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Veloso Emerson Soares Gonçalves Ivy Nayra Nascimento Arantes Jaqueline Amorim de Abreu Rafael Vitor Santos Cassali Geovanni Dantas Ferreira Enio 《Veterinary research communications》2019,43(2):123-129
Veterinary Research Communications - The epithelial growth factor receptors are transmembrane proteins with an important role in the neoplastic progression of tumors, and in this context, DCIS is... 相似文献
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Bertagnolli AC Soares P van Asch B Amorim A Cirnes L Máximo V Cassali GD 《Veterinary journal (London, England : 1997)》2009,182(2):269-274
The aim of this study was to investigate if mutations in the mitochondrial DNA (mtDNA) D-loop fragment control region of canine mammary mixed tumours could be used as clonal markers that identified the cell population of origin. Ten benign mixed mammary tumours and nine carcinomas arising from benign mixed tumours were microdissected and DNA from epithelial and mesenchymal tumour cells and from normal mammary tissue was examined for sequence variations in a fragment of the hypervariable control region.Identical sequence variants in both the epithelial and mesenchymal components (as well as in the corresponding normal tissue) were found in 80% of the benign mixed tumours and in 89% of the carcinomas arising from benign mixed tumours suggesting a shared clonal origin. The distinctive sequence alterations identified in the epithelial and mesenchymal components of 15.8% of all 19 tumours examined, suggests the possibility that a minority of mammary tumours are polyclonal in origin or that early clonal divergence occurs. Increased mutation within the mtDNA D-loop fragment of mixed tumour components was not observed. 相似文献
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Geovanni Dantas Cassali Lidianne Narducci Monteiro Conrado de Oliveira Gamba Karine Araújo Damasceno Cecília Bonolo de Campos Breno Souza Salgado 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2015,44(3):448-451
This is a report on the cytologic analysis of the mammary papillar discharge in a 7‐year‐old female Doberman dog with an invasive micropapillary carcinoma. Cytologic evaluation of nipple discharge is a well‐known method for the rapid diagnosis of breast cancer in women. However, there is no previous report regarding the use of this technique for assessing mammary tumors in dogs. The aim of this study was to describe the use of mammary papillar discharge cytology for diagnosing a micropapillary carcinoma in a dog. Cytologically, evaluation of the papillar discharge revealed cells arranged in clusters in a papillary pattern or in a morula‐like arrangement, suggesting the diagnosis of a micropapillary carcinoma, which was subsequently confirmed by histopathology. Thus, mammary papillar discharge cytology should be considered as an ancillary method for evaluating mammary diseases in dogs. 相似文献
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Ivones Hernndez-Balmaseda Idania Rodeiro Guerra Ken Declerck Jos Alfredo Herrera Isidrn Claudina Prez-Novo Guy Van Camp Olivier De Wever Kethia Gonzlez Mayrel Labrada Adriana Carr Geovanni Dantas-Cassali Diego Carlos dos Reis Livan Delgado-Roche Roberto Rafael Nuez Ren Delgado-Hernndez Miguel David Fernndez Miriam T. Paz-Lopes Wim Vanden Berghe 《Marine drugs》2021,19(2)
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