排序方式: 共有2条查询结果,搜索用时 0 毫秒
1
1.
2.
Nakkawee SAENGKLUB Vudhiporn LIMPRASUTR Suwanakiet SAWANGKOON Chollada BURANAKARL Robert L. HAMLIN Anusak KIJTAWORNRAT 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2016,78(2):177-186
Dronedarone is a class III antiarrhythmic that has been used for management of atrial fibrillation in humans,
but limited information was found in dogs. The objective of this study was to determine the acute effects of
escalating concentrations of dronedarone on electrocardiograms (ECG), hemodynamics and cardiac mechanics in
healthy dogs. A total of 7 beagle dogs were anesthetized with isoflurane and instrumented to obtain lead II
ECG, pressures at ascending aorta, right atrium, pulmonary artery and left ventricle, and left ventricular
pressure-volume relationship. Five dogs were given vehicle and followed by escalating doses of dronedarone
(0.5, 1.0 and 2.5 mg/kg, 15 min for each dose), and two dogs were used as a vehicle-treated control. All
parameters were measured at 15 min after the end of each dose. The results showed that all parameters in
vehicle-treated dogs were unaltered. Dronedarone at 2.5 mg/kg significantly lengthened PQ interval
(P<0.01), reduced cardiac output (P<0.01) and increased systemic
vascular resistance (P<0.01). Dronedarone produced negative inotropy assessed by
significantly lowered end-systolic pressure-volume relationship, preload recruitable stroke work,
contractility index and dP/dtmax. It also impaired diastolic function by significantly increased
end-diastolic pressure-volume relationship, tau and dP/dtmin. These results suggested that acute
effects of dronedarone produced negative dromotropy, inotropy and lusitropy in anesthetized dogs. Care should
be taken when given dronedarone to dogs, especially when the patients have impaired cardiac function. 相似文献
1