Zoonoses in laboratory animals          下载免费PDF全文

Percy DH 《The Canadian veterinary journal. La revue veterinaire canadienne》1987,28(5):268-269

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Pathogenesis of canine herpesvirus encephalitis   总被引：1，自引：0，他引：1  

D H Percy  J F Munnel  H J Olander  L E Carmichael 《American journal of veterinary research》1970,31(1):145-156

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Pharmacokinetics of tetracycline in the domestic rabbit following intravenous or oral administration.          下载免费PDF全文

D H Percy  W D Black 《Canadian journal of veterinary research》1988,52(1):5-11

Tetracycline hydrochloride was administered to domestic rabbits using a single bolus by the intravenous and oral routes. Pharmacokinetic parameters were determined for intravenous (10 mg/kg) and oral (150 mg/kg) administration. The effect of fasting for 12 h on the drug elimination kinetics after oral administration was evaluated. Tetracycline was added to the drinking water at 800 mg/L or 1600 mg/L. Drug and water intake and serum levels were monitored. Mean serum pharmacokinetic parameters following intravenous administration were; 0 intercept beta curve B (microgram/mL) = 7.5, rate of elimination from body -b (min-1) = 0.0058, half life elimination from body -t 1/2 b (min) = 120.0, wt(kg) = 3.2 determined using combined male and female data. Mean serum pharmacokinetic parameters after oral administration (single bolus) were -B (microgram/mL) = 1.54 (full stomach) and 2.71 (empty stomach), b(min-1) = 0.0037 (full stomach) and 0.0035 (empty stomach), t 1/2 b (min) = 190.3 (full stomach) and 216.2 (empty stomach). Administration of tetracycline in the drinking water produced very low to nondetectable levels of drug in the serum, even at high dosage, and the 1600 mg/L drug concentration was accompanied by a significant drop in water intake. Thus, it is evident that concentrations of tetracycline of up to 1600 mg/L drinking water will not produce levels of antibiotic consistently detectable in the serum.  相似文献   

Retinal dysplasia due to feline panleukopenia virus infection.     

D H Percy  F W Scott  D M Albert 《Journal of the American Veterinary Medical Association》1975,167(10):935-937

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Coronavirus infection in the laboratory rat: immunization trials using attenuated virus replicated in L-2 cells.          下载免费PDF全文

D H Percy  R A Scott 《Canadian journal of veterinary research》1991,55(1):60-66

Sixty-nine specific pathogen-free male Wistar rats approximately eight weeks of age were used to evaluate the efficacy of an attentuated strain of sialodacryoadenitis (SDA) virus in providing protection against infection on subsequent challenge with virulent SDA virus. Fifty-four animals were inoculated intranasally with approximately 10(3.5) median cell culture infectious doses of the 25th passage of SDA virus in L-2 cells. Randomly-selected vaccinated animals were killed in order to evaluate the safety and efficacy of attenuated virus by histopathological examination of the salivary glands, lacrimal glands, and lower respiratory tract, and titration of sera for antibody to SDA virus. At three months and six months postvaccination (pv), animals were selected at random and challenged with virulent SDA virus. Seronegative, age-matched animals were also challenged, and served as controls. In animals examined at six to ten days pv, lesions were absent in submandibular and parotid salivary glands and lacrimal glands, but transient lesions were present in major airways of the lower respiratory tract. In a comparison of the incidence and extent of lesions, and antibody titers in challenged vaccinates and seronegative controls, lesions were minimal or absent in vaccinates compared to challenged naive rats, particularly in animals inoculated at three months pv. In addition, antibody titers in challenged vaccinates were much higher than were postinoculation titers in inoculated controls. In a comparison of lesions in salivary and lacrimal glands in vaccinated and control animals challenged at six months pv, there was a significant reduction in the number of animals without lesions in the vaccinated group (p = less than 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

Experimental pneumonia in rabbits inoculated with strains of Pasteurella multocida.   总被引：2，自引：1，他引：1       下载免费PDF全文

