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Nurilmala Mala Pertiwi Rizsa Mustika Nurhayati Tati Fauzi Shita Batubara Irmanida Ochiai Yoshihiro 《Fisheries Science》2019,85(3):591-599
Fisheries Science - Collagen is one of the biopolymer proteins that may be useful for food and non-food purposes. Recently, even for collagen, it is becoming necessary to meet the requirements of... 相似文献
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In screening experiments for antiacne activity, methanolic and 50% ethanolic extracts of Caesalpinia sappan wood showed the most potent activity out of 28 species of plants extracts. These extracts showed inhibition of Propionibacterium acnes growth, lipase inhibitory activity, and antioxidant activity. In order to isolate the active compound from C. sappan, separation of the extract components was performed by column chromatography and preparative high-performance liquid chromatography
(HPLC). Brazilin, protosappanin A, and sappanone B were isolated from methanolic extracts. Brazilin showed better antibacterial
activity [minimum inhibitory concentration (MIC) = minimum bactericidal concentration (MBC) = 0.50 mg/ml] than protosappanin
A (MIC = MBC = 1.00 mg/ml) and sappanone B (MIC = MBC > 2.00 mg/ml). The 50% inhibitory concentration (IC50) for lipase inhibition was lowest for brazilin (6 μM), which showed strong inhibition compared with protosappanin A (100
μM) and chloramphenicol (677 μM, positive control). The antioxidant activity of brazilin (IC50 8.8 μM) was not significantly different from protosappanin A (9.1 μM) and (+)-catechin (10.2 μM). The antioxidant activity
of brazilin and protosappanin A were higher than sappanone B (IC50 14.5 μM). Brazilin is considered to have suffi ciently potent activity for use as an antiacne agent. 相似文献
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Indonesian medicinal plants were screened as potential sources of antiacne agents. The screening methods were performed using
antibacterial assay against Propionibacterium acnes, lipase inhibitor assay, and antioxidant assay. The results showed that from 40 plant materials extracted with methanol and
50% ethanol in water, Caesalpinia sappan was the best extract based on the combined activities: antibacterial (minimum inhibitory concentration 0.13 mg/ml; minimum
bactericidal concentration 0.25 mg/ml), lipase inhibitory [50% inhibitory concentration (IC50) 120.0 μg/ml], and antioxidative (IC50 6.47 μg/ml). Another prospective extract is Intsia palembanica based on its lipase inhibitory activity (IC50 4.1 μg/ml) and antioxidant activity (IC50 3.87 μg/ml).
Part of this report was presented at the 58th Annual Meeting of the Japan Wood Research Society, Tsukuba, March 2008 相似文献
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Irmanida Batubara Harlinda Kuspradini Ali Mahmoud Muddathir Tohru Mitsunaga 《Journal of Wood Science》2014,60(2):169-174
Potential compounds from Intsia palembanica methanol extracts were isolated. Three isolated compounds as well as 7 reported compounds from Merbau were analyzed for their ability to inhibit the lipase activity of Propionibacterium acnes. Lipase was isolated from P. acnes and used as enzyme for activity analysis. The lipase activity test was performed using the 2,3-dimercapto-1-propanol tributyrate (BALB) method. The results showed that methanol extract and water fraction were active to inhibit lipase activity but n-hexane fraction and EtOAc fraction did not reach 50 % inhibition until 500 μg/ml. EtOAc fraction consisted of flavonoid, naringenin, robinetin, and (+)-epirobidanol accelerated the lipase activity. The other 7 compounds showed inhibitory activity of lipase in a concentration-dependent manner. In conclusion, fustin is the most active compound to inhibit the P. acnes lipase activity. 相似文献
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