Phaseolus vulgaris L. Leaves Increase Short-Chain Fatty Acid (SCFA) Production,Ameliorating Early Metabolic Alterations     

Becerril-Campos  Adriana Araceli  Ocampo-Anguiano  Perla Viridiana  Mondragón-Jacobo  Candelario  Escobar-García  Konisgmar  Camacho-Barrón  Mariela  Anaya-Loyola  Miriam Aracely  Feregrino-Perez  Ana Angélica  García-Gasca  Teresa  Ahumada-Solórzano  Santiaga Marisela 《Plant foods for human nutrition (Dordrecht, Netherlands)》2022,77(3):421-426

Plant Foods for Human Nutrition - High-fat/high-fructose diets promote early metabolic disorders in weight and lipid and glucose metabolism. Bioactive compounds such as polyphenols and fiber...  相似文献   

A Non-digestible Fraction of the Common Bean (Phaseolus vulgaris L.) Induces Cell Cycle Arrest and Apoptosis During Early Carcinogenesis     

Ana Angelica Feregrino-Perez  Carmen Piñol-Felis  Xavier Gomez-Arbones  Ramón G. Guevara-González  Rocio Campos-Vega  Jorge Acosta-Gallegos  Guadalupe Loarca-Piña 《Plant foods for human nutrition (Dordrecht, Netherlands)》2014,69(3):248-254

We have previously demonstrated that the non-digestible fraction (NDF) from common cooked beans (P. vulgaris L., cv Negro 8025) inhibits azoxymethane (AOM)-induced colon cancer and influences the expression of genes involved in the induction of apoptosis and cell cycle arrest through the action of butyrate. The objective of this study was to identify cell cycle alterations and morphological changes induced by treatment with AOM and to examine the formation of colonic aberrant crypt foci (ACF) in male Sprague Dawley rats fed with these beans. Rats were fed control diets upon arrival and were randomly placed into four groups after one week of acclimatization: control, NDF (intragastric administration), NDF?+?AOM and AOM. Rats treated with NDF?+?AOM exhibited a significantly lower number of total colonic ACF with a notable increase in the number of cells present in the G₁ phase (83.14 %); a decreased proliferation index was observed in the NDF?+?AOM group when compared to AOM group. NDF?+?AOM also displayed a higher number of apoptotic cells compared to AOM group. NDF of cooked common beans inhibited colon carcinogenesis at an early stage by inducing cell cycle arrest of colon cells and morphological changes linked to apoptosis, thus confirming previous results obtained with gene expression studies.  相似文献