The effect of erector spinae plane block on perioperative analgesic consumption and complications in dogs undergoing hemilaminectomy surgery: a retrospective cohort study     

Diego A. Portela  Marta Romano  Gustavo A. Zamora  Fernando Garcia-Pereira  Luisito S. Pablo  Bonnie J. Gatson  Alana N. Johnson  Pablo E. Otero 《Veterinary anaesthesia and analgesia》2021,48(1):116-124

ObjectiveTo compare the perioperative use of analgesics and complication rates in dogs administered an erector spinae plane (ESP) block or a traditional opioid-based (OP) treatment as part of analgesic management during hemilaminectomy.Study designRetrospective cohort study.AnimalsMedical records of 114 client-owned dogs.MethodsGeneral data included demographics, duration of procedure, number of laminae fenestrated, perioperative use of steroid and non-steroidal anti-inflammatory drugs. Intra- and postoperative analgesics used in 48 hours and complications rates were compared between groups. Opioid use was expressed in morphine equivalents [ME (mg kg^?1)]. Continuous data were compared using the Mann–Whitney U test and incidence of events with a Fisher's exact tests. Multiple linear regression was used to evaluate association between perioperative ME consumption (dependent variable) with other independent variables. Data are presented as median (range). Differences were considered significant when p < 0.05.ResultsGroup ESP comprised 42 dogs and group OP 72 dogs. No differences were observed in the general data. Intraoperative ME was 0.65 (0.20–3.74) and 0.79 (0.19–5.60) mg kg^?1 in groups ESP and OP, respectively (p = 0.03). Intraoperative infusion of lidocaine was administered intravenously (IV) to 23.8% and 68% of groups ESP and OP, respectively (p < 0.0001). Intraoperative infusion of ketamine was administered IV to 21% and 40% of groups ESP and OP, respectively (p = 0.04). Regression analysis revealed the ESP block as the only independent variable affecting the perioperative ME consumption. Pharmacological intervention to treat cardiovascular complications was administered to 21.4% and 47.2% of dogs in groups ESP and OP, respectively (p = 0.008). There were no differences in postoperative complication rates.Conclusions and clinical relevanceESP block was associated with reduced perioperative opioid consumption, intraoperative adjuvant analgesic use and incidence of pharmacological interventions to treat cardiovascular complications in dogs undergoing hemilaminectomy.  相似文献   

Improving response rates: introducing an anonymous longitudinal survey research protocol for veterinary medical students     

Reisbig AM  Hafen M  White MB  Rush BR 《Journal of veterinary medical education》2007,34(2):194-201

With the Journal of Veterinary Medical Education's recent summer 2005 theme issue on stress, the mental-health concerns of veterinary medical students has been brought to the forefront of the field. Since it is anticipated that research on this topic will continue and that educational institutions may implement changes based upon these results, it is of the utmost importance that this research be of the highest quality. Of particular concern with human-subject inquiries are response rates and confidentiality. In order to accommodate these concerns, an example of a survey research protocol that promotes high response rates and minimizes threats to internal validity influenced by student mistrust in assurances of confidentiality is presented. Specifically, the protocol is designed to ensure anonymity and to preserve the ability to track students longitudinally through the use of anonymous longitudinal identifiers. This protocol was tested with the first-year class of veterinary medical students at Kansas State University in October 2004 and March 2005. The two data collection periods yielded 90% and 76% response rates, respectively. The matching rate of participants, according to the anonymous longitudinal identifiers from Time 1 to Time 2, was 88%.  相似文献   

Beaver eager to be a conduit for "new and novel things". Interview by Susan C. Kahler     

Beaver BV 《Journal of the American Veterinary Medical Association》2003,222(9):1192-1193

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Osteomyelitis of the pelvis caused by Rhodococcus equi in a two-year-old horse     

Clark-Price SC  Rush BR  Gaughan EM  Cox JH 《Journal of the American Veterinary Medical Association》2003,222(7):969-72, 952-3

