Precocene II metabolism: Comparative in vivo studies among several species of insects,and structure elucidation of two major metabolites     

B.J. Bergot  K.J. Judy  D.A. Schooley  L.W. Tsai 《Pesticide biochemistry and physiology》1980,13(2):95-104

Several species of insects, exhibiting varying responsiveness to the juvenile hormone antagonist precocene II (6,7-dimethoxy-2,2-dimethylchromene), were challenged topically with a tritiated preparation of the title compound. Metabolism of [³H]precocene II was subsequently examined by withdrawing hemolymph samples from treated animals at appropriate time intervals and characterizing the extractable radiolabel chromatographically. Quantitative (or qualitative) differences observed between the respective metabolic profiles were found not correlative with specimen sensitivity to precocene. Production of two heretofore unreported metabolites, identified by spectral and chemical means as O-β-glucosides of 6- and 7-monodemethylated precocene II, was demonstrated in both sensitive and insensitive species. No evidence for the presence of a hemolymphborne, biologically effective “activated metabolite” produced in vivo by precocene-susceptible insects could be found. The latter finding may well argue for in situ bioactivation of precocene at the target tissue(s) by these sensitive insects.  相似文献   

Effects of time delay and blood storage methods on analysis of canine venous blood samples with an Element point-of-care analyzer     

Angie A. Rincon  Virginie A. Wurlod  Chin-Chi Liu  M. Ryan Smith 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2023,52(1):22-29

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Patterns of antimicrobial susceptibility in Michigan wildlife and bovine isolates of Mycobacterium bovis.     

Meighan Daly  Kelly L Diegel  Scott D Fitzgerald  Angie Schooley  Dale E Berry  John B Kaneene 《Journal of veterinary diagnostic investigation》2006,18(4):401-404

The state of Michigan has recognized the presence of Mycobacterium bovis in its free-ranging white-tailed deer population since 1994. This endemic infection is primarily located in a 12-county area in the northeastern lower peninsula of Michigan. A statewide surveillance and eradication program of the disease has been in effect since 1994. Worldwide, Mycobacterium tuberculosis complex organisms have a known predilection toward development of antimicrobial resistance. The objective of this study was to investigate the antimicrobial susceptibility of M. bovis isolates from white-tailed deer in Michigan and detect any changes in susceptibility over time. M. bovis isolates from 2 fall hunting seasons (1999 and 2004) were used in this study. The fall season of 2004 marked the first documented case of direct transmission of M. bovis from a wild deer to a human in Michigan. Since M. bovis is a zoonotic disease, knowledge of susceptibility can expedite treatment options in humans. M. bovis isolates were obtained from 58 deer, 4 coyotes, 3 cattle, 2 raccoons, and 1 human case from the 2 years combined. Methods of susceptibility testing included 1% proportion agar plates and Bactec radiometric broth testing. M. bovis was found to be uniformly resistant to the antibiotic pyrazinamide; this resistance is common to all M. bovis isolates. No other antimicrobial resistance was found in any of the tested M. bovis isolates, which may be, in part, attributed to the lack of any significant treatment pressure in wildlife.  相似文献   

Environmental degradation of the insect growth regulator methoprene. VII. Bovine metabolism to cholesterol and related natural products.     

G B Quistad  L E Staiger  B J Bergot  D A Schooley 《Journal of agricultural and food chemistry》1975,23(4):743-749

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Whither or wither microbicides?     

Grant RM  Hamer D  Hope T  Johnston R  Lange J  Lederman MM  Lieberman J  Miller CJ  Moore JP  Mosier DE  Richman DD  Schooley RT  Springer MS  Veazey RS  Wainberg MA 《Science (New York, N.Y.)》2008,321(5888):532-534

After disappointing results from all efficacy trials conducted to date, the field of microbicides research now faces substantial challenges. Poor coordination among interested parties and the choice of nonvalidated scientific targets for phase III studies have hampered progress and created mistrust about the use of microbicides as a method to prevent HIV-1 sexual transmission. Although new promising strategies are available, there will need to be serious reappraisals of how decisions are made to advance the next generations of candidates into clinical trials, and the use of appropriate animal models in this process will be critical.  相似文献   

Environmental degradation of the insect growth regulator methoprene. X. Chicken metabolism.     

G B Quistad  L E Staiger  D A Schooley 《Journal of agricultural and food chemistry》1976,24(3):644-648

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Environmental degradation of the miticide cycloprate (hexadecyl cyclopropanecarboxylate). 3. Bovine metabolism   总被引：1，自引：0，他引：1  

G B Quistad  L E Staiger  D A Schooley 《Journal of agricultural and food chemistry》1978,26(1):71-75

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CVMA E-LEARNING COURSE OF THE MONTH          下载免费PDF全文

Angie Herzog 《The Canadian veterinary journal. La revue veterinaire canadienne》2003,44(1):27-28

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EMBRACE THE SPIRIT OF WINNIPEG: at the 55th Annual CVMA Convention · July 9–12, 2003 · Winnipeg, Manitoba          下载免费PDF全文

Angie Herzog 《The Canadian veterinary journal. La revue veterinaire canadienne》2003,44(4):285

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Management program for improving sow and gilt performance by feeding dichlorvos     

D G Siers  M A Schooley  L J Brown  H C Stanton 《American journal of veterinary research》1977,38(12):1997-1999

Treated sows were on a special management program which consisted of feeding 1,000 mg of dichlorvos to the sow each day for the last 30 days of gestation. The dichlorvos was delivered as a slow-release formulation. The late gestation treatment signigicantly (P less than 0.01) improved the productivity of the sows by improving the performance of their litters. The litters from treated sows were superior in 4 ways: (1) increased number of pigs born alive per litter (2.3%); (2) increased pig birth weights (9.6%); (3) improved survival of pigs born alive; and (4) improved growth rate to market weight. The litters from treated sows were 11.6%, 16.5%, and 12.4% heavier than control litters at birth, weaning (35 days), and market (160 days), respectively.  相似文献