 0.001) for weight gain as the amino acid content of G diets increased. Increasing dietary amino acids resulted in less ultrasound backfat (Ln, P < 0.001) and more serum urea nitrogen [Ln, P < 0.001; quadratic (Qd), P < 0.01] at the end of the G phase. Pigs grew more slowly during the F1 (Ln, P < 0.01 and Qd, P = 0.05) and F2 (Ln, P = 0.07) phases and utilized feed and lysine less efficiently (Ln, P < 0.05) for weight gain during the F1 phase as the amino acid content of G diets increased. The grower diet had no effect on overall weight gain and feed efficiency, carcass traits, or meat quality scores. The efficiency of lysine utilization for overall weight gain (Ln, P < 0.001) and lean accretion (Ln, P < 0.05) improved as the amino acid content of G diets decreased. The SL pigs grew faster (P < 0.05) and had less (P < 0.001) ultrasound backfat throughout the study compared with the CL pigs. The SL pigs had less 10th rib backfat (P < 0.001) and tended to have larger longissimus muscle area (P = 0.09) than the CL pigs, which were reflected in greater rate (P < 0.001) and efficiency (P < 0.05) of lean accretion. Marbling (P < 0.05) and meat color (P = 0.07) scores were lower in the SL pigs. No grower diet x genotype interactions were observed in response criteria of interest. The results indicate that pigs subjected to dietary amino acid restrictions during the G phase (as low as 5.0 g lysine/kg) compensated completely in terms of growth rate and body composition regardless of the genotype. Compensatory growth can have a positive impact not only on the overall efficiency of pig production but also on the environment by reducing excretion of unused nutrients.  相似文献   

Corrigendum to “Individual tree height increment model for managed even-aged stands of ponderosa pine throughout the western United States using linear mixed effects models” [Forest Ecol. Manage. 221 (2006) 147–154]     

Fabian C.C. Uzoh  William W. Oliver 《Forest Ecology and Management》2007

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Klima und Wald—Perspektiven für die Zukunft     

P. Fabian 《European Journal of Forest Research》1991,110(1):286-304

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Determination of a common forest life cycle assessment method for biodiversity evaluation   总被引：1，自引：0，他引：1  

Susanne Winter  Fabian Brambach 《Forest Ecology and Management》2011,262(12):2120-2132

Forest biodiversity is highly linked with the occurrence of certain forest development phases (fdp) within the forest life cycle. Generally, the disintegration phase provides the highest biodiversity. The objective of the study was to test different existing forest life cycle assessment approaches aiming at developing a common reliable fdp assessment method. We tested and compared three approaches to record fdp in beech, mixed beech and spruce forests, in managed and unmanaged forests, and in four different plot sizes ranging from 125 to 2000 m². The main results of the fdp comparison are as follows:

(1)

In approximately two thirds of the cases the three considered methods did not yield a corresponding fdp record.

(2)

Generally, the larger the plot sizes, the larger the average fdp deviation in forest reserves.

(3)

The fdp deviation is stronger in beech or spruce dominated forest reserves than in mixed beech forest reserves.

(4)

Plots of 500 m² show most distinct numbers of microhabitats corresponding to the fdp sequence within the forest life cycle.

(5)

Furthermore, the managed forests mostly show lower fdp deviation than the forest reserves.

One approach resulted in the most differentiated portrayal of the studied forest structures compared to the other two as shown by the facts that, (a) the studied forests are seen to be divided up into more fdp than when applying the other two methods, and that (b) the dominant fdp changed depending on the forest community and plot size reflecting different growth conditions and probabilities to meet large dimensioned trees during records, respectively, and (c) considering the distribution of microhabitats which are crucial for xylobiontic (saproxylic) organisms, this approach resulted in the assumed biodiversity patterns with increasing microhabitat numbers up to the disintegration phase thus it was used as a basis for the creation of an optimized fdp assessment method as a tool for common and standardized use in forest ecology and biodiversity research.  相似文献   

Pathogens as drivers of population declines: The importance of systematic monitoring in great apes and other threatened mammals     

Fabian H. Leendertz  Georg Pauli  Wayne Boardman  Heinz Ellerbrok  Sandra Junglen  Boesch Christophe 《Biological conservation》2006,131(2):325-337

Until recently, the focus of great ape behavioural and ecological research has been distinct from the focus of scientists working in medical and veterinary sciences. More scientists are calling for a connection between medical and field research due to recent disease outbreaks in great apes, including Ebola, and indications of cross-transmission of Ebola and other viruses between primates and humans. A major limitation to progress is the lack of information on infectious diseases and their transmission in wild primates. Here, we present examples of successful pathogen detection in wild great apes and describe approaches and techniques that can be used in the field, focusing in particular on investigation of deaths and non-invasive sample collection. This interdisciplinary approach is providing new insights to infectious diseases of great apes and is helping to protect the health of great ape populations. This framework can also be applied to other mammals under threat from infectious diseases, including African wild dogs, seals and Tasmanian devils. In addition to providing benefits for great ape conservation, research that integrates infectious disease with primate ecology provides insights to emerging diseases in humans and the role of disease in primate evolution.  相似文献   

Structure of the polycrystalline zeolite catalyst IM-5 solved by enhanced charge flipping     

Baerlocher C  Gramm F  Massüger L  McCusker LB  He Z  Hovmöller S  Zou X 《Science (New York, N.Y.)》2007,315(5815):1113-1116

Despite substantial advances in crystal structure determination methodology for polycrystalline materials, some problems have remained intractable. A case in point is the zeolite catalyst IM-5, whose structure has eluded determination for almost 10 years. Here we present a charge-flipping structure-solution algorithm, extended to facilitate the combined use of powder diffraction and electron microscopy data. With this algorithm, we have elucidated the complex structure of IM-5, with 24 topologically distinct silicon atoms and an unusual two-dimensional medium-pore channel system. This powerful approach to structure solution can be applied without modification to any type of polycrystalline material (e.g., catalysts, ceramics, pharmaceuticals, complex metal alloys) and is therefore pertinent to a diverse range of scientific disciplines.  相似文献