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1.
Morteza Zendehdel Keyvan Hasani Vahab Babapour Sepideh Seyedali Mortezaei Yalda Khoshbakht Shahin Hassanpour 《Veterinary research communications》2014,38(1):11-19
The present study was designed to examine the effects of intracerebroventricular (ICV) injection of Dopamine (10, 20 and 40 nmol), L-DOPA (dopamine precursor; 62.5, 125 and 250 nmol), 6-OHDA (dopamine inhibitor; 75, 150 and 300 nmol), SCH 23390 (D1 antagonist; 2.5, 5 and 10 nmol), AMI-193 (D2 antagonist; 2.5, 5 and 10 nmol), NGB2904 (D3 antagonist; 3.2, 6.4 and 12.8 nmol), L-741 T742 (D4 antagonist; 1.5, 3 and 6 nmol) on food intake in FD3 chickens. At following, birds were ICV injected using 8-OH-DPAT (5-HT1A agonist; 15.25 nmol) and SB242084 (5-HT2C antagonist; 1.5 μg) prior dopamine (40 nmol) injection. Cumulative food intake was determined until 3 h post-injection. According to the results, dopamine significantly decreased food intake in chickens (p?<?0.05). The inhibitory effect of dopamine on food intake was decreased by SCH 23390 pretreatment (P?<?0.05), but AMI-193, NGB2904 and L-741, 742 had no effect on food intake induced by dopamine. In addition, hypophagic effect of dopamine was attenuated by SB242084 (P?<?0.05), but 8-OH-DPAT had no effect. These results suggest that dopamine decrease food intake via D1 receptor and there is an interaction between dopaminergic and serotonergic systems via 5-HT2C receptor in chickens. 相似文献
2.
F. Borna S. Luo N. M. Ahmad V. Nazeri M. Shokrpour R. Trethowan 《Genetic Resources and Crop Evolution》2017,64(3):479-492
Motherwort (Leonurus cardiaca L.) is a medicinal plant indigenous to the Mediterranean regions in Europe and Asia. The objective of this study is to apply inter-primer binding site (iPBS) markers to assess the molecular variation and genetic relationships of 89 genotypes of motherwort to assist the genetic improvement of this species. The genotypes comprised 79 from Iran and 10 collected in Australia and 15 additional accessions of two related species (L. heterophyllus Sweet and L. sibiricus L.) collected in Australia, were also included. PCR of 7 iPBS primers (dominant markers) produced a total of 191 bands ranging from 180 to 4000 bp and the mean PIC for primers ranged from 0.2213 to 0.3206 with a mean value 0.2921. The mean expected heterozygosity (0.134), the mean unbiased expected heterozygosity (0.140) and Shannon’s information index (0.213) indicated a high level of inbreeding among the accessions tested. Ordination and cluster analysis showed that the genetic relationships among all accessions could be separated into three major groups—L. cardiaca, L. heterophyllus and L. sibiricus. However, among the 89 accessions of L. cardiaca, genotypes collected from the same geographic region tended to cluster together thus indicating greater genetic similarity. The Motherwort accessions originating in Iran are highly divergent and possess abundant genetic diversity and clearly provide a basis for selection and breeding. The iPBS PCR-based genome fingerprinting technology used in this study is low-cost and effective in differentiating accessions of motherwort and their related species. 相似文献
3.
Background: Thiamine (VitB1) is a vitamin with various important physiological functions and postulated therapeutic effects. Its use as an analgesic in neuropathic pain has been undergoing in clinical settings. However, there has been little experimental investigation on this effect. In this study, anti-nociceptive and anti-inflammatory effects of thiamine were investigated in mice. Methods: Three doses of thiamine (50, 100 and 125 mg/kg) were used by intraperitoneal injection in this study. Acute and chronic anti-nociceptive effects were examined using hot plate test alone and after sciatic nerve ligation, respectively. Imipramine (40 mg/kg) was used as positive control. Anti-inflammatory effects of thiamine on acute and chronic inflammation were assessed using xylene-induced edema in ears and granuloma caused by compressed cotton implantation, respectively. Sodium diclofenac (15 mg/kg) was used as positive control. Open field test was performed to differentiate the mice responses in the acute anti-nociceptive tests. Results: All three doses of thiamine showed significant analgesic effects in non-ligated mice and also in neuropathic pain in ligated animals. Increasing the dose of thiamine correlated with a more pronounced and sustained effect. Acute anti-inflammatory investigation showed that thiamine injected 30 or 60 minutes before xylene application reduced the weight of edematic ears. However, the effect of thiamine was less pronounced than diclofenac. Furthermore, when injected once daily for 7 days, all doses of thiamine significantly reduced the weight of the cotton disks, showing suppression of granuloma formation. Conclusion: Taken together, it has been shown that thiamine possesses remarkable analgesic activities and also has significant anti-inflammatory effects, confirming its clinical use in controlling pain and less in inflammation. 相似文献
4.
