Actinomycin D for Reinduction of Remission in Dogs With Resistant Lymphoma     

Anthony S. Moore BVSc  MVSc    Gregory K. Ogilvie  David M. Vail 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1994,8(5):343-344

Twenty-five dogs with malignant lymphoma refractory to chemotherapy were treated with actinomycin D at a median dose of 0.7 mg/m² (range, 0.5 to 0.9 mg/m²) every 3 weeks. The dogs treated had received between 2 and 8 chemotherapeutic agents (median 7), for a median of 266 days before being treated with actinomycin D. For 23 of the 25 dogs, previous chemotherapy included doxorubicin. No dog responded to actinomycin D chemotherapy.  相似文献   

Verification by polymerase chain reaction of vertical transmission of Theileria sergenti in cows   总被引：2，自引：0，他引：2       下载免费PDF全文

Byeong K. Baek  Kim B. Soo  Jin H. Kim  Jin Hur  Bou O. Lee  J. M. Jung  Misao Onuma  Anthony O. Oluoch  Chang-Hyun Kim    Ibulaimu Kakoma 《Canadian journal of veterinary research》2003,67(4):278-282

To evaluate the transplacental transfer of Theileria sergenti infection in cattle, we used DNA probes to detect T. sergenti in 6 pregnant cows and their calves. All the animals were monitored by parasitologic, serologic, and polymerase chain reaction (PCR) assays for a predicted 875-base-pair (bp) DNA product and a 684-bp amplicon detected by nested PCR in the blood and spleens of aborted fetuses. An open reading frame (ORF) starting at nucleotide 170 and terminating at position 1021 was shown to code for a polypeptide of 283 amino acid residues. All 6 dams and 5 calves were positive for T. sergenti in all tests. One calf was positive only with nested PCR. We conclude that transplacental transmission of T. sergenti is a significant problem. The relevance of the data in the programmed introduction of new (especially pregnant) animals into established clean herds needs serious consideration with regard to control of theileriosis and other tickborne diseases.  相似文献   

A Prospective Study Of Intravenous Catheter Contamination     

Karol A. Mathews DVM  DVSc  Melanie J. Brooks RVT  Anne E. Valliant BSC 《Journal of Veterinary Emergency and Critical Care》1996,6(1):33-43

A one year prospective study was conducted to determine the association between intravenous catheter contamination and increased dwell time, and to identify any related risk factors. Intravenous catheters obtained from 23 cats and 98 dogs in the Intensive Care Unit at the Ontario Veterinary College with dwell times > 72 hours for the test group (n=58) and < 72 hours for a corresponding control group (n=63) were cultured between April 1991 and March 1992. One hundred and twenty one catheters were cultured, 16 jugular, 99 cephalic, and 6 saphenous. The overall contamination rate was 13 out of 121 catheters cultured (10.7%); 9/63 (14.3%) control and 4/58 (6.9%) test catheters. The bacteria isolated were E.aerogenes, S.aureus (3), P.aeruginosa, P.multocida, and Bacillus sp (7). The Bacillus sp positive catheters (5 control and 2 test) were placed during a five day period, and contaminated gauze squares were identified as the source of infection in these catheters. After these were removed from the study, the group infection rate was 6.9% control and 3.6% test. There was no significant difference between groups and no associated risk factors were identified. We conclude that intravenous dwell time need not be restricted to <72 hours.  相似文献   

Transmutation and functional representation of heterogeneous landscapes   总被引：3，自引：0，他引：3  

Anthony W. King  Alan R. Johnson  Robert V. O'Neill 《Landscape Ecology》1991,5(4):239-253

Models of local small-scale ecological processes can be used to describe related processes at larger spatial scales if the influences of increased scale and heterogeneity are carefully considered. In this paper we consider the changes in the functional representation of an ecological process that can occur as one moves from a local small-scale model to a model of the aggregate expression of that process for a larger spatial extent. We call these changes spatial transmutation. We specifically examine landscape heterogeneity as a cause of transmutation. Spatial transmutation as a consequence of landscape heterogeneity is a source of error in the prediction of aggregate landscape behavior from smaller scale models. However, we also demonstrate a procedure for taking advantage of spatial transmutation to develop appropriately scaled landscape functions. First a mathematical function describing the process of interest as a local function of local variables is defined. The spatial heterogeneity of the local variables is described by their statistical distribution in the landscape. The aggregate landscape expression of the local process is then predicted by calculating the expected value of the local function, explicitly integrating landscape heterogeneity. Monte Carlo simulation is used to repeat the local-to-landscape extrapolation for a variety of landscape patterns. Finally, the extrapolated landscape results are regressed on landscape variables to define response functions that explain a useful fraction of the total variation in landscape behavior. The response functions are hypotheses about the functional representation of the local process at the larger spatial scale.  相似文献   

