Interferon-resistant cell line lacks fatty acid cyclooxygenase activity   总被引：3，自引：0，他引：3  

K A Chandrabose  P Cuatrecasas  R Pottathil  D J Lang 《Science (New York, N.Y.)》1981,212(4492):329-331

A clone of L1210 mouse leukemia cells selected for resistance to both the antiviral and anticellular properties of mouse interferon were essentially devoid of fatty acid cyclooxygenase activity. Experiments in which broken cell preparations were mixed or the two cell types were cultivated together failed to indicate the presence of a diffusible enzyme inhibitor. Fatty acid lipoxygenase activity of similar magnitude was detectable in both cell types. A selective impairment of fatty acid cyclooxygenase in interferon-resistant cells is consistent with recently described data suggesting that this enzyme may play a crucial role in mediating the antiviral and anticellular effects of interferon.  相似文献   

Evolutionary and biomedical insights from the rhesus macaque genome   总被引：1，自引：0，他引：1  

Rhesus Macaque Genome Sequencing  Analysis Consortium  Gibbs RA  Rogers J  Katze MG  Bumgarner R  Weinstock GM  Mardis ER  Remington KA  Strausberg RL  Venter JC  Wilson RK  Batzer MA  Bustamante CD  Eichler EE  Hahn MW  Hardison RC  Makova KD  Miller W  Milosavljevic A  Palermo RE  Siepel A  Sikela JM  Attaway T  Bell S  Bernard KE  Buhay CJ  Chandrabose MN  Dao M  Davis C  Delehaunty KD  Ding Y  Dinh HH  Dugan-Rocha S  Fulton LA  Gabisi RA  Garner TT  Godfrey J  Hawes AC  Hernandez J  Hines S  Holder M  Hume J  Jhangiani SN 《Science (New York, N.Y.)》2007,316(5822):222-234

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Growth Performance of Triploid Red Tilapia Reared Under Laboratory Conditions     

Padmaja J. Pradeep  Thekkeparambil C. Srijaya  Anuar Hassan  Anil K. Chatterji  Rajeev Raghavan  Boonsirm Withyachumnarnkul 《Journal Of Applied Aquaculture》2013,25(2):176-189

Triploidy could reduce breeding activity in tilapia without the use of hormones. In this study, the effect of triploidy on survival, growth, and gender of a line of red hybrid tilapia (Oreochromis mossambicus X Oreochromis niloticus) was assessed relative to the performance of diploid siblings. Triploidy was induced by preventing second polar body extrusion by applying either heat or cold shock. Growth was similar for both ploidies during the first 90 days of culture. However, at the age of 120 days, the average body weight of triploids produced by heat shock (215.5 ± 3.61 g) was significantly higher than that of cold shock (192.7 ± 2.6 g) and the diploid control (191.9 ± 1.74 g). Survival among triploids was inferior to diploids. Percentage of males in the triploid population was 82.9% in the heat-shocked treatment group, 54.8% in the cold-shock treatment, and 50% in the diploid control. Maximum attainable weight of red tilapia was calculated by applying the Ford-Walford growth plot: 650 g (heat-shocked triploids), 490 g (cold-shocked triploids), and 440 g in the diploid control.  相似文献   

Optimal conditions for cold-shock induction of triploidy in red tilapia     

Padmaja Jayaprasad Pradeep  Thekkeparambil Chandrabose Srijaya  Anuar Hassan  Anil Kumar Chatterji  Boonsirm Withyachumnarnkul  Andrew Jeffs 《Aquaculture International》2014,22(3):1163-1174

Production of sterile triploid red tilapia [Oreochromis mossambicus (Mozambique tilapia); Peters, 1852 × Oreochromis niloticus (Nile tilapia); Linnaeus, 1758] is an effective strategy to overcome their prolific breeding. Optimal conditions for cold-shock induction of triploidy in red tilapia were investigated by experimentally examining two variables: appropriate temperature of the shock and duration of shock treatment. A constant time after insemination of 4 min was used to determine the best combination of temperature (6, 7, 8, 9, 11, 13, 15 °C) with different durations of shock (10, 20, 30, 40, 50 min) with resultant ploidy level verified karyotypically. Shock duration for 30 min at a temperature of 9 °C was found most effective in producing maximum triploidy (98.7 %) with higher rates of hatching (63.2 %) and survival up to yolk-sac stage (75.8 %). The chromosome count confirmed that triploid percentages were higher when cold shock was used for longer durations at each temperature; however, hatching rates were generally decreased. The maximum triploid yield (82.1 %) obtained was higher than the yield obtained using heat shock (72.7 %) in red tilapia previously. The application of the results of this study has the potential to greatly improve the production of triploid red tilapia in commercial aquaculture.  相似文献   

Oxygen consumption in trilobite larvae of the mangrove horseshoe crab (Carcinoscorpius rotundicauda; Latreille, 1802): effect of temperature,salinity, pH,and light–dark cycle     

Srijaya  Thekkeparambil Chandrabose  Pradeep  Padmaja Jayaprasad  Hassan  Anuar  Chatterji  Anil  Shaharom  Faizah  Jeffs  Andrew 《International Aquatic Research》2014,6(1):1-13

A set of feeding trials was carried out for different microalgal species and processed diets for the culture of the New Zealand pipi, Paphies australis. Five microalgal species (Isochrysis galbana clone T-ISO, Pavlova lutheri, Tetraselmis suecica, Chaetoceros muelleri, and Thalassiora pseudonana clone 3H) and three formulated diets (baker's yeast, wheat flour, and corn flour) were fed to spat, juvenile, and adult pipi for 21 days. Unfed pipi were used in the control group. The spat and juvenile pipi showed a major shell increase with I. galbana while the greatest wet weight increase was obtained with P. lutheri. The shells of adult pipi grew better with corn flour, and the P. lutheri-fed group obtained the greatest wet weight. Results of proximate analysis in adult pipi revealed that proteins and lipids were accumulated in the tissue for all fed groups, while carbohydrate levels were depleted in all treatments including the control group. It is suggested that the gonads have developed during the experiment.  相似文献