Rosasco-Nitcher SE Lan W Khorasanizadeh S Stukenberg PT 《Science (New York, N.Y.)》2008,319(5862):469-472
The chromosome passenger complex (CPC) controls chromosome congression, kinetochore-microtubule attachments, and spindle checkpoint signaling during mitosis. Aurora-B kinase is the catalytic subunit of the CPC. To understand how a single kinase can regulate such diverse events, we have investigated the activation of Aurora-B and describe two distinct activation mechanisms. First, Aurora-B activation in vitro requires two cofactors, telophase disc-60kD (TD-60) and microtubules. TD-60 is critical to localize both the CPC and Haspin kinase activity to centromeres and thus regulates Aurora-B at several levels. Second, Aurora-B substrates can inhibit kinase activation, and this is relieved by phosphorylation of these substrates by the centromeric kinases Plk1 and Haspin. These regulatory mechanisms suggest models for phosphorylation by Aurora-B of centromeric substrates at unaligned chromosomes and merotelic attachments. 相似文献
5.
R. C. Sharma S. Rajaram S. Alikulov Z. Ziyaev S. Hazratkulova M. Khodarahami S. M. Nazeri S. Belen Z. Khalikulov M. Mosaad Y. Kaya M. Keser Z. Eshonova A. Kokhmetova M. G. Ahmedov M. R. Jalal Kamali A. I. Morgounov 《Euphytica》2013,190(1):19-31
High grain yield and resistance to stripe (yellow) rust are the most important traits for successful adoption of winter wheat varieties in Central and West Asia. This study was conducted to determine the stripe rust response and agronomic performance of a set of breeding lines recently developed by the International Winter Wheat Improvement Program (IWWIP). Replicated field studies were conducted in 2010 and 2011 using 38 experimental lines, one regional check (Konya) and one local check. Stripe rust scores were recorded at Karshi, Uzbekistan, and Karaj and Mashhad, Iran, in 2010. Grain yield was recorded at two sites each in Uzbekistan (Karshi and Kibray) and Iran (Karaj and Mashhad) and one site in Turkey (Eskisehir). The test lines showed variation for stripe rust severity, grain yield, 1,000-kernel weight, days to heading and plant height. Several stripe rust resistant genotypes were either higher yielding or equal to the local checks at different sites. Based on stripe rust resistance and yield performance in 2010, a set of 16 genotypes was selected and evaluated in 2011. All 16 were resistant at Almaty, Kazakhstan, and Dushanbe, Tajikistan, in 2011, whereas 9 of the 16 were resistant at Terter, Azerbaijan. The genotypes ‘TCI-02-138, ‘Solh’, ‘CMSS97M00541S’, ‘TCI -2-88(A)’ and ‘TCI-02-88(C)’ were consistently resistant to stripe across all sites in both years. Several lines showed high grain yields and superior agronomic performance across four sites in Uzbekistan and one site in Tajikistan. One genotype has been released in Uzbekistan and another in Tajikistan. 相似文献
6.
Saeed Hajirezaee Bagher Mojazi Amiri Mehdi Mehrpoosh Samane Nazeri Hamid Niksirat 《Aquaculture Research》2011,42(12):1789-1795
To determine the effect of gonadotropin releasing hormone‐analogue (GnRHa) treatment on the milt quality of endangered Caspian brown trout, Salmo trutta caspius, the sperm motility (percentage and duration of motility), sperm production (sperm density, spermatocrit and milt volume) and milt pH were measured for GnRHa‐treated (the treatment group) and untreated groups (the control group) during the spawning season. For untreated brooders, the values of the motility per cent, sperm density and spermatocrit decreased continuously during the spawning season while the milt volume, duration of motility and milt pH showed only a significant decrease at the end of the season. For GnRHa‐treated males, these parameters increased 14 days after GnRHa treatment (first milt collection) and then decreased continuously towards the end of the season. In addition, the values of milt and sperm density yielded per treated male were higher than that in the untreated group, although these were not statistically different. In any case, the total sum of yielded milt from the treatment group over the spawning season was higher than that in the untreated group. In this experiment, significant positive correlations were found between milt parameters as follows: sperm motility vs. milt pH; sperm density vs. spermatocrit; milt volume vs. spermatocrit; and milt volume vs. sperm density. The results show that the treatment of Caspian brown trout by GnRHa can improve the milt quality in terms of sperm motility and sperm production during a spawning season. 相似文献
7.
