Surgical treatment of congenital lobar emphysema in a puppy     

Billet JP  Sharpe A 《The Journal of small animal practice》2002,43(2):84-87

Congenital lobar emphysema was found in a three-month-old male springer spaniel. Clinical signs included coughing, progressive dyspnoea and abnormal lung auscultation. Radiographic examination revealed overinflation and hyperlucency of the right middle lung lobe. Following lung lobectomy, clinical signs resolved and the animal had normal exercise tolerance. Previous case reports are reviewed and discussed in relation to human congenital lobar emphysema.  相似文献   

Efficacy of Postoperative Antimicrobial Use for Clean Orthopedic Implant Surgery in Dogs: A Prospective Randomized Study in 100 Consecutive Cases          下载免费PDF全文

Andrea Pratesi DVM  PhD  CertSAS  DipECVS  Ciara Downes MVB  CertSAS  Thomas W. Maddox BVSc  PhD  CertVDI  DipECVDI 《Veterinary surgery : VS》2015,44(5):653-660

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Report on coccidiostats     

M M Sharpe 《Journal of the Association of Official Analytical Chemists》1974,57(2):316-317

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Cooperation, control, and concession in meerkat groups     

Clutton-Brock TH  Brotherton PN  Russell AF  O'Riain MJ  Gaynor D  Kansky R  Griffin A  Manser M  Sharpe L  McIlrath GM  Small T  Moss A  Monfort S 《Science (New York, N.Y.)》2001,291(5503):478-481

"Limited control" models of reproductive skew in cooperative societies suggest that the frequency of breeding by subordinates is determined by the outcome of power struggles with dominants. In contrast, "optimal skew" models suggest that dominants have full control of subordinate reproduction and allow subordinates to breed only when this serves to retain subordinates' assistance with rearing dominants' own litters. The results of our 7-year field study of cooperative meerkats, Suricata suricatta, support the predictions of limited control models and provide no indication that dominant females grant reproductive concessions to subordinates to retain their assistance with future breeding attempts.  相似文献   

WIDER USE FOR ACADEMY OF SCIENCE PUBLICATIONS THROUGH IMPROVED DISTRIBUTION     

Sharpe CF 《Science (New York, N.Y.)》1940,92(2392):403-405

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Monosodium glutamate: specific brain lesion questioned     

C U Lowe  M R Zavon  J W Olney  L G Sharpe 《Science (New York, N.Y.)》1970,167(920):1016-1017

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Effect of nitrogen in a closed-circle system with low oxygen flows for equine anesthesia     

A Tevik  J Sharpe  A W Nelson  W E Berkley  W V Lumb 《Journal of the American Veterinary Medical Association》1969,154(2):166-170

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Clinical and pathological features of experimental scrapie in Irish Blackface Mountain sheep     

Sharpe A  McElroy M  Bassett H  Sweeney T 《Research in veterinary science》2006,80(1):71-78

There have been no reports of natural scrapie in Irish Blackface Mountain (BM) sheep which account for approximately 16% of the Irish national sheep flock. The aim of this study was to determine if Irish BM sheep had unusual clinical and/or pathological features of scrapie which would account for failure to diagnose the disease in this breed. BM (n=7), Texel (n=3) and Suffolk sheep (n=1) of scrapie-susceptible PrP genotypes (ARQ/ARQ and VRQ/ARQ) were orally challenged with scrapie-infected brain inoculum. The incubation period, clinical signs, pathology and distribution of disease specific prion protein (PrP(d)) in scrapie-affected BM sheep were similar to scrapie in the Texel and Suffolk sheep. It was concluded that there was no evidence to suggest that scrapie in BM sheep differs clinicopathologically from scrapie in other breeds of sheep.  相似文献   

Structure of an intermediate state in protein folding and aggregation     

Neudecker P  Robustelli P  Cavalli A  Walsh P  Lundström P  Zarrine-Afsar A  Sharpe S  Vendruscolo M  Kay LE 《Science (New York, N.Y.)》2012,336(6079):362-366

Protein-folding intermediates have been implicated in amyloid fibril formation involved in neurodegenerative disorders. However, the structural mechanisms by which intermediates initiate fibrillar aggregation have remained largely elusive. To gain insight, we used relaxation dispersion nuclear magnetic resonance spectroscopy to determine the structure of a low-populated, on-pathway folding intermediate of the A39V/N53P/V55L (A, Ala; V, Val; N, Asn; P, Pro; L, Leu) Fyn SH3 domain. The carboxyl terminus remains disordered in this intermediate, thereby exposing the aggregation-prone amino-terminal β strand. Accordingly, mutants lacking the carboxyl terminus and thus mimicking the intermediate fail to safeguard the folding route and spontaneously form fibrillar aggregates. The structure provides a detailed characterization of the non-native interactions stabilizing an aggregation-prone intermediate under native conditions and insight into how such an intermediate can derail folding and initiate fibrillation.  相似文献   

Risk factors for transmission of foot-and-mouth disease during an outbreak in southern England in 2007     

Ellis-Iversen J  Smith RP  Gibbens JC  Sharpe CE  Dominguez M  Cook AJ 《The Veterinary record》2011,168(5):128

During an outbreak of foot-and-mouth disease (FMD) in southern England in 2007, a case-control study was conducted to identify risk factors for infection and to investigate the relative impact of risk factors on transmission between the infected farms. Seven of the eight case farms in the outbreak and 22 control farms participated. Data were collected via questionnaires and subjected to comparative statistical analysis. Case farms were further classified as primary or secondary according to the likely source of infection during the study. On primary case farms, it was plausible that infection had been introduced directly from the original source. On secondary case farms, FMD infection was more likely to have originated from another infected premises. Calving occurred more frequently on case farms than on control farms during the risk period, and the two primary case farms had a larger proportion of youngstock than the other farms. Secondary case farms (n=5) had a higher composite environmental risk score and a lower biosecurity score than control farms.  相似文献