A 2-year-old female Quarter Horse was evaluated for hind limb lameness, fever (40 degrees C [104 degrees F]), and lethargy of 2 weeks' duration. Hypoproteinemia characterized by hypoalbuminemia and hyperfibrinogenemia was detected. Abdominal ultrasonography revealed thickening of the right dorsal colon wall. Treatment was instituted for putative right dorsal coliis. Lameness evaluation localized signs of pain to the lumbar vertebrae or pelvis. Radiography performed with the horse standing and nuclear scintigraphy revealed no abnormalities. Ventrodorsal pelvic radiography revealed a focal area of bony lysis and proliferation involving the cranial portion of the pubic symphysis. Aspiration yielded purulent exudate containing Rhodococcus equi, which was susceptible to erythromycin. Treatment included surgical debridement of the abscess and oral administration of erythromycin and rifampin. The horse's hind limb lameness completely resolved within 20 days. Infections of the pubic symphysis should be considered when lameness localized to the pelvis is associated with fever and an inflammatory leukogram.  相似文献   

Caesarean sections in cows     

Mulligan G 《The Veterinary record》2003,152(5):148

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Flow cytometry: clinical applications in equine medicine     

Davis EG  Wilkerson MJ  Rush BR 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2002,16(4):404-410

The use of flow cytometry in veterinary diagnostics is becoming a valuable clinical tool with a broad range of applications. Physical characteristics of cells can be determined by the flow cytometer laser and electronics through the measurement of changes in light scatter properties. Other components and functions of cells can be defined through the application of fluorochrome dyes that have an affinity for cellular components. Traditionally, common clinical applications are immunophenotyping of cells of the hematopoietic system with fluorescent-labeled antibodies raised against specific cell surface proteins. Other approaches have been used to elucidate changes in cell function and DNA content. This review is intended to provide the reader with the fundamental uses of flow cytometry. Examples of clinical applications in equine patients include immune-mediated hemolytic anemia, immune-mediated thrombocytopenia (IMT), chronic inflammatory disease, and neoplasia.  相似文献   

Body composition and exercise in racing pigeons     

W Mulligan  J M Maclean  T Preston 《Research in veterinary science》1990,48(3):321-326

Exercise-related changes in body protein 'turnover' and in the absolute amounts of body protein were studied in racing pigeons. Whole body radioactivity was followed in racing and control (limited exercise) birds after protein labelling by the injection of 75Seselenomethionine. Because of re-utilisation of the label this does not give a true picture of body protein turnover but the comparative data suggested an increased turnover in racing compared to control birds. Carcase analysis on a group of pigeons demonstrated a water content for lean body mass of 72.7 per cent +/- 3.54. Lean body mass and exchangeable body potassium were used as indices of total body protein in a group of pigeons participating in an endurance race (15 + hours of flying). The results indicated that no body protein had been used as an energy source. These findings are compatible with the presence in pigeons of a small labile pool or pools of protein. The presence and characteristics of such pools remains to be determined.  相似文献   

Dental acrylics     

T W Mulligan 《Journal of veterinary dentistry》1990,7(1):18-19

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Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor     

Changelian PS  Flanagan ME  Ball DJ  Kent CR  Magnuson KS  Martin WH  Rizzuti BJ  Sawyer PS  Perry BD  Brissette WH  McCurdy SP  Kudlacz EM  Conklyn MJ  Elliott EA  Koslov ER  Fisher MB  Strelevitz TJ  Yoon K  Whipple DA  Sun J  Munchhof MJ  Doty JL  Casavant JM  Blumenkopf TA  Hines M  Brown MF  Lillie BM  Subramanyam C  Shang-Poa C  Milici AJ  Beckius GE  Moyer JD  Su C  Woodworth TG  Gaweco AS  Beals CR  Littman BH  Fisher DA  Smith JF  Zagouras P  Magna HA  Saltarelli MJ  Johnson KS  Nelms LF  Des Etages SG  Hayes LS  Kawabata TT 《Science (New York, N.Y.)》2003,302(5646):875-878

Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target for clinical immunosuppression. We report the development of a specific, orally active inhibitor of JAK3, CP-690,550, that significantly prolonged survival in a murine model of heart transplantation and in cynomolgus monkeys receiving kidney transplants. CP-690,550 treatment was not associated with hypertension, hyperlipidemia, or lymphoproliferative disease. On the basis of these preclinical results, we believe JAK3 blockade by CP-690,550 has potential for therapeutically desirable immunosuppression in human organ transplantation and in other clinical settings.  相似文献   

Signal transduction. A new mediator for an old hormone?     

Hewitt SC  Deroo BJ  Korach KS 《Science (New York, N.Y.)》2005,307(5715):1572-1573

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