Effects of the plant alkaloid thaliblastine on non-cross-resistant and sensitive human leukemia cells in relation with reversal of acquired anthracycline resistance     

Horvath LE  Konstantinov SM  Ilarionova MV  Todorov DK 《Fitoterapia》2004,75(7-8):712-717

Thaliblastine exhibits dose dependent cytotoxic effect on HL-60, HL-60/DOX, RHE and HD-MY-2 leukemia cells. Additionally, typical for apoptosis oligonucleosomal DNA fragmentation could be detected in leukemia cells treated with thaliblastine. Moreover, an MDR-phenotype reversing effect of thaliblastine was also identified.  相似文献   

The effect of gamma irradiation on the MOE of various species   总被引：1，自引：0，他引：1  

Ferenc Divos  Laszlo Bejo 《Wood Science and Technology》2006,40(2):87-93

Gamma irradiation is a simple and effective method to sterilize wood and stop fungal decay. Unfortunately, little is known of the effect of this method on other properties of wood. The purpose of the present study was to establish the relationship between irradiation dosage and the elastic characteristics of wood. The longitudinal and transverse dynamic MOE of five wood species were measured periodically between subsequent irradiation phases. There was a steady decrease in MOE as gamma dosage increased, for all species included. The extent of this decrease was different between the examined species. The experimental data suggests that the MOE of lower density species decreases more sharply than that of higher density ones. Interpolation between the experimental data points shows that the necessary dose for fungal sterilization does not significantly reduce the MOE of the species involved in this study.  相似文献   

Role of brain insulin receptor in control of body weight and reproduction     

Brüning JC  Gautam D  Burks DJ  Gillette J  Schubert M  Orban PC  Klein R  Krone W  Müller-Wieland D  Kahn CR 《Science (New York, N.Y.)》2000,289(5487):2122-2125

Insulin receptors (IRs) and insulin signaling proteins are widely distributed throughout the central nervous system (CNS). To study the physiological role of insulin signaling in the brain, we created mice with a neuron-specific disruption of the IR gene (NIRKO mice). Inactivation of the IR had no impact on brain development or neuronal survival. However, female NIRKO mice showed increased food intake, and both male and female mice developed diet-sensitive obesity with increases in body fat and plasma leptin levels, mild insulin resistance, elevated plasma insulin levels, and hypertriglyceridemia. NIRKO mice also exhibited impaired spermatogenesis and ovarian follicle maturation because of hypothalamic dysregulation of luteinizing hormone. Thus, IR signaling in the CNS plays an important role in regulation of energy disposal, fuel metabolism, and reproduction.  相似文献   

Extracting 3D from motion: differences in human and monkey intraparietal cortex     

Vanduffel W  Fize D  Peuskens H  Denys K  Sunaert S  Todd JT  Orban GA 《Science (New York, N.Y.)》2002,298(5592):413-415

We compared three-dimensional structure-from-motion (3D-SFM) processing in awake monkeys and humans using functional magnetic resonance imaging. Occipital and midlevel extrastriate visual areas showed similar activation by 3D-SFM stimuli in both species. In contrast, intraparietal areas showed significant 3D-SFM activation in humans but not in monkeys. This suggests that human intraparietal cortex contains visuospatial processing areas that are not present in monkeys.  相似文献   

Bovine viral diarrhea (BVD) as the cause of calf mortality among cattle breeding stock in the Wesermarsch district     

H R Frey  H H Onken  B Liess  S Orban  D Timm  W Marquardt  H H Fiedler 《DTW. Deutsche tier?rztliche Wochenschrift》1987,94(3):162-165

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Angewandte un topographische Anatomie der Haustiere          下载免费PDF全文

Laszlo De Roth 《The Canadian veterinary journal. La revue veterinaire canadienne》1976,17(5):135

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Cerebellar hypoplasia and hydranencephaly in cattle after transplacental bovine diarrhea virus infection     

G Trautwein  M Hewicker  B Liess  S Orban  W Peters 《DTW. Deutsche tier?rztliche Wochenschrift》1987,94(10):588-590

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Studies on transplacental transmissibility of a bovine virus diarrhoea (BVD) vaccine virus in cattle. II. Inoculation of pregnant cows without detectable neutralizing antibodies to BVD virus 90-229 days before parturition (51st to 190th day of gestation)   总被引：3，自引：0，他引：3  

B Liess  S Orban  H R Frey  G Trautwein  W Wiefel  H Blindow 《Zentralblatt für Veterin?rmedizin. Reihe B. Journal of veterinary medicine. Series B》1984,31(9):669-681

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Comparison of follicular and oocyte development and reproductive hormone secretion during the ovulatory period in Hungarian native breed, Mangalica, and Landrace gilts     

Rátky J  Brüssow KP  Egerszegi I  Torner H  Schneider F  Solti L  Manabe N 《The Journal of reproduction and development》2005,51(4):427-432

Only a very small amount of physiological data is available about the low fertility (mean litter size is 5.7+/-0.8) of Hungarian native breed, Mangalica (M), sows. The aim of the present paper is to reveal the differences in preovulatory follicle development and intrafollicular oocyte maturation between M and Landrace (L) gilts, with special reference to the peri- and postovulatory secretion and peripheral concentrations of estradiol-17beta (E2), progesterone (P4), and luteinizing hormone (LH). The number of preovulatory follicles was 6.8+/-1.4 and 19.6+/-6.6 in M and L gilts, respectively. A lower degree of cumulus expansion and a lower percentage of mature oocytes (TI/M II) was noted in M. Higher LH and E2 peak levels, a longer E2 to LH peak interval, and lower embryo survival was confirmed. Interestingly, despite the lower number of corpora lutea, a higher peripheral blood level of P4 was shown in M than in L gilts. Both diminished follicular development and protracted oocyte maturation may be involved in low fecundity in M, and the present findings may explain these reproductive phenomena.  相似文献   

Studies on transplacental transmissibility of a bovine virus diarrhoea (BVD) vaccine virus in cattle. III. Occurrence of central nervous system malformations in calves born from vaccinated cows     

G Trautwein  M Hewicker  B Liess  S Orban  E Grunert 《Zentralblatt für Veterin?rmedizin. Reihe B. Journal of veterinary medicine. Series B》1986,33(4):260-268

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