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Mai H. ElNaggar Ghada M. Abdelwahab Omnia Kutkat Mohamed GabAllah Mohamed A. Ali Mohamed E. A. El-Metwally Ahmed M. Sayed Usama Ramadan Abdelmohsen Ashraf T. Khalil 《Marine drugs》2022,20(3)
Several natural products recovered from a marine-derived Aspergillus niger were tested for their inhibitory activity against SARS CoV-2 in vitro. Aurasperone A (3) was found to inhibit SARS CoV-2 efficiently (IC50 = 12.25 µM) with comparable activity with the positive control remdesivir (IC50 = 10.11 µM). Aurasperone A exerted minimal cytotoxicity on Vero E6 cells (CC50 = 32.36 mM, SI = 2641.5) and it was found to be much safer than remdesivir (CC50 = 415.22 µM, SI = 41.07). To putatively highlight its molecular target, aurasperone A was subjected to molecular docking against several key-viral protein targets followed by a series of molecular dynamics-based in silico experiments that suggested Mpro to be its primary viral protein target. More potent anti-SARS CoV-2 Mpro inhibitors can be developed according to our findings presented in the present investigation. 相似文献
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In this study, the effect of the methanolic extract of Balanites aegyptiaca fruits (BAE) on adult Toxocara vitulorum was evaluated after incubating the parasites in Ringer solution containing 10, 30, 60, 120 and 240 μg/ml of the methanolic extract, for 24h using light and scanning electron microscopic observations. Differences in response to BAE action were concentration dependent. These changes occurred in definite sequences in response to BAE concentration and were consisted of slightly swelling which became pronounced and so severe, with lips showed wrinkled cuticular surface and deformed sensory papillae on increasing the BAE concentration. The strongest effects were reached with the highest BAE concentration, where disorganization of the cuticle and body musculature was observed. Additionally, the ovicidal effect of BAE, at the previous concentrations, on the development of T. vitulorum eggs was examined after 12h exposure. The inhibitory activity of BAE on egg development was concentration dependent and the highest value reached to 100% with the concentration of 240 μg/ml. These results were compared with those observed in the worm cuticle and eggs following incubation in albendazole, as it was a broad-spectrum nematodicidal compound with well-known ovicidal activity. 相似文献
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The objective of this study was to investigate the dietary effect of vitamin C in amelioration some of studied alterations induced by fenitrothion in Nile tilapia (Oreochromis niloticus). Nile tilapia was exposed to sub-lethal concentration of fenitrothion 0.04 mg/l (96 h LC50 value was 0.8 mg/l), and basal diet was supplemented with two different dose of vitamin C (500 and 1200 mg/kg B wt/day) for 30 days. Vitamin C supplemented groups showed significant decrease in plasma cortisol and glucose level, enzymes activity of liver and gills (catalase, glutathione-S-transferase and superoxide dismutase) and % of tail DNA damage compared to exposed group. Moreover, fish revealed significant increase in total plasma protein, albumin, globulin and A/G ratio. High dose of vitamin C dietary supplementation (1200 mg/kg B wt/day) returns these parameters to its normal levels with no significant difference compared to non exposed control group. These results indicated that incorporation of high dose of vitamin C (1200 mg) in aqua feed for 30 days could be potentially less expensive and effective in reducing the alterations induced by fenitrothion in Nile tilapia. 相似文献
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Noha SAYED Ikue MURATA Osama ABDALLA Omnia KILANY Amina DESSOUKI Kazuaki SASAKI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(10):1597
Previous studies reported that diabetes alters the activities of hepatic cytochrome P450 (CYP) enzymes, which, in turn, affects the disposition of some drugs. We herein examined and compared the effects of the combination of dapagliflozin with a low insulin dose, a full dose of insulin alone, and dapagliflozin alone for 3 and 8 weeks on CYP activities in a diabetes type 1 rat model. We induced type 1 diabetes in rats using a single intraperitoneal injection of 60 mg/kg streptozotocin (STZ). Daily treatment with the full dose of insulin alone, dapagliflozin alone, or dapagliflozin in combination with a low dose of insulin was then initiated. STZ-induced rats developed marked hyperglycemia and altered CYP2E activities. Dapagliflozin in combination with a low dose of insulin stabilized hyperglycemia and CYP1A, 2D, 2E and 3A activities. However, dapagliflozin alone did not improve blood glucose levels or CYP activities. These results suggest that the effects of dapagliflozin in combination with a low dose of insulin are similar to those of a full dose of insulin, and stabilize CYP activities in type 1 diabetes. 相似文献
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Clinical signs of heat intolerance (panting) syndrome were observed in Holstein cows in a private farm in Egypt. There were heat intolerance (fever), panting, profuse salivation, hirsutism, lameness and reduced milk production. Blood and serum samples were collected from ten diseased cows and five apparently healthy cows as control. Serological tests confirmed the presence of non-structural protein of foot-and-mouth disease (FMD) infection. There were significant reductions in the total red blood cell count with increased leucocytic and lymphocytic counts in diseased group compared to control. The serum Na, Cl, Ca, Mg, Zn and Fe were significantly reduced but P was increased in diseased animals compared to control. The total protein, albumin, cholesterol and cortisol were significantly reduced but the glucose and malonaldehyde were significantly increased in diseased cows. This was the first report in Egypt to describe the clinical and haemato-biochemical changes in panting syndrome following FMD. 相似文献
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