The Effects of Brackish Water on Growth Hormone/Insulin‐like Growth Factor‐1 Gene Expression of the Caspian Trout,Salmo trutta caspius (Kessler, 1877), During the Early Stage of Smoltification 
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The chromodomain of the HP1 family of proteins recognizes histone tails with specifically methylated lysines. Here, we present structural, energetic, and mutational analyses of the complex between the Drosophila HP1 chromodomain and the histone H3 tail with a methyllysine at residue 9, a modification associated with epigenetic silencing. The histone tail inserts as a beta strand, completing the beta-sandwich architecture of the chromodomain. The methylammonium group is caged by three aromatic side chains, whereas adjacent residues form discerning contacts with one face of the chromodomain. Comparison of dimethyl- and trimethyllysine-containing complexes suggests a role for cation-pi and van der Waals interactions, with trimethylation slightly improving the binding affinity. 相似文献
9.
Ali Khosravi Shakib Azizollah Khandan Mirkohi Sepideh Kalate Jari 《Compost science & utilization》2019,27(1):61-68
This study was carried out to evaluate the impact of irrigation regime and potting media on morpho-physiological and biochemical characteristics of pot marigold. The experiment was arranged factorially based on a completely randomized design. The first factor was irrigation regime in three levels of 80, 60 and 40% available water content and the second factor was potting media in five levels of 20% vermicompost, 30% vermicompost, 20% manure compost, 30% manure compost and control (sand and soil in equal proportions). Morpho-physiological traits (plant height, stem diameter, number of flowering stem, root diameter, root length, root dry weight, aerial dry weight, total dry weight, relative water content, ionic stability and water use efficiency) and biochemical traits (malondialdehyde content, catalase and peroxidase activity, chlorophyll and carotenoid contents) were measured. Morpho-physiological parameters, chlorophyll and carotenoid decreased under water deficit, while increased with application of vermicompost and manure compost. Also, lipid peroxidation, catalase and peroxidase activity enhanced under water deficit, while decreased with application of vermicompost and manure compost. In other words, the application of vermicompost and manure compost in potting media reduced the harmful effects of water deficit. Total dry mass and water use efficiency were about 3-fold higher in plants grown in 30% vermicompost or 30% manure compost substrate compared to those in control plants. The results suggest that the application of 30% manure compost could be recommended as suitable potting media due to reducing the negative effects of water shortages, helping to nourish the plant, cheapness and accessibility compared with 30% vermicompost. 相似文献
10.
Sepideh Heidari 《Archives of Agronomy and Soil Science》2016,62(1):19-35
Potassium (K) is one of the essential elements for plants. There has been enough research to determine pollution of nitrogen (N), phosphorus (P), and heavy metals in soil. However, by comparison research on the storage and transport of K has been neglected. Chemical fertilizer usage leads to serious environmental problems in Iran. Leaching of K can be affected by type of anions and cations present in the chemical fertilizers. Potassium leaching experiments were performed using 10 mM NH4Cl, (NH4)2HPO4, NH4H2PO4, NH4NO3, NH4OAC, CaCl2, Ca(NO3)2, NaNO3, and CO(NH3)2. The leaching experiment was lasted for 20 days (15 pore volumes). In addition, a set of experiments were conducted, where potato and wheat residues and poultry manure and sheep manure were added to soil at the rate of 5% and distilled water was used as the leaching solution to investigate impacts of organic residues on K leaching. In general, maximum K release was observed using NH4Cl (566 kg ha?1). Potato and wheat residues had maximum and minimum impacts on K leaching, respectively. Potassium fractionation was carried out after the end of the leaching experiment. The results indicated that leaching of soil in the presence of soluble salts and organic residues altered K distribution in different parts of soil. 相似文献