Incidence and risk factors for neurological signs after attenuation of single congenital portosystemic shunts in 253 dogs          下载免费PDF全文

Rhiannon Strickland BVetMed  Michael S. Tivers BVSc  PhD  DipECVS  Sophie E. Adamantos BVSc  DACVECC  DECVECC  Tom R. Harcourt‐Brown MA  VetMB  DipECVN  Robert C. Fowkes BSc  PhD  Victoria J. Lipscomb MA  VetMB  DipECVS 《Veterinary surgery : VS》2018,47(6):745-755

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Subcutaneous administration of ciclosporin in 11 allergic cats – a pilot open‐label uncontrolled clinical trial          下载免费PDF全文

Sandra N. Koch  Sheila M. F. Torres  Sandra Diaz  Sophie Gilbert  Aaron Rendahl 《Veterinary dermatology》2018,29(2):107-e43

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Reply          下载免费PDF全文

Sophie Adamantos 《The Journal of small animal practice》2015,56(12):729-729

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Genetic and non-genetic factors influencing KLH binding natural antibodies and specific antibody response to Newcastle disease in Kenyan chicken populations     

Sophie Miyumo  Chrilukovian B. Wasike  Evans D. Ilatsia  Jörn Bennewitz  Mizeck G. Chagunda 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2023,140(1):106-120

This study aimed at investigating the influence of genetic and non-genetic factors on immune traits to inform on possibilities of genetic improvement of disease resistance traits in local chicken of Kenya. Immune traits such as natural and specific antibodies are considered suitable indicators of an individual's health status and consequently, used as indicator traits of disease resistance. In this study, natural antibodies binding to Keyhole Limpet Hemocyanin (KLH-NAbs) was used to measure general disease resistance. Specific antibodies binding to Newcastle disease virus (NDV-IgG) post vaccination was used to measure specific disease resistance. Titers of KLH-NAbs isotypes (KLH-IgM, KLH-IgG and KLH-IgA) and NDV-IgG were measured in 1,540 chickens of different ages ranging from 12 to 56 weeks. A general linear model was fitted to determine the effect of sex, generation, population type, phylogenetic cluster, line, genotype and age on the antibody traits. A multivariate animal mixed model was fitted to estimate heritability and genetic correlations among the antibody traits. The model constituted of non-genetic factors found to have a significant influence on the antibody traits as fixed effects, and animal and residual effects as random variables. Overall mean (±SE) concentration levels for KLH-IgM, KLH-IgG, KLH-IgA and NDV-IgG were 10.33 ± 0.04, 9.08 ± 0.02, 6.00 ± 0.02 and 10.12 ± 0.03, respectively. Sex, generation and age (linear covariate) significantly (p < 0.05) influenced variation across all the antibody traits. Genotype effects (p < 0.05) were present in all antibody traits, apart from KLH-IgA. Interaction between generation and line was significant (p < 0.05) in KLH-IgM and NDV-IgG while nesting phylogenetic cluster within population significantly (p < 0.05) influenced all antibody traits, apart from KLH-IgA. Heritability estimates for KLH-IgM, KLH-IgG, KLH-IgA and NDV-IgG were 0.28 ± 0.08, 0.14 ± 0.06, 0.07 ± 0.04 and 0.31 ± 0.06, respectively. There were positive genetic correlations (0.40–0.61) among the KLH-NAbs while negative genetic correlations (−0.26 to −0.98) were observed between the KLH-NAbs and NDV-IgG. Results from this study indicate that non-genetic effects due to biological and environmental factors influence natural and specific antibodies and should be accounted for to reduce bias and improve accuracy when evaluating the traits. Subsequently, the moderate heritability estimates in KLH-IgM and NDV-IgG suggest selection possibilities for genetic improvement of general and specific immunity, respectively, and consequently disease resistance. However, the negative correlations between KLH-NAbs and NDV-IgG indicate the need to consider a suitable approach that can optimally combine both traits in a multiple trait selection strategies.  相似文献   

Use of hyposensitization injections to control seasonal pruritus in a Bactrian camel (Camelus bactrianus).     

