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It is important to understand seasonal heavy metal accumulation in different parts of plants in order to develop the best phytoremediation practices for con-taminated soils. For this purpose we exposed...  相似文献   
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Background:

Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran.

Methods:

Blood samples were collected from 200 CAD patients and 110 healthy individuals with no CAD. The association of two SNPs with CAD was evaluated by PCR and restriction fragment length polymorphism.

Results:

Chi-square test showed no association between rs1333040 SNP and CAD (X2: 4.66, df: 2, P=0.09). Also, there was no association between rs1004638 SNP and CAD (X2: 0.27, df: 2, P=0.88).

Conclusion:

No association was observed between rs1333040 and rs1004638 SNPs in the 9P21 region and CAD in Southwest of Iran. Key Words: Coronary artery disease, Single nucleotide polymorphisms, Genetic association study, Iran  相似文献   
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In previous study, the effects of synthesized chitosan/zeolite and nanochitosan/zeolite composites on rainbow trout growth, digestive enzyme activities and some biochemical parameters were shown. In this study, the effects of experimental diets based on the previous study on the rainbow trout intestinal histology and stereology were assessed: control diet (no zeolite and composite), T1 diet (14.28 g/kg zeolite), T2 diet (0.05 g/kg chitosan included in zeolite), T3 diet (0.5 g/kg chitosan included in zeolite), T4 diet (5 g/kg chitosan included in zeolite), T5 diet (0.05 g/kg nanochitosan included in zeolite), T6 diet (0.5 g/kg nanochitosan included in zeolite), T7 diet (5 g/kg nanochitosan included in zeolite). The experiment was conducted for 60 days. Results showed that supplemental diets did not have side effect on the normal structure of intestinal segments but administration of T1 and T4 diets had slight negative effects on structural maintenance in the middle part of intestine. Acidic mucin producing goblet cell percentage was also higher in nanocomposites‐administrated groups in comparison with the control group. Enhanced villus height, density and finally absorption surface area in different parts of rainbow trout intestine were mainly shown in T7 group. Meanwhile, higher thickness of tunica mascularis in different regions were noted in treatment groups especially in T7 group. The number of intraepithelial mononuclear leukocytes in fish intestine received treatment diets was also higher than control group. In conclusion, nanochitosan/zeolite composites in comparison with zeolite and chitosan/zeolite composites were more effective to improve histological structure of rainbow trout intestine.  相似文献   
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The aim of this study was to investigate the association between mental disorder and back pain among postmenopausal Iranian women. Three thousand six hundred and fifty five postmenopausal women were interviewed in the second National Health Survey (2nd NHS) in the year 2000, in Iran. Of whom, 2953 women were included in this study. Back pain (BKP) was considered as dependent variable and mental disorder as independent variable. Factors like age, Body Mass Index (BMI), residential area, employment, literacy, smoking habit, marital status and spinal fractures were considered as confounders. Logistic regression models have been applied for data analysis. The BKP prevalence was 40.1% and the prevalence of mental disorder was 44.3%. After adjustment for confounders, mental disorder was positively associated with BKP, OR (CI): 1.615 (1.36, 1.91). This study confirmed that BKP and mental disorder are common problems and these two factors are associated amongst postmenopausal women. Further longitudinal studies are recommended to specify casual inferences.  相似文献   
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Pacific white shrimp (Litopenaeus vannamei) is an important species in aquaculture worldwide. Post-mortem changes during cold storage reduce the quality of shrimp and shorten its shelf life. Cold plasma (CP) was applied for 45, 90, and 150s as T1, T2, and T3, respectively, to fresh harvested shrimp. The biochemical parameters and melanosis were analyzed in comparison to metabisulphite treated (TM) and control during 12 days of refrigerated storage. The results highlighted lower rate of increase in pH, total volatile base nitrogen (TVB-N) content, thiobarbituric acid reactive substances (TBARS), free fatty acid (FFA), peroxide value (PV), and fluorescent compounds (FC) in shrimp exposed to CP and metabisulphite compared to control (P < 0.05). Although CP lowered biochemical changes in T1 and T3 shrimp, T2 was the most effective treatment in reducing undesirable changes and improving quality of shrimp. In all storage periods, melanosis was significantly lower in T2, T3, and TM samples. Results demonstrate that CP exposure effectively decreases relative activity of polyphenol oxidase (PPO) enzyme, and prolonging the exposure to CP for 150 s resulted in 50% reduction in enzyme activity. We conclude that application of CP for 90 s was the most efficient circumstance to extend shelf life of white shrimp during cold storage.  相似文献   
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ABSTRACT

Conservation tillage practices have gained interests. A 2-year field study (2014–2015) was conducted to evaluate four N rates (0, 69, 138, and 207 kg N ha?1) effects on irrigated sweet corn (Zea mays L.) grown with or without wheat (Triticum aestivum L.) residue removal and conventional (CT), reduced (RT), or no-tillage (NT) practices near Shiraz, Iran. After 2 years, maximum marketable yield occurred at 156 and 159 kg N ha?1 under CT and NT, respectively, while yield was tended to be increased with increasing N rates under RT. Increasing N rate increased total plant N uptake, shoot, and grain N accumulation. The lowest nitrogen use efficiency (NUE) was obtained under NT, while RT and CT either showed similar effects or RT was superior over CT. Soil total N was greater under CT and residue retention showed 18% and 14% higher N concentration than residue removal in 2014 and 2015, respectively. Soil organic matter was the highest (2.59%) under RT with residue retention and 138 kg N ha?1. Conservation tillage needs more N rather than CT during transition from conventional to conservation agriculture practices, but it is based on the short-term results and evaluation of long-term experiment is highly recommended.  相似文献   
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Background:To study the anticancer activity of Plantago major, we assessed the effect of ethanolic, methanolic and acetonic extracts of this plant on HCT-116, SW-480, and HEK-293 cell lines as control. Methods:The cytotoxic activity, biocompatibility, and toxicity were evaluated by MTT assay, hemolysis, and Artemia salina-LD50 (on mice) tests, respectively. The analysis of the extracts was performed by GC-MS analysis. Results:The results showed that all the extracts had the most antiproliferative properties on the HCT-116 cell line. The P. major root extract was more effective than the aerial parts, and IC50 values for ethanolic, methanolic and acetonic root extracts were 405.59, 470.16, and 82.26 µg/mL, respectively on HCT-116 cell line at 72 h. Hemolysis degree of the ethanolic extract of aerial and root parts were approximately 1% at 400 μg/mL.. Using the ethanolic extracts, the Artemia survived every concentration, and no toxicity was observed. One week after the oral administration of different parts of P. major extracts, none of the mice died, even those were administered 2000 mg/kg. The results of GC/MS analysis showed that P. major extracts contain potential anticancer compounds, such as stearic acid (8.61%) in aerial parts of methanolic extract and 1,2- Benzenedicarboxylic acid, mono(2-ethylhexyl)ester (88.07% and 40.63%) in aerial and root parts of acetonic extract of P. major. Conclusions:Our findings suggest that the P. major is a source of potential compounds with antiproliferative properties. Key Words: Gas chromatography-mass spectrometry, HCT-116 cells, Hemolysis, Lethal dose 50  相似文献   
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