D H Percy  J L Bhasin    S Rosendal 《Canadian journal of veterinary research》1986,50(1):36-41

Domestic rabbits were inoculated with either a 3:A or 3:D serotype of Pasteurella multocida by aerosol, intravenous, or intratracheal inoculation. Different colony forming units of P. multocida were used. Animals which died or were killed after the 14 day observation period were examined macroscopically and microscopically for lesions in the lower respiratory tract. Pneumonic lesions were most consistently produced in rabbits inoculated intratracheally with serotype 3:A. Pulmonary and pleural lesions were observed in some animals inoculated intravenously with serotype 3:A. Lesions were minimal in rabbits inoculated with serotype 3:D. Of the three routes of inoculation evaluated, the intratracheal route appeared to be the best method to produce Pasteurella-associated lesions in the lower respiratory tract.  相似文献   

Some practical considerations of good experimental design     

Percy F. Hunt 《Pest management science》1977,8(4):395-395

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Clinical, cerebrospinal fluid, and histological data from twenty-seven cats with primary inflammatory disease of the central nervous system.   总被引：2，自引：1，他引：1       下载免费PDF全文

J S Rand  J Parent  D Percy    R Jacobs 《The Canadian veterinary journal. La revue veterinaire canadienne》1994,35(2):103-110

The purpose of this report is to present the clinical, cerebrospinal fluid (CSF) and histological data from 27 cats with inflammatory disease of the central nervous system (CNS). The cats were part of a study of 61 cats admitted to two university clinics over an eight-year period because of signs of CNS disease. The most frequent diseases were feline infectious peritonitis (FIP) (12/27) and suspected viral disease other than FIP (10/27). Typical CSF findings in cats with FIP were a protein concentration of greater than 2 g/L (200 mg/dL) and a white cell count of over 100 cells/microL, which consisted predominantly of neutrophils. In contrast, the CSF of cats with suspected viral disease had a protein concentration of less than 1 g/L (100 mg/dL) and a total white cell count of less than 50 cells/microL. In general, cats with FIP or suspected viral disease were less than four years of age. Neurological signs were usually multifocal in cats with FIP, but focal in cats with suspected viral disease. The CSF findings were variable in five other inflammatory diseases represented. Two cats with protozoan infection had normal CSF total cell counts but abnormal differential counts. The CSF findings were invaluable in differentiating FIP from other causes of inflammatory CNS disease.  相似文献   

Experimental sialodacryoadenitis virus infection in athymic CD-1 mice.          下载免费PDF全文

D H Percy  S J Bond  J I MacInnes  J P Desc?teaux 《Canadian journal of veterinary research》1988,52(3):370-374

The purpose of the study was to investigate the susceptibility of nude mice to sialodacryoadenitis virus. Young adult male CD-1 nude mice were inoculated intranasally with virus, killed at 2, 4, 6, 8, 10 and 20 days postinoculation and examined for virus-induced lesions in tissues including respiratory tract. Inoculated and control mice were examined by virus isolation and serology. In a companion study, male Wistar rats were inoculated intranasally with the same inoculum, and examined by histopathology, immunofluorescence microscopy and serology. In virus-inoculated mice, lesions were minimal in the lower respiratory tract, and were absent in other tissues. Virus was isolated from the lower respiratory tract in animals sampled at six or eight days postinoculation. Antiviral antibody was not detected in sera from inoculated and control mice. Virus-associated lesions and antibodies were readily detected in rats following inoculation. Based on this study, there is no evidence that inadvertent exposure to sialodacryoadenitis virus should pose a threat to CD-1 nude mice, and their susceptibility to the disease appears to be similar to that reported in euthymic CD-1 mice.  相似文献   

INFECTION OF CHICKS WITH RECENTLY ISOLATED NEWCASTLE DISEASE VIRUSES OF LOW VIRULENCE   总被引：1，自引：0，他引：1  

E. L. French  M.Sc.  Ph.D.  T. D. St.  George B.V.Sc. Jennifer J.  Percy B.Sc. 《Australian veterinary journal》1967,43(9):404-409

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