Laurie J Gage  Sophie I J Vandenabeele  Stephen D White 《Journal of zoo and wildlife medicine》2005,36(1):88-94

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Validation for use with coyotes (Canis latrans) of a commercially available enzyme-linked immunosorbent assay for Dirofilaria immitis     

Sacks BN  Chomel BB  Kasten RW  Chang CC  Sanders RK  Leterme SD 《Veterinary parasitology》2002,109(1-2):45-58

Serological tests offer a potentially powerful tool for monitoring parasites in wildlife populations. However, such tests must be validated before using them with target wildlife populations. We evaluated in coyotes (Canis latrans) the performance of a commercially available serological test used to detect canine heartworm (Dirofilaria immitis) in domestic dogs. We obtained 265 coyote carcasses and serological specimens from 54 additional coyotes from several regions of California, USA. We necropsied coyotes to determine the adult heartworm infection status. Blood was collected at necropsy on filter paper strips and allowed to dry; it was later eluted in a buffer solution, and the supernatant was tested for heartworm. Receiver operating characteristic (ROC) analysis was used to assess discriminatory power of the test and indicated a 93% probability that a randomly selected infected coyote would exhibit a higher enzyme-linked immunosorbent assay (ELISA) value than a randomly selected uninfected coyote. We estimated specificity at 96% (95% CI: 92-98%) for 165 uninfected coyotes and sensitivity at 85% (77-91%) for 100 infected coyotes, results similar to published values for the commercial serological test used with dog serum or plasma. Test performance was similar for filter paper specimens and supernatant of frozen whole blood collected in EDTA tubes (i.e. hemolyzed plasma). We found no difference in test performance among geographic or demographic coyote groups. Our findings support application of the test to filter paper or standard serological specimens for detection of heartworm in coyote populations.  相似文献   

Clinically relevant physiology of the neonate.     

Sophie A Grundy 《Veterinary Clinics of North America: Small Animal Practice》2006,36(3):443-59, v

During the 4- to 6-week neonatal period (birth to weaning), the physiology of canine and feline neonates undergoes dramatic change. Despite the neonate having the appearance of a miniature adult, their unique physiology has a significant impact on physical examination and laboratory test interpretation and may limit diagnostic capabilities and therapeutic options. In this article, the most striking physiologic differences between neonatal and adult body systems are discussed with respect to the resulting clinical implications.  相似文献   

Primary meningeal T-cell lymphoma in a harbor seal (Phoca vitulina).     

Sophie Labrut  Monique Wyers  Julien Miclard  Marie-Anne Colle 《Journal of zoo and wildlife medicine》2007,38(2):323-328

A 15-year-old female harbor seal (Phoca vitulina) was referred to the Nantes Veterinary School, Nantes, France, with a clinical history of anorexia, seizures, and left hemiplegia. Cerebrospinal fluid analysis revealed large numbers of neoplastic lymphoid cells. After injection of a contrast agent into the cerebrospinal space, radiographs demonstrated an asymmetry of the right lateral ventricle. Necropsy examination revealed a marked edema of the right frontal lobe, extending to the basal nuclei and thalamus in the brain. Histological examination of the brain revealed leptomeningeal lymphoma. Immunohistochemical labeling demonstrated that the neoplasm was of T-cell origin. No significant macroscopic or microscopic lesions were observed in the other organs examined, including lymphoid organs. This is the first report of primary leptomeningeal lymphoma in a harbor seal.  相似文献   

Treatment of diplomonad intestinal parasites with magnesium sulphate at a commercial rainbow trout (Oncorhynchus mykiss) facility     

Sophie St-Hilaire  Derek Price  Shawna Taylor  David Groman 《The Canadian veterinary journal. La revue veterinaire canadienne》2015,56(8):876-878

Rainbow trout (average weight of 2 g) in fresh water experienced high mortality and were infected with a diplomonad intestinal parasite. Tanks of fish experienced an immediate reduction in mortality after an in-feed treatment with 3% Epsom salts for 2 d. Treatments had to be applied several times, but in each case there was a similar reduction in mortality.  相似文献   

Atypical canine recurrent alopecia     

Sophie I. J. Vandenabeele  Jan Declercq  Sylvie Daminet  Ilona Schwarzkopf  Hilde E. V. De Cock 《Veterinary dermatology》2014,25(1):56-58

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