Nephrotoxicity in dogs associated with methoxyflurane anesthesia and flunixin meglumine analgesia   总被引：2，自引：2，他引：0       下载免费PDF全文

Mathews KA  Doherty T  Dyson DH  Wilcock B  Valliant A 《The Canadian veterinary journal. La revue veterinaire canadienne》1990,31(11):766-771

Uremia unexpectedly developed in five dogs 24 hours after undergoing thoracotomy in a student laboratory. In all dogs general anesthesia had been maintained with methoxyflurane, muscle relaxation had been induced with gallamine, and each dog received a single intravenous dose of 1.0 mg/kg flunixin meglumine for analgesia upon termination of anesthesia. In a subsequent group of dogs undergoing an orthopedic procedure, we assessed the effects on renal function of methoxyflurane anesthesia plus oxymorphone, or of methoxyflurane or halothane anesthesia in combination with a single IM 1.0 mg/kg dose of flunixin meglumine. Significant elevations in serum urea and creatinine values, and necrosis of collecting ducts and loops of Henle, were noted only in the dogs receiving methoxyflurane and flunixin meglumine.

We conclude that the use of combination of methoxyflurane and flunixin meglumine is contraindicated in dogs.

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Recognising bright futures     

Dr Anthony Down 《Australian veterinary journal》2005,83(1-2):10-10

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NSAIDs     

Dr Anthony Blikslager DVM  PhD  DACVS  Associate Professor  Dr Sam Jones DVM  PhD  DACVIM  Associate Professor 《Journal of Equine Veterinary Science》2005,25(3):98-102

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THE EFFECTS OF PATIENT POSITIONING AND SLICE SELECTION ON CANINE ACETABULAR ANGLE ASSESSMENT WITH COMPUTED TOMOGRAPHY     

Sandy I. Wang  DVM    Kyle G. Mathews  DVM  MS    Ian D. Robertson  BVSc    Marty Stebbins  DVM  PhD    Brian J. Trumpatori  BS 《Veterinary radiology & ultrasound》2005,46(1):39-43

Acetabular angles (AAs) and dorsal acetabular rim angles acquired by computed tomographic (CT) imaging have been used to assess patient response to juvenile pubic symphysiodesis surgery. The purpose of this study was to evaluate the effects of patient positioning and slice selection on these angles, and an attempt was made to devise a repeatable method of measuring these angles that would eliminate positioning effects. We found significant variation in AAs with small differences in pelvic tilt and slice selection. Dorsal acetabular rim angles were not affected. As a result of positioning differences from one CT study to the next, every attempt should be made to standardize pelvic tilt, or eliminate its effect on AAs by standardizing gantry angle in relation to an anatomic landmark that will not change over time. The floor of the sacral vertebral canal may be a reasonable landmark for this purpose and deserves further study.  相似文献   

Identification of a major gene (Mex-1) from Coffea canephora conferring resistance to Meloidogyne exigua in Coffea arabica     

S. Noir  F. Anthony  B. Bertrand  M.-C. Combes  P. Lashermes † 《Plant pathology》2003,52(1):97-103

Among the most damaging root-knot nematode species, Meloidogyne exigua is especially common in Latin America and constitutes a major agronomic constraint in all major coffee-growing ( Coffea arabica ) areas. Growing nematode-resistant coffee represents the most promising option for control of the pest. The present study aimed to determine the mode of inheritance of the M. exigua resistance transferred into C. arabica from a related species, Coffea canephora , and to identify associated molecular markers. Segregation data analysis of F ₂ progeny derived from a cross between the resistant introgression line T5296 and the susceptible accession Et6 showed that the resistance to M. exigua is controlled by a simply inherited major gene (designated the Mex -1 locus). The gall index distribution exhibited by the F ₂ individuals suggested incomplete dominant expression. Fourteen AFLP markers were found associated with the resistance to M. exigua and a localized genetic map of the chromosome segment carrying Mex -1 was constructed. Furthermore, the association of the identified AFLP markers with Mex -1 was confirmed by analysis of a set of genotypes involving 28 introgression Arabica lines either resistant or susceptible to M. exigua in field conditions. These results represent an important starting point to enhance backcross breeding programmes and to perform an early selection of resistant seedlings.  相似文献   

Feline arterial thromboembolism: an update.     

Stephanie A Smith  Anthony H Tobias 《Veterinary Clinics of North America: Small Animal Practice》2004,34(5):1245-1271

ATE remains a devastating complication of cardiac disease. Despite some improvements in our understanding of the underlying causes and clinical features of this disease, short-term management remains a challenge, and mortality is high. Long-term mortality is primarily attributable to the severe underlying cardiac disease. Many questions remain to be answered regarding the ideal management approach for feline ATE. The authors' preferred diagnostic and therapeutic approaches for these difficult patients are detailed in Box. 1.  相似文献