Two cases of adiaspiromycosis in the Japanese pika (Ochotona hyperborea yesoensis Kishida)     

H Taniyama  H Furuoka  T Matsui  T Ono 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1985,47(1):139-142

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Distribution of inclusion bodies in tissues from 100 dogs infected with canine distemper virus     

Kubo T  Kagawa Y  Taniyama H  Hasegawa A 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2007,69(5):527-529

One hundred dogs that were positive for canine distemper virus antigen and inclusion bodies in the tonsils were examined for the distribution of inclusion bodies in various tissues. Inclusion bodies were found in the lungs (70 dogs), brains (20 dogs), urinary bladders (73 dogs), stomachs (78 dogs), spleens (77 dogs), and lymph nodes (81 dogs) of the dogs. Based on these results, the tonsils may be the most suitable tissue for detection of inclusion bodies in canine distemper.  相似文献   

Immunohistochemical detection of apolipoprotein B-100 and immunoglobulins (IgA, IgM, IgG) in the splenic arteries of aging dogs     

Sako T  Uchida E  Kagawa Y  Hirayama K  Takahashi T  Nakade T  Niiyama M  Izumisawa Y  Taniyama H 《Veterinary pathology》2001,38(4):407-413

Accumulation of lipids and hyalinosis in the splenic arteries of aged dogs are frequently detected by routine histopathologic examinations. The purpose of this study was to pinpoint the localization of canine apolipoprotein B-100 (CApoB-100) and immunoglobulins (IgA, IgM, IgG) in the splenic arteries of aging dogs (n = 80) through the use of immunohistochemical techniques. CApoB-100 deposits were found in the subendothelial space, extracellular matrix, and atheromatous lesions in the tunica media of the arteries in dogs > or = 6 years of age. Foamy cytoplasm of the infiltrated macrophages was also CApoB-100 immunopositive. In dogs > or = 10 years of age, almost all central arteries were CApoB-100 immunopositive. Hyaline deposits within the wall were characterized by immunopositivity against canine IgA, IgM, IgG, and albumin. Lipid accumulation in splenic arteries may be an age-related lesion and a precursor of the atheromatous plaques associated with splenic hemorrhage and infarcts later in life. In addition, deposition of immunoglobulins, probably mediated by immune complexes, may play an important role in the development of canine vascular diseases similar to human disease.  相似文献   

Immunohistochemical evaluation of a malignant phecochromocytoma in a wolfdog   总被引：1，自引：0，他引：1  

Sako T  Kitamura N  Kagawa Y  Hirayama K  Morita M  Kurosawa T  Yoshino T  Taniyama H 《Veterinary pathology》2001,38(4):447-450

A malignant pheochromocytoma with multiple metastases was diagnosed in a 7-year-old male wolfdog that resulted from a cross between an eastern timber wolf (Canis lupus lycaon) and an Alaskan malamute. A yellowish white neoplastic mass approximately 10 cm diameter was found in the right adrenal gland. The neoplasm penetrated through the wall of the caudal vena cava. A diagnosis of pheochromocytoma was established by histopathologic and immunohistochemical procedures. Immunohistochemically, the neoplastic cells expressed chromogranin A, substance P, synaptophysin, Leu-7, protein gene product 9.5, methionine-enkephalin, S100 protein, and galanin. Multiple metastatic tumors were found in the kidneys, spleen, lungs, heart, and liver.  相似文献   

Classification of abomasal displacement in cows according to histopathology of the liver and clinical chemistry     

Komatsu Y  Itoh N  Taniyama H  Kitazawa T  Yokota H  Koiwa M  Ohtsuka H  Terasaki N  Maeno K  Mizoguchi M  Takeuchi Y  Tanigawa M  Nakamura T  Watanabe H  Matsuguchi Y  Kukino T  Honma A 《Journal of veterinary medicine. A, Physiology, pathology, clinical medicine》2002,49(9):482-486

Histopathological features of livers and blood chemical values in cows with abomasal displacement were investigated. Liver biopsy samples were collected during redressment operations in 92 cows with abomasal displacement, and the samples were stained with haematoxylin and eosin or periodic acid Schiff (PAS). Blood was collected for chemical tests. Livers were histopathologically divided into the following four types: normal histology cases (21%), fatty degeneration cases (36%), cloudy swelling cases (19%) and fatty degeneration cases with cloudy swelling (24%). The number of PAS-positive samples was significantly higher in the normal histology group and significantly lower in the severe fatty degeneration group and severe cloudy swelling group. Cows with fatty degeneration had significantly higher levels of serum 3-hydroxybutyric acid, non-esterified fatty acid and aspartate aminotransferase than did those with cloudy swelling or normal histology. The results indicate that the morbid conditions of cows with abomasal displacement can be classified into four types.  相似文献   

