Male pseudohermaphroditism in a Labrador Retriever,and a review of mammalian sexual differentiation     

BGJ Wernham  RM Jerram 《New Zealand veterinary journal》2013,61(5):248-252

CASE HISTORY: An 8-month-old Labrador Retriever was referred with a history of ambiguous external genitalia.

CLINICAL FINDINGS AND TREATMENT: Clitoromegaly within apparent vulval folds, and an adjacent subcutaneous mass were noticed on external examination. An intra-abdominal testicle, with epididymis and suspected vas deferens ducts, was found during exploratory celiotomy. Incision over the subcutaneous mass revealed the accompanying testicle. Clitoridectomy was performed and an os clitoris removed. Normal juvenile testes were diagnosed on histology of the gonads. Chromosomal studies revealed a normal 78, XY male chromosomal constitution. Due to the combination of a male karyotype (78, XY), the presence of testicular tissue in the gonads, and the appearance of the external genitalia, a diagnosis of male pseudohermaphroditism (MPH) was made.

CLINICAL RELEVANCE: This case presents the first report of MPH in a Labrador Retriever, and highlights the diagnostic steps recommended when confronted with a dog with ambiguous external genitalia.  相似文献   

Cricopharyngeal dysphagia and phenobarbitone‐responsive sialoadenosis in a Miniature Poodle          下载免费PDF全文

SAM McCann  M le Chevoir  L Lacorcia  BGJ Wernham  CS Mansfield 《Australian veterinary journal》2017,95(7):232-236

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Dose reduction of meloxicam in dogs with osteoarthritis-associated pain and impaired mobility     

Wernham BG  Trumpatori B  Hash J  Lipsett J  Davidson G  Wackerow P  Thomson A  Lascelles BD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2011,25(6):1298-1305

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Male pseudohermaphroditism in a Labrador Retriever, and a review of mammalian sexual differentiation     

Wernham BG  Jerram RM 《New Zealand veterinary journal》2006,54(5):248-252

CASE HISTORY: An 8-month-old Labrador Retriever was referred with a history of ambiguous external genitalia. CLINICAL FINDINGS AND TREATMENT: Clitoromegaly within apparent vulval folds, and an adjacent subcutaneous mass were noticed on external examination. An intra-abdominal testicle, with epididymis and suspected vas deferens ducts, was found during exploratory celiotomy. Incision over the subcutaneous mass revealed the accompanying testicle. Clitoridectomy was performed and an os clitoris removed. Normal juvenile testes were diagnosed on histology of the gonads. Chromosomal studies revealed a normal 78, XY male chromosomal constitution. Due to the combination of a male karyotype (78, XY), the presence of testicular tissue in the gonads, and the appearance of the external genitalia, a diagnosis of male pseudohermaphroditism (MPH) was made. CLINICAL RELEVANCE: This case presents the first report of MPH in a Labrador Retriever, and highlights the diagnostic steps recommended when confronted with a dog with ambiguous external genitalia.  相似文献