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本研究旨在研究高蛋白饲料添加虎杖对雏鹅生长性能、肾功能、血清炎症因子和盲肠菌群结构的影响。试验将70只1日龄扬州雏鹅随机分为高蛋白组和高蛋白+3%虎杖组，每组5个重复，每个重复7只，高蛋白组饲喂粗蛋白质为24%的高蛋白饲料，高蛋白+3%虎杖组饲喂含3%虎杖的高蛋白饲料。试验为期15?d。结果显示：与高蛋白组比较，高蛋白+3%虎杖组平均体重、平均日增重显著升高，料重比显著降低（P＜0.05）|血清尿酸、尿素氮和肌酐水平及黄嘌呤氧化酶活性显著降低（P＜0.05）|血清脂多糖（LPS）、IL-6、TNF-α和IL-1β水平均显著降低（P＜0.05）。与高蛋白组比较，高蛋白+3%虎杖组盲肠菌群OTU数、Chao1指数和Shannon指数升高，在门水平，拟杆菌门和变形菌门相对丰度显著降低（P＜0.05），放线菌门相对丰度升高，在属水平，苏黎世杆菌属、乳酸杆菌属和罗斯氏菌属相对丰度升高，拟杆菌属和梭菌属相对丰度降低（P＜0.05）。综上，高蛋白饲料中添加虎杖可以提高雏鹅生长性能，降低血清尿酸和炎症因子水平，改善肾功能。
[关键词]虎杖|雏鹅|高蛋白饲料|肾功能|炎症因子|盲肠菌群 相似文献
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The aim of this study was to evaluate the effects of MCC950 on growth performance, uric acid metabolism, serum inflammatory factor contents and kidney injury of goslings a fed high protein diet, and explore the potential mechanism of nucleotide binding oligomerization domain-like receptor 3 (NLRP3) / cysteine aspartase-1 (Caspase-1) signaling pathway in gosling gout. A total of 120 Yangzhou goslings of 1-day-old were randomly divided into 3 groups, which were control group, high protein group (HP group) and high protein+ MCC950 group (HP+MCC950 group), with 5 replicates in each group and 8 goslings in each replicate. The control group was fed a normal protein diet with 16.5% crude protein, and the HP group and HP+MCC950 group were fed a high protein diet with 24.0% crude protein. The HP+MCC950 group was intraperitoneally injected with MCC950 every 3 days at a dose of 10 mg / kg BW, and the other two groups were injected with the same amount of normal saline. The experiment lasted for 15 days. The results showed as follows: 1) compared with the control group, the average body weight of goslings at 15 days of age in the HP group was significantly decreased (P<0.05); the serum contents of uric acid (UA), creatinine (Cr), urea nitrogen (UN), C-reactive protein (CRP), interleukin-1β (IL-1β), interleukin 18 (IL-18), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α) and transforming growth factor β1 (TGF-β1) in the HP group were significantly increased (P<0.05); the mRNA relative expression levels of NLRP3, Caspase-1, IL-1β and IL-18 and the protein relative expression levels of NLRP3, Caspase-1 and IL-1β in kidney tissues in the HP group were significantly increased (P<0.05). 2) Compared with the HP group, the average body weight of goslings at 10 and 15 days of age in the HP+MCC950 group was significantly increased (P<0.05); the serum contents of UA, Cr, UN, CRP, IL-1β, IL-18, IL-6, TNF-α and TGF-β1 were significantly decreased (P<0.05), while the mRNA relative expression levels of NLRP3, Caspase-1, IL-1β and IL-18 and the protein relative expression levels of NLRP3, Caspase-1 and IL-1β in kidney tissues in the HP+MCC950 group were significantly decreased (P< 0.05). 3) Histological findings showed that the renal tubules of goslings were dilated, and vacuolar degeneration and necrosis occurred in the HP group, while the structure of renal tubules was relatively normal in the HP+MCC950 group. The urate deposition area in kidney tissues of goslings in the HP group was significantly larger than that in the control group (P<0.05), and which in the HP+MCC950 group was significantly smaller than that in the HP group (P<0.05). Moreover, the urate deposition area in kidney tissues of goslings was significantly positively correlated with the protein relative expression level of NLRP3 (r = 0.681, P<0.05). In conclusion, MCC950 can promote the growth of goslings fed a high protein diet and reduce the serum uric acid content, which may be related to the reduction of inflammatory response and kidney injury through its inhibition of NLRP3 / Caspase-1 signaling pathway. © 2023 Authors. All rights reserved. 相似文献
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