A pleomorphic adenoma of the lacrimal gland in a dog   总被引：1，自引：0，他引：1  

Hirayama K  Kagawa Y  Tsuzuki K  Kotani T  Azuma Y  Yoshino T  Taniyama H 《Veterinary pathology》2000,37(4):353-356

A 13-year-old female mongrel dog had a pleomorphic adenoma of the lacrimal gland in the right upper orbit. The tumor measured 3.8 x 3.0 x 3.3 cm, appeared white, round, and firm, and pressed the right globe and surrounding tissues. Histopathologically, the tumor had a thin connective tissue capsule and was composed of tubules with two cell types, some resembling luminal epithelial cells making up the tubular structures and the other of myoepithelial cells. Epithelial tubules were disposed in an adenomatous fashion and separated from each other by proliferating pleomorphic myoepithelial cells. Immunohistochemically, large numbers of the luminal epithelial cells revealed an immunopositive reaction against keratin/cytokeratin (AE1/AE3), and some epithelial cells reacted against cytokeratin 14. Spindle-shaped myoepithelial cells revealed an immunopositive reaction against cytokeratin 14, alpha-smooth muscle actin, and vimentin. A small number of myoepithelial cells reacted against desmin. S-100 protein immunopositivity was frequently found in luminal epithelial cells and rarely in the pleomorphic myoepithelial cells. Glial fibrillary acidic protein positivity was commonly found in myoepithelial cells, myxoid matrices, and intracystic materials, but not in luminal epithelial cells.  相似文献   

Histological and histochemical observations on the muscular lesions in a newborn calf with hydranencephaly     

H Taniyama  H Furuoka  T Matsui  T Ono 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1985,47(1):151-155

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Balenine,imidazole dipeptide,induces activation of superoxide dismutase in myotubes     

Yang  Min  Sun  Luchuanyang  Kawabata  Yasunosuke  Maegawa  Takahiro  Taniyama  Shigeto  Tachibana  Katsuyasu  Hirasaka  Katsuya 《Fisheries Science》2021,87(3):403-409

Balenine is one of the endogenous imidazole dipeptides. It is composed of beta-alanine and 3-methyl-l-histidine, which exist mainly in the muscles and the brain. The exact biological properties of balenine are still not well known, although the antioxidant activity of carnosine, another imidazole dipeptide, is known. In this study we investigated whether balenine exhibits antioxidant activity. It was found to decrease the superoxide anion (O₂⁻) and increased hydrogen peroxide (H₂O₂) generation. We found that SOD activity increased in balenine-treated C2C12 myotubes, although balenine did not increase expression of SOD mRNA. On the other hand, there were no changes in other antioxidant enzymes, CAT and GPX activity, and mRNA levels. In an in vitro assay, the direct activation of SOD treated by balenine was significantly higher than with carnosine treatment. Moreover, balenine constituent amino acids did not have the ability to activate SOD. Our results suggest that balenine contributes to antioxidant effects through activation of SOD.

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Detection of an isoform of alpha(1)-antitrypsin in serum samples from foals with gastric ulcers     

Taharaguchi S  Nagano A  Okai K  Miyasho T  Kuwano M  Taniyama H  Yokota H 《The Veterinary record》2007,161(10):338-342

The objective of this study was to find serum indicators of gastric ulcers in foals. By using two-dimensional electrophoresis of serum proteins, three distinct spots were detected in samples from foals with gastric ulcers detected endoscopically. One of them appeared with high frequency and was identified by partial digestion with trypsin and subsequent nano-electrospray ionisation-tandem mass spectrometry (nanoesi-ms/ms) analysis as an alpha(1)-antitrypsin. Western blot analysis, using an antibody against human alpha(1)-antitrypsin, revealed at least two bands, of molecular weight 58 kDa and 55 kDa, in the sera. The 55 kDa band was detected in 44 of 47 serum samples from foals with gastric ulcers, but in only three of 22 serum samples from healthy foals.  相似文献   

A case of Hyostrongylus rubidus infection in a pig     

T Sarashina  H Taniyama 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1986,48(